Norman S Williams

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. ncbi The APPEAR technique: a new concept in ultralow sphincter-saving resection
    Norman S Williams
    Dis Colon Rectum 51:369-70; author reply 371. 2008
  2. ncbi Stoma reversal: limitations and pitfalls
    Norman S Williams
    Lancet Oncol 8:278-9. 2007
  3. ncbi External pelvic rectal suspension (the Express procedure) for full-thickness rectal prolapse: evolution of a new technique
    N S Williams
    Center for Academic Surgery, The Royal London Hospital, Fourth Floor Alexandra Wing, London E1 1BB, Whitechapel, United Kingdom
    Dis Colon Rectum 48:307-16. 2005
  4. ncbi EXternal Pelvic REctal SuSpension (Express procedure) for rectal intussusception, with and without rectocele repair
    N S Williams
    Centre for Academic Surgery, 4th Floor Alexandra Wing, The Royal London Hospital, Whitechapel, London E1 1BB, UK
    Br J Surg 92:598-604. 2005
  5. ncbi Anterior Perineal PlanE for Ultra-low Anterior Resection of the Rectum (the APPEAR technique): a prospective clinical trial of a new procedure
    Norman S Williams
    Centre for Academic Surgery, Institute for Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, United Kingdom
    Ann Surg 247:750-8. 2008
  6. ncbi Pelvic floor disorders and reconstruction--what next?
    Norman S Williams
    Centre for Academic Surgery, Barts and the London School of Medicine and Dentistry, Royal London Hospital, Whitechapel London, E1 1BB, United Kingdom
    Dis Colon Rectum 51:1309-11. 2008
  7. ncbi Rectal intussusception: a study of rectal biomechanics and visceroperception
    Lee S Dvorkin
    GI Physiology Unit, Center for Academic Surgery, Royal London Hospital, Whitechapel, London, United Kingdom
    Am J Gastroenterol 100:1578-85. 2005
  8. ncbi Rectal augmentation: short- and mid-term evaluation of a novel procedure for severe fecal urgency with associated incontinence
    Jamie Murphy
    Centre for Academic Surgery, Institute for Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London
    Ann Surg 247:421-7. 2008
  9. ncbi Does anastomotic technique influence anorectal function after sphincter-saving rectal cancer resection? A systematic review of evidence from randomized trials
    Jamie Murphy
    Centre for Academic Surgery, Bart's and The London, The Royal London Hospital, Whitechapel, London, UK
    J Am Coll Surg 204:673-80. 2007
  10. ncbi Efficacy of sacral nerve stimulation for the treatment of fecal incontinence
    Derek J Boyle
    Royal London Hospital, Academic Unit of Surgery, Centre for Digestive Diseases, 3rd Floor Alexandra Wing, Barts and The London NHS Trust, Whitechapel, London E1 1BB, United Kingdom
    Dis Colon Rectum 54:1271-8. 2011

Collaborators

Detail Information

Publications53

  1. ncbi The APPEAR technique: a new concept in ultralow sphincter-saving resection
    Norman S Williams
    Dis Colon Rectum 51:369-70; author reply 371. 2008
  2. ncbi Stoma reversal: limitations and pitfalls
    Norman S Williams
    Lancet Oncol 8:278-9. 2007
  3. ncbi External pelvic rectal suspension (the Express procedure) for full-thickness rectal prolapse: evolution of a new technique
    N S Williams
    Center for Academic Surgery, The Royal London Hospital, Fourth Floor Alexandra Wing, London E1 1BB, Whitechapel, United Kingdom
    Dis Colon Rectum 48:307-16. 2005
    ..The Délorme's operation for rectal prolapse is a safe procedure but has a high recurrence rate. We aimed to develop an operation akin to it, but designed to reduce this deficit...
