Research Topics
| R N PriceSummaryCountry: UK Publications
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Publications
Plasmodium vivax trophozoites insensitive to chloroquineWesley W Sharrock
International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
Malar J 7:94. 2008..vivax clinical isolates suggest that only ring stages (early trophozoites) are sensitive to chloroquine. In this study, the stage specific action of chloroquine was investigated in synchronous cryopreserved isolates of P. vivax...- World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malariaChristopher V Plowe
Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, Maryland 21201, USA
Malar J 6:121. 2007.... - The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malariaSue J Lee
Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
Malar J 7:149. 2008..Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other... - Comparison of three molecular methods for the detection and speciation of Plasmodium vivax and Plasmodium falciparumPrapaporn Boonma
Department of Parasitology, Faculty of Public Health, Mahidol University, Bangkok, Thailand
Malar J 6:124. 2007..PCR assays offer an alternative to microscopy which has been shown to have superior sensitivity and specificity. Unfortunately few comparative studies have been done on the various molecular based speciation methods... - A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malariaStephane Picot
Malaria Research Unit, EA 4170, University Lyon 1, Faculty of Medicine, Lyon, France
Malar J 8:89. 2009..The purpose of this systematic review was to determine the risk of treatment failure associated with specific polymorphisms in the parasite genome or gene copy number... - World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugsRic N Price
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
Malar J 6:119. 2007..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed... - Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malariaRic N Price
Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
Clin Infect Dis 42:1570-7. 2006..Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)... - Drug resistant falciparum malaria: clinical consequences and strategies for preventionR N Price
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
Drug Resist Updat 4:187-96. 2001..These short term measures will need to be accompanied by a longer term strategy to encourage antimalarial drug research and development... - Factors contributing to anemia after uncomplicated falciparum malariaR N Price
Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand
Am J Trop Med Hyg 65:614-22. 2001..Children aged < 5 years of age were more likely than older children or adults to become anemic. Coinfection with P. vivax attenuates the anemia of falciparum malaria, presumably by modifying the severity of the infection... - Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malariaR N Price
Information Health Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, NT 0811, Australia
Antimicrob Agents Chemother 51:4090-7. 2007..Lower plasma piperaquine concentrations and higher failure rates in children suggest that dose revision may be warranted in this age group... - Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparisonA Ratcliff
International Health Programme, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
Lancet 369:757-65. 2007..Our aim was to compare the safety and efficacy of dihydroartemisinin-piperaquine with that of artemether-lumefantrine in patients with uncomplicated malaria caused by multidrug-resistant P falciparum and P vivax... - Artesunate/mefloquine treatment of multi-drug resistant falciparum malariaR N Price
Shoklo Malaria Research Unit, Tak Province, Thailand
Trans R Soc Trop Med Hyg 91:574-7. 1997..This regimen is safe, well tolerated, and highly effective in the treatment of multi-drug resistant falciparum malaria... - Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malariaR N Price
Shoklo Malaria Research Unit, Tak Province, Thailand
Trans R Soc Trop Med Hyg 89:523-7. 1995..6-5.4]). Mefloquine should no longer be used alone for the treatment of multidrug resistant falciparum malaria in this area. Three-day combination regimens with artesunate or artemether are well tolerated and more effective... - In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivaxR N Price
Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Antimicrob Agents Chemother 54:5146-50. 2010..vivax and P. falciparum highlights the suitability of the drug as a novel partner for artemisinin-based combination therapy in regions where the two species are coendemic... - Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivaxR Suwanarusk
International Health Division, Menzies School of Health Research, Darwin, Australia
J Infect Dis 198:1558-64. 2008..Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia... - A case-control auditory evaluation of patients treated with artemisinin derivatives for multidrug-resistant Plasmodium falciparum malariaM van Vugt
Shoklo Malaria Research Unit, Mae Sot, Tak Province, Thailand
Am J Trop Med Hyg 62:65-9. 2000..This study failed to detect any evidence of significant neurotoxicity in patients treated previously with oral artemether or artesunate for acute malaria... - Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, IndonesiaA Ratcliff
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
