Research Topics
Species | I M ReaSummaryAffiliation: Queen's University Belfast Country: UK Publications
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Detail Information
Publications
CD69, CD25, and HLA-DR activation antigen expression on CD3+ lymphocytes and relationship to serum TNF-alpha, IFN-gamma, and sIL-2R levels in agingI M Rea
Department of Geriatric Medicine, The Queen s University of Belfast, Northern Ireland, UK
Exp Gerontol 34:79-93. 1999....- Nature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)I Maeve Rea
Department of Geriatric Medicine, The Queen s University Belfast, Whitla Medical Building, Belfast, Northern Ireland, UK
Age (Dordr) 31:261-7. 2009..36/kg), skin-fold-thickness (OR?=?1.33/mm) and serum sodium (OR?=?1.37 mmol/l). In BELFAST participants over 80 years old, blood pressure ?140/90 mmHg is associated with BMI, in apparently similar ways to younger groups... - Malondialdehyde and measures of antioxidant activity in subjects from the Belfast Elderly Longitudinal Free-living Aging StudyI M Rea
Department of Geriatric Medicine, Whitla Medical Building, Queens University Belfast, Belfast BT9 7BL, United Kingdom
Ann N Y Acad Sci 1019:392-5. 2004..73). These results might overall represent a situation in which elderly survivors in the BELFAST study have evolved a sort of free radical/antioxidant equilibrium as a mechanism of successful aging... - Ageing in the 21st Century. Where to and how will we get there? Report on the 10th congress of the international association of biomedical gerontology, the geriatrician's viewI Maeve Rea
Department of Geriatric Medicine, The Queen's University of Belfast, Whitla Medical Bldg, 97Lisburn Road, Belfast BT9 7BL, UK
Exp Gerontol 39:283-4. 2004 - BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factorsI M Rea
Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
Immun Ageing 7:6. 2010..Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST)... - Total serum IL-12 and IL-12p40, but not IL-12p70, are increased in the serum of older subjects; relationship to CD3(+)and NK subsetsI M Rea
Department of Geriatric Medicine, The Queen s University of Belfast, Belfast, UK
Cytokine 12:156-9. 2000..07) subset. These findings may have important implications for understanding the functional activity of IL-12 and its p40 and p70 subunits in vivo and with respect to T-or NK-cell activation in aging... - Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST)I M Rea
Department of Geriatric Medicine, The Queen s University, Belfast BT7 1NN, UK
Mech Ageing Dev 122:1367-72. 2001..1; P=0.0006), the E3 unchanged and E2 frequency was increased (X(2)=4.0; P=0.047). These results suggest that longevity is negatively associated with the E4 allele and may be associated with carriage of E2... - Serum heat shock protein and anti-heat shock protein antibody levels in agingI M Rea
Department of Geriatric Medicine, The Queen s University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK
Exp Gerontol 36:341-52. 2001..Further studies are required to understand the basis for declining serum Hsp60 and Hsp70 levels in aging and to elucidate their origin and role in the maintenance of homeostasis and resistance to environmental challenges... - Community-living nonagenarians in northern ireland have lower plasma homocysteine but similar methylenetetrahydrofolate reductase thermolabile genotype prevalence compared to 70-89-year-old subjectsI M Rea
Cardiovascular Research Centre, The Queen s University of Belfast, Belfast, UK
Atherosclerosis 149:207-14. 2000.... - BELFAST centenarians: a case of optimised cardiovascular risk?E Bennati
Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast and Belfast City Hospital, UK
Curr Pharm Des 16:789-95. 2010..Methods: Thirty-five (27 female, 8 male) centenarians, participants of the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST), were community-living and of good cognition at enrollment... - A whole blood method for measurement of intracellular TNF-alpha, IFN-gamma and IL-2 expression in stimulated CD3+ lymphocytes: differences between young and elderly subjectsS E McNerlan
Department of Geriatric Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT7 9AB, UK
Exp Gerontol 37:227-34. 2002..In contrast, IL-2 secreting CD3+ cells were associated with TNF-alpha and IFN-gamma producing CD3+ cells in young but not elderly subjects providing further evidence for the remodelling of the cytokine network associated with old age... - Investigation of KIR diversity in immunosenescence and longevity within the Irish populationLynn D Maxwell
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, Northern Ireland, UK
Exp Gerontol 39:1223-32. 2004..In view of the lack of studies to date, investigating the role of the KIR gene system in healthy ageing, further analysis of KIR diversity is required to fully elucidate it's role in respect to age-related disease and longevity... - Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the IrishOwen A Ross
School of Biology and Biochemistry, Queens University of Belfast, Medical Biology Centre, and Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland, UK
Exp Gerontol 39:801-5. 2004.... - HLA haplotypes and TNF polymorphism do not associate with longevity in the IrishOwen A Ross
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, BT9 7TS, Northern Ireland, Belfast, UK
Mech Ageing Dev 124:563-7. 2003..However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide... - Study of age-association with cytokine gene polymorphisms in an aged Irish populationOwen A Ross
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, Belfast City Hospital, Belfast BT9 7TS, UK
Mech Ageing Dev 124:199-206. 2003..These findings would suggest that polymorphism of cytokine genes may not play as crucial a role in healthy ageing as previously believed... - Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish populationOwen A Ross
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Northern Ireland, Belfast, UK
Exp Gerontol 38:561-5. 2003....