  4. ncbi EXternal Pelvic REctal SuSpension (Express procedure) for rectal intussusception, with and without rectocele repair
    N S Williams
    Centre for Academic Surgery, 4th Floor Alexandra Wing, The Royal London Hospital, Whitechapel, London E1 1BB, UK
    Br J Surg 92:598-604. 2005
    ..The results of conventional treatment for rectal intussusception and rectocele are unpredictable. The aim was to develop a less invasive surgical approach and to evaluate outcome in selected patients...
  5. ncbi Anterior Perineal PlanE for Ultra-low Anterior Resection of the Rectum (the APPEAR technique): a prospective clinical trial of a new procedure
    Norman S Williams
    Centre for Academic Surgery, Institute for Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, United Kingdom
    Ann Surg 247:750-8. 2008
    ..This clinical trial (clinicaltrials.gov: NCT00534131) evaluated the short-term clinical and physiological results of this procedure...
  6. ncbi Pelvic floor disorders and reconstruction--what next?
    Norman S Williams
    Centre for Academic Surgery, Barts and the London School of Medicine and Dentistry, Royal London Hospital, Whitechapel London, E1 1BB, United Kingdom
    Dis Colon Rectum 51:1309-11. 2008
  7. ncbi Rectal intussusception: a study of rectal biomechanics and visceroperception
    Lee S Dvorkin
    GI Physiology Unit, Center for Academic Surgery, Royal London Hospital, Whitechapel, London, United Kingdom
    Am J Gastroenterol 100:1578-85. 2005
    ..In patients with RI and SRUS, rectal wall inflammation and fibrosis, perhaps arising secondary to the intussusception, may explain the physiological changes observed...
  8. ncbi Rectal augmentation: short- and mid-term evaluation of a novel procedure for severe fecal urgency with associated incontinence
    Jamie Murphy
    Centre for Academic Surgery, Institute for Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London
    Ann Surg 247:421-7. 2008
    ..This study evaluated the short- and medium-term clinical and physiologic results...
  9. ncbi Does anastomotic technique influence anorectal function after sphincter-saving rectal cancer resection? A systematic review of evidence from randomized trials
    Jamie Murphy
    Centre for Academic Surgery, Bart's and The London, The Royal London Hospital, Whitechapel, London, UK
    J Am Coll Surg 204:673-80. 2007
  10. ncbi Efficacy of sacral nerve stimulation for the treatment of fecal incontinence
    Derek J Boyle
    Royal London Hospital, Academic Unit of Surgery, Centre for Digestive Diseases, 3rd Floor Alexandra Wing, Barts and The London NHS Trust, Whitechapel, London E1 1BB, United Kingdom
    Dis Colon Rectum 54:1271-8. 2011
    ..However, "success" has been arbitrarily set at a 50% reduction in symptoms, and data are rarely reported with "intention to treat."..
  11. ncbi A novel technique to identify patients with megarectum
    Marc A Gladman
    Gastrointestinal Physiology Unit, Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, Whitechapel, London, United Kingdom
    Dis Colon Rectum 50:621-9. 2007
    ....
  12. ncbi Rectal intussusception: characterization of symptomatology
    Lee S Dvorkin
    Academic Department of Surgery (GI Physiology Unit, Royal London Hospital, Whitechapel, London, United Kingdom
    Dis Colon Rectum 48:824-31. 2005
    ....
  13. ncbi Efficacy of sacral nerve stimulation for fecal incontinence in patients with anal sphincter defects
    Derek J Boyle
    Centre for Academic Surgery, Gastrointestinal Physiology Unit, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Dis Colon Rectum 52:1234-9. 2009
    ..This rationale has been challenged, but it remains unknown if its efficacy is related to the extent of the sphincter injury...
  14. ncbi Multimedia article: external pelvic rectal suspension (the express procedure) for internal rectal prolapse, with or without concomitant rectocele repair: a video demonstration
    Julia E Dench
    Centre for Academic Surgery, GI Physiology Unit, The Royal London Hospital, Whitechapel, London, United Kingdom
    Dis Colon Rectum 49:1922-6. 2006
    ..CONCLUSIONS: This procedure promises to be an effective technique for managing patients with refractory evacuatory dysfunction secondary to internal rectal prolapse, with or without rectocele...