Trans R Soc Trop Med Hyg 101:351-9. 2007..falciparum and P. vivax exists both to first- and second-line therapies. Preliminary data indicate that amodiaquine retains superior efficacy compared with CQ for CQ-resistant P. vivax... - Determinants of in vitro drug susceptibility testing of Plasmodium vivaxB Russell
International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
Antimicrob Agents Chemother 52:1040-5. 2008..vivax and suggest that susceptibility to chloroquine may be associated with variable growth rates. These findings have important implications for the phenotypic and downstream genetic characterization of P. vivax... - Artemisinin drugs: novel antimalarial agentsR N Price
Centre for Tropical Diseases, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK
Expert Opin Investig Drugs 9:1815-27. 2000..Artemisinin, artesunate and artemether are well-tolerated in both adults and children, with no evidence to date of serious clinical toxicity... - Artemisinin combination therapy for vivax malariaNicholas M Douglas
Menzies School of Health Research, Darwin, NT, Australia
Lancet Infect Dis 10:405-16. 2010..Analyses of the cost-effectiveness of ACTs for both Plasmodium species are needed to assess the role of these drugs in the control and elimination of vivax malaria... - The effect of varying analytical methods on estimates of anti-malarial clinical efficacyWendy J Verret
Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
Malar J 8:77. 2009..The aim of this study was to quantify the magnitude of the differences between efficacy estimates derived from these approaches and identify the factors underlying these differences... - Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphismsRossarin Suwanarusk
International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
PLoS ONE 2:e1089. 2007..vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined... - Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deploymentVerena Ilona Carrara
Shoklo Malaria Research Unit, Tak, Thailand
PLoS ONE 4:e4551. 2009.... - Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malariaTonia Woodberry
International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
Malar J 8:122. 2009..It is not known whether natural exposure to Plasmodium falciparum stimulates HGXPRT T cell reactivity in humans... - Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responsesTonia Woodberry
International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
J Infect Dis 198:134-42. 2008..In cross-sectional and longitudinal studies, we measured MSP5 antibody responses in Papuans with acute Plasmodium falciparum malaria, Plasmodium vivax malaria, and mixed P. falciparum and P. vivax malaria and in those with past exposure... - New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistanceRic N Price
International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
Curr Opin Infect Dis 22:430-5. 2009..vivax infection. We review the evidence for severe disease and the spread of drug-resistant P. vivax and speculate how these maybe related... - Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua, IndonesiaTsin W Yeo
International Health Division, Menzies School of Health Research and Charles Darwin University, and Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia
J Infect Dis 202:109-12. 2010..P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum... - Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malariaOliver T Mytton
Shoklo Malaria Research Unit, Mae Sot, Thailand
Am J Trop Med Hyg 77:447-50. 2007..At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram... - Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in papua, IndonesiaGraeme P Maguire
International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
J Infect Dis 192:1966-74. 2005..Persistent impairment long after clearance of parasitized RBCs suggests prolonged posttreatment inflammatory alveolar-capillary injury... - Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malariaTsin W Yeo
International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
J Exp Med 204:2693-704. 2007..Clinical trials in SM of adjunctive agents to improve endothelial NO bioavailability, including l-arginine, are warranted... - Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malariaTsin W Yeo
International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin NT 0810, Australia
Proc Natl Acad Sci U S A 105:17097-102. 2008..Agents that improve endothelial NO, reduce WPB exocytosis, and/or antagonize Ang-2 may have therapeutic roles in SM... - Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcomeTsin W Yeo
International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
PLoS Pathog 6:e1000868. 2010..72) in those with SM. ADMA is increased in SM and associated with decreased vascular and pulmonary NO bioavailability. Inhibition of NOS by ADMA may contribute to increased mortality in severe malaria... - Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malariaTsin W Yeo
International Health Division, Menzies School of Health Research and Charles Darwin University, Royal Darwin Hospital, Darwin, NT 0811, Australia
J Infect Dis 200:1522-9. 2009..We examined the relationship of plasma hemoglobin and myoglobin to endothelial dysfunction and disease severity in malaria... - Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammationNicholas M Anstey
International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT 0811, Australia
J Infect Dis 195:589-96. 2007..The mechanisms underlying lung injury in vivax malaria are not well understood. Inflