Research Topics
| D W WarehamSummaryAffiliation: Queen Mary Country: UK Publications
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Detail Information
Publications
Antimicrobial resistance in community and nosocomial Escherichia coli urinary tract isolates, London 2005-2006David C Bean
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
Ann Clin Microbiol Antimicrob 7:13. 2008..We therefore set out to determine levels of resistance to 8 commonly used antimicrobial agents amongst all urinary isolates obtained over a 12 month period...- A novel variant, NDM-5, of the New Delhi metallo-?-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United KingdomMichael Hornsey
Antimicrobial Research Group, Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London School ofMedicine and Dentistry, Queen Mary University London, London, United Kingdom
Antimicrob Agents Chemother 55:5952-4. 2011..coli TOP10 transformants to expanded-spectrum cephalosporins and carbapenems when expressed under its native promoter... - Bloodstream infection due to Acinetobacter spp: epidemiology, risk factors and impact of multi-drug resistanceD W Wareham
Division of Infection, Barts and The London NHS Trust, London, UK
Eur J Clin Microbiol Infect Dis 27:607-12. 2008..A prospective study is required to identify both the most effective intervention and those most likely to benefit from treatment... - Herpes zosterDavid W Wareham
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine and Dentistry
BMJ 334:1211-5. 2007 - A genotypic and phenotypic comparison of type III secretion profiles of Pseudomonas aeruginosa cystic fibrosis and bacteremia isolatesDavid W Wareham
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London E1 2AT, UK
Int J Med Microbiol 297:227-34. 2007..Detection of TTSS toxins in clinical material may be useful in targeting antimicrobial therapy or identifying individuals infected with aggressive strains of P. aeruginosa... - Modifications to CHROMagar Acinetobacter for improved selective growth of multi-drug resistant Acinetobacter baumanniiD W Wareham
Centre for Immunology and Infectious Disease, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
J Clin Pathol 64:164-7. 2011..The medium was effective in suppressing the growth of other Gram-positive and Gram-negative species while the addition of KPC supplement ensured growth of only carbapenem resistant A baumannii... - In-vitro activity of polymyxin B in combination with imipenem, rifampicin and azithromycin versus multidrug resistant strains of Acinetobacter baumannii producing OXA-23 carbapenemasesDavid W Wareham
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
Ann Clin Microbiol Antimicrob 5:10. 2006..baumannii causing infection in the UK, we performed synergy testing against representative isolates using two rapid Etest methods... - In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumanniiD W Wareham
Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
J Antimicrob Chemother 66:1047-51. 2011..As teicoplanin has less nephrotoxic potential than vancomycin, we assessed whether a colistin/teicoplanin combination would have similar antimicrobial activities in vitro... - The Pseudomonas aeruginosa PA14 type III secretion system is expressed but not essential to virulence in the Caenorhabditis elegans-P. aeruginosa pathogenicity modelDavid W Wareham
MRC Molecular Pathogenesis Research Group, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London Queen Mary s School of Medicine and Dentistry, University of London, London E1 2AA, UK
FEMS Microbiol Lett 242:209-16. 2005..A fuller understanding of the mechanism of resistance to type III attack in C. elegans may lead to the identification and development of novel therapeutic targets affording protection to TTSS products in man... - Paradoxical effect of 1-(1-naphthylmethyl)-piperazine on resistance to tetracyclines in multidrug-resistant Acinetobacter baumanniiD C Bean
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
J Antimicrob Chemother 63:349-52. 2009..We investigated the interaction of NMP with tigecycline and three other tetracyclines on clinical isolates of A. baumannii... - Potent synergy and sustained bactericidal activity of a vancomycin-colistin combination versus multidrug-resistant strains of Acinetobacter baumanniiN C Gordon
Division of Infection, Barts and The London NHS Trust, London E1 2AT, United Kingdom
Antimicrob Agents Chemother 54:5316-22. 2010..5 ?g/ml colistin. This raises the possibility of the clinical use of this combination for infections due to MDRAB, with the potential for doses lower than those currently used... - Novel variants of the Smqnr family of quinolone resistance genes in clinical isolates of Stenotrophomonas maltophiliaN C Gordon
Division of Infection, Barts and The London NHS Trust, Newark Street, Whitechapel, London E1 2ES, UK
J Antimicrob Chemother 65:483-9. 2010..This study describes further novel variants present in clinical isolates of S. maltophilia and investigates their effect on resistance to a number of quinolones in an Escherichia coli host... - In vivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infectionM Hornsey