  15. ncbi Rectal hyposensitivity: a disorder of the rectal wall or the afferent pathway? An assessment using the barostat
    Marc A Gladman
    Centre for Academic Surgery (Gastrointestinal Physiology Unit, Barts and The London, Queen Mary's School of Medicine and Dentistry, Whitechapel, London E1 1BB, United Kingdom
    Am J Gastroenterol 100:106-14. 2005
    ..However, a second subgroup exists with normal rectal wall properties, suggestive of a true impairment of the afferent pathway. The barostat has an important role in the identification of these subgroups of patients...
  16. ncbi Full-thickness pouch prolapse after restorative proctocolectomy: a potential future problem treated by the new technique of external pelvic neorectal suspension (the Express procedure)
    Norman S Williams
    Centre for Academic Surgery, The Royal London Hospital, Whitechapel, London, United Kingdom
    Dis Colon Rectum 47:1415-9. 2004
    ....
  17. ncbi Rectal hypersensitivity worsens stool frequency, urgency, and lifestyle in patients with urge fecal incontinence
    Christopher L H Chan
    Centre for Academic Surgery, Barts and The London, Queen Mary's School of Medicine and Dentistry, Whitechapel, London, United Kingdom
    Dis Colon Rectum 48:134-40. 2005
    ....
  18. ncbi Anal sphincter morphology in patients with full-thickness rectal prolapse
    Lee S Dvorkin
    Academic Center for Surgery (GI Physiology Unit, Roval London Hospital, London, United Kingdom
    Dis Colon Rectum 47:198-203. 2004
    ..Patients found to have this feature on endoanal ultrasound should undergo clinical examination and defecography to look for rectal wall abnormalities...
  19. ncbi Anterior Perineal PlanE for Ultralow Anterior Resection of the Rectum (the APPEAR Technique): a video demonstration
    Khalid A El-Gendy
    Centre for Academic Surgery, Institute for Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, London, England, UK
    Ann Surg Oncol 17:1357-8. 2010
    ..It ensures that the distal rectum is excised and the anastomosis is constructed under direct vision while simultaneously preserving the anal sphincter and its somatic nerve supply in their entirety...
  20. ncbi Systematic review of surgical options for idiopathic megarectum and megacolon
    Marc A Gladman
    Centre for Academic Surgery (Gastrointestinal Physiology Unit, Barts, London, UK
    Ann Surg 241:562-74. 2005
    ..Appropriately designed studies are required to make valid comparisons of the different procedures available...
  21. ncbi Percutaneous tibial nerve stimulation for the treatment of urge fecal incontinence
    Derek J Boyle
    University of London, London, UK
    Dis Colon Rectum 53:432-7. 2010
    ..This study aimed to assess the efficacy of percutaneous tibial nerve stimulation in the treatment of urge fecal incontinence...
  22. ncbi Risk factors in acquired faecal incontinence
    Peter J Lunniss
    Centre for Academic Surgery, Gastrointestinal Physiology Unit, Queen Mary's School of Medicine and Dentistry, Royal London Hospital, Whitechapel, London E1 1BB, UK
    J R Soc Med 97:111-6. 2004
    ..These findings add to evidence that occult damage to the continence mechanism, especially through vaginal delivery and anal surgery, can result in subsequent faecal incontinence, sometimes after an interval of many years...
  23. ncbi Prospective randomized double-blind study of temporary sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity
    Charles H Knowles
    Academic Surgical Unit, Centre for Digestive Disease, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Ann Surg 255:643-9. 2012
    ....
  24. ncbi Rectal hyposensitivity: prevalence and clinical impact in patients with intractable constipation and fecal incontinence
    Marc A Gladman
    Academic Department of Surgery and Gastrointestinal Physiology Unit, Barts and The London, Queen Mary's School of Medicine and Dentistry, United Kingdom
    Dis Colon Rectum 46:238-46. 2003
    ..Although the clinical relevance of this physiologic abnormality is unknown, its presence may have implications regarding the management of hindgut dysfunction and particularly the selection of patients for surgery...
  25. ncbi Accurate localization of a fall in pH within the ileocecal region: validation using a dual-scintigraphic technique
    Natalia Zarate
    Queen Mary University London, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 299:G1276-86. 2010
    ..This phenomenon can be used as a biomarker of transition between the small and large bowel and validates assessment of regional GI motility using capsule technology that incorporates pH measurement...
  26. ncbi Rectal hyposensitivity: pathophysiological mechanisms
    M A Gladman
    Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Whitechapel, London, UK
    Neurogastroenterol Motil 21:508-16, e4-5. 2009
    ..Identification of these subgroups of patients with RH may have implications regarding their management...
  27. ncbi Rectal augmentation and stimulated gracilis anal neosphincter: a new approach in the management of fecal urgency and incontinence
    N S Williams
    Academic Department of Surgery, St. Bartholomew's and the Royal London School of Medicine and Dentistry, The Royal London Hospital, United Kingdom
    Dis Colon Rectum 44:192-8. 2001
    ..CONCLUSIONS: Combined rectal augmentation with stimulated gracilis anal neosphincter may be of benefit to some patients with distressing urgency and fecal incontinence not previously helped by current techniques...
  28. ncbi Importance of extrasphincteric mechanisms in the pathophysiology of faecal incontinence in adults with a history of anorectal anomaly
    E P Athanasakos
    Centre for Academic Surgery, Barts and the London School of Medicine and Dentistry, The Royal London Hospital, Whitechapel, London, UK
    Br J Surg 95:1394-400. 2008
    ..Apart from the anal sphincters, continence is dependent on multiple anatomical and physiological factors. The aim of this study was to evaluate adults with a history of ARA to determine the role of such factors in functional outcome...
  29. ncbi Parastomal hernia prevention using a novel collagen implant: a randomised controlled phase 1 study
    T M Hammond
    Centre for Academic Surgery, Institute of Cellular and Molecular Science, The Royal London Hospital, Barts and The London NHS Trust, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Hernia 12:475-81. 2008
    ..The study aim was to assess the safety, feasibility and potential efficacy of using a prophylactic collagen implant...
  30. ncbi Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency
    C L H Chan
    Peripheral Neuropathy Unit, Imperial College London, Hammersmith Hospital, London, UK
    Lancet 361:385-91. 2003
    ..We aimed to determine whether expression of the heat and capsaicin receptor vanilloid receptor 1 (TRPV1 or VR1) was changed in rectal sensory fibres, and to correlate nerve fibre density with sensory abnormalities...
  31. ncbi Human in vivo cellular response to a cross-linked acellular collagen implant
    T M Hammond
    Centre for Academic Surgery, Institute of Cellular and Molecular Science, The Royal London Hospital, Barts and The London NHS Trust, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Br J Surg 95:438-46. 2008
    ..The aim was to evaluate the human host response to an acellular porcine-derived cross-linked collagen implant...
  32. ncbi Normalization of substance P levels in rectal mucosa of patients with faecal incontinence treated successfully by sacral nerve stimulation
    M L Gooneratne
    Gastrointestinal Physiology Unit, Centre for Academic Surgery, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Br J Surg 95:477-83. 2008
    ..Sacral nerve stimulation (SNS) may improve faecal incontinence by modulating rectal sensation. This study measured changes in the peripheral expression of various neural epitopes in response to SNS...