Antimicrobial Research Group, Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Antimicrob Agents Chemother 55:3534-7. 2011..baumannii both in vitro and in a simple animal model of infection. They should be considered further as potential treatments for difficult-to-treat A. baumannii infections... - Failure of the MicroScan WalkAway system to detect heteroresistance to carbapenems in a patient with Enterobacter aerogenes bacteremiaN C Gordon
Division of Infection, Barts and The London NHS Trust, London, United Kingdom
J Clin Microbiol 47:3024-5. 2009..Carbapenem resistance has become an increasing concern in recent years, and robust surveillance is required to prevent dissemination of resistant strains. Reliance on automated systems may delay the detection of emerging resistance... - A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecyclineN C Gordon
Division of Infection, Barts and The London NHS Trust, London, UK
J Antimicrob Chemother 63:775-80. 2009.... - Evaluation of CHROMagar Acinetobacter for detection of enteric carriage of multidrug-resistant Acinetobacter baumannii in samples from critically ill patientsN C Gordon
Division of Infection, Barts and The London NHS Trust, London, United Kingdom
J Clin Microbiol 47:2249-51. 2009..Results were compared with a molecular assay resulting in sensitivity and specificity of culture compared to PCR of 91.7% and 89.6%, respectively... - AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumanniiMichael Hornsey
Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK
J Antimicrob Chemother 65:1589-93. 2010..baumannii clones. The role of AdeABC in the emergence of tigecycline resistance during therapy was also investigated for two representatives of the prevalent UK lineage, OXA-23 clone 1... - Treatment of prosthetic valve infective endocarditis due to multi-resistant Gram-positive bacteria with linezolidD W Wareham
Department of Medical Microbiology, Barts and The London NHS Trust, London E1 1BB, UK
J Infect 52:300-4. 2006..It challenges the conventional wisdom that bactericidal synergy is required for the effective treatment of most cases of IE due to Gram-positive organisms... - Listeriosis due to infection with a catalase-negative strain of Listeria monocytogenesJ A Cepeda
Department of Medical Microbiology, Barts and The London NHS Trust, London, United Kingdom
J Clin Microbiol 44:1917-8. 2006..The sporadic occurrence of pathogenic catalase-negative strains highlights the need for a reconsideration of diagnostic criteria and questions the role of catalase in the pathogenesis of listeria infection... - Polymicrobial necrotizing fasciitis involving enterobacteria producing CTX-M-15 extended-spectrum ?-lactamasesS Soleimanian
Division of Infection, Barts and The London NHS Trust, London, UK
J Med Microbiol 60:135-7. 2011.... - Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistanceNicola C Gordon
Division of Infection, Barts and The London NHS Trust, London, UK
Int J Antimicrob Agents 35:219-26. 2010..In this article, we provide an overview of current knowledge, focusing on mechanisms of pathogenesis, the molecular basis of resistance and options for treatment in the absence of novel therapeutic agents... - Anaerobic sepsis due to multidrug-resistant Bacteroides fragilis: microbiological cure and clinical response with linezolid therapyD W Wareham
Department of Microbiology, Barts and The London NHS Trust, London, United Kingdom
Clin Infect Dis 40:e67-8. 2005..Microbiological cure and clinical improvement was achieved with linezolid therapy, an agent that may be useful for the treatment of multidrug-resistant anaerobic infections... - Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophiliaNicola C Gordon
Division of Infection, Barts and The London NHS Trust, London, UK
Int J Antimicrob Agents 36:129-31. 2010..maltophilia. Although the mechanism of action is not yet clear, further studies to evaluate its clinical potential and role in combination with other antimicrobial agents are warranted... - The dangers of dog bitesDavid W Wareham
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
J Clin Pathol 60:328-9. 2007..The epidemiology and management of Capnocytophaga infections is discussed, as well as the role of prophylactic antibiotics in preventing these infections after dog bites... - Low concentrations of commercial alcohol hand rubs facilitate growth of and secretion of extracellular proteins by multidrug-resistant strains of Acinetobacter baumanniiJustin Edwards
Department of Medical Microbiology, Division of Infection, Barts and The London NHS Trust, Whitechapel, London E1 1BB, UK
J Med Microbiol 56:1595-9. 2007..One of these was identified as OmpA, which is recognized as having emulsifying activity, which could potentially confer enhanced pathogenicity to A. baumannii... - Chloramphenicol in the 21st centuryDavid W Wareham
London and Newham NHS Trusts, Department of Medical Microbiology, Royal London Hospital, London E1 1BB
Hosp Med 63:157-61. 2002..This article will review the activity, pharmacology, toxicology, uses and potential uses of chloramphenicol in an era of increasing antimicrobial resistance...