  33. ncbi Clinical and physiological findings, and possible aetiological factors of rectal hyposensitivity
    M A Gladman
    Academic Department of Surgery and Gastrointestinal Physiology Unit, St Bartholomew s and the London School of Medicine and Dentistry, London, UK
    Br J Surg 90:860-6. 2003
    ..Rectal hyposensitivity (RH) relates to insensitivity of the rectum on anorectal physiological investigation and appears common in functional bowel disorders. The clinical significance of this physiological abnormality is unclear...
  34. ncbi Use of a continent colonic conduit for treatment of refractory evacuatory disorder following construction of an electrically stimulated gracilis neoanal sphincter
    J R Saunders
    Academic Department of Surgery, Barts and The London, Queen Mary School of Medicine and Dentistry, London, UK
    Br J Surg 90:1416-21. 2003
    ....
  35. ncbi Third-party prospective evaluation of patient outcomes after dynamic graciloplasty
    T Tillin
    International Centre for Circulatory Health, Imperial College at St Mary s, London, UK
    Br J Surg 93:1402-10. 2006
    ..Dynamic graciloplasty (DGP) is a complex procedure designed to improve bowel function in patients with end-stage faecal incontinence. Outcomes of DGP were examined in comparison with stoma formation or continued medical management...
  36. ncbi The Colorectal Development Unit: impact on functional outcome for the electrically stimulated gracilis neoanal sphincter
    J R Saunders
    Centre for Academic Surgery, Barts and The London, Queen Mary School of Medicine and Dentistry, London, UK
    Colorectal Dis 8:46-55. 2006
    ..The aim of this study was to investigate the impact of the CDU on functional outcome and complications...
  37. ncbi Rectal intussusception in symptomatic patients is different from that in asymptomatic volunteers
    L S Dvorkin
    Gastrointestinal Physiology Unit, Centre for Academic Surgery, Royal London Hospital, UK
    Br J Surg 92:866-72. 2005
    ..However, caution is required when selecting patients for intervention based solely on radiological findings...
  38. ncbi Medium-term results of vertical reduction rectoplasty and sigmoid colectomy for idiopathic megarectum
    M A Gladman
    Centre for Academic Surgery (Gastrointestinal Physiology Unit, St Bartholomew's and the Royal London Hospital, Queen Mary's School of Medicine and Dentistry, Whitechapel, London, UK
    Br J Surg 92:624-30. 2005
    ..The procedure was associated with a low morbidity, and no mortality and should be considered in the surgical management of IMR...
  39. ncbi Smooth muscle inclusion bodies in slow transit constipation
    C H Knowles
    Academic Department of Surgery, St Bartholomew's and the Royal London School of Medicine and Dentistry, Whitechapel, London E1 1BB, UK
    J Pathol 193:390-7. 2001
    ..This study demonstrates that inclusion body myopathy is identifiable in patients with STC and that it may arise secondary to denervation...
  40. ncbi Platelet-leucocyte aggregates form in the mesenteric vasculature in patients with ulcerative colitis
    Peter M Irving
    Centre for Gastroenterology, Queen Mary School of Medicine, Barts and The London NHS Trust, London, UK
    Eur J Gastroenterol Hepatol 20:283-9. 2008
    ..The aims of this study were to test the hypotheses that platelet-leucocyte aggregation, platelet activation and neutrophil activation occur in the mesenteric vessels of patients with ulcerative colitis (UC)...
  41. ncbi Scintigraphic assessment of colonic transit in women with slow-transit constipation arising de novo and following pelvic surgery or childbirth
    S M Scott
    Academic Department of Surgery Gastrointestinal Physiology Unit, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Br J Surg 88:405-11. 2001
    ..Colonic transit has not been compared between patients with slow-transit constipation (STC) arising de novo (idiopathic) and those whose symptoms followed pelvic surgery or childbirth (acquired)...
  42. ncbi Open-magnet MR defaecography compared with evacuation proctography in the diagnosis and management of patients with rectal intussusception
    L S Dvorkin
    Academic Department of Surgery (GI Physiology Unit, Royal London Hospital Interventional Magnetic Resonance Unit, St Mary's Hospital, London, UK
    Colorectal Dis 6:45-53. 2004
    ....
  43. ncbi Automated quantitative analysis of nocturnal jejunal motor activity identifies abnormalities in individuals and subgroups of patients with slow transit constipation
    S M Scott
    Gastrointestinal Physiology Unit, Academic Department of Surgery, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
    Am J Gastroenterol 98:1123-34. 2003
    ..In contrast to previous reports, evidence of generalized enteric dysmotility may be present irrespective of the mode of onset...
  44. ncbi Rectal sensorimotor dysfunction in patients with urge faecal incontinence: evidence from prolonged manometric studies
    C L H Chan
    Centre for Academic Surgery, Barts and The London, Queen Mary's School of Medicine and Dentistry, London, UK
    Gut 54:1263-72. 2005
    ..Comprehensive assessment of rectosigmoid sensorimotor function, in addition to evaluation of anal function, should be considered in the investigation of patients with urge faecal incontinence...
  45. ncbi The combination of electrically stimulated gracilis neoanal sphincter and continent colonic conduit: a step forward for total anorectal reconstruction?
    Jason R Saunders
    Academic Department of Surgery, Barts and The Royal London Hospital, Queen Mary s School of Medicine and Dentistry, London, United Kingdom
    Dis Colon Rectum 47:354-63; discussion 363-6. 2004
    ....
  46. ncbi Smooth muscle cholinergic denervation hypersensitivity in diverticular disease
    Mark Golder
    Academic Department of Surgery, Barts and the London School of Medicine and Dentistry, Whitechapel, London, UK
    Lancet 361:1945-51. 2003
    ..We aimed to investigate the role of smooth muscle and neural cholinergic activity in the pathogenesis of this disease...
  47. ncbi Rectal heat thresholds: a novel test of the sensory afferent pathway
    Christopher L H Chan
    Academic Department of Surgery, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Dis Colon Rectum 46:590-5. 2003
    ..Heat stimulation is a simple technique that has a high degree of repeatability and may be an objective assessment of polymodal nociceptor function in the rectum...
  48. ncbi Decreased tyrosine kinase C expression may reflect developmental abnormalities in Hirschsprung's disease and idiopathic slow-transit constipation
    P Facer
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Br J Surg 88:545-52. 2001
    ..Trk C activation by NT-3 or drugs may provide novel treatments. Presented in abstract form to the Pacific Association of Pediatric Surgeons, Las Vegas, Nevada, USA, May 2000..
  49. ncbi Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel
    Steven J Arnold
    Imperial College of Sciences, Technology and Medicine, Hammersmith Hospital, London, UK
    Neuroreport 14:191-5. 2003
    ..Our findings may explain the diarrhoea and colicky abdominal pain produced by inflammatory bowel disease, and by IK1-blocking pyridine drugs prescribed for neuromuscular disorders...
  50. ncbi ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease
    Y Yiangou
    Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Neurogastroenterol Motil 13:365-9. 2001
    ..01). In humans, unlike rodents, P2X(3) is thus not restricted to sensory neurones. Increased P2X(3) in inflamed intestine suggests a potential role in dysmotility and pain, for which it represents a new therapeutic target...
  51. ncbi Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study
    Richard Gray
    Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK
    Lancet 370:2020-9. 2007
    ..The aim of the QUASAR trial was to determine the size and duration of any survival benefit from adjuvant chemotherapy for patients with colorectal cancer at low risk of recurrence, for whom the indication for such treatment is unclear...
  52. ncbi Why are so many patients with rectal cancer still treated with abdominoperineal resection in America?
    Jamie Murphy
    Dis Colon Rectum 51:1435. 2008
  53. ncbi The patient with diverticular disease
    Mark Golder
    University Hospital Lewisham, London
    Practitioner 249:663-4, 666, 669 passim. 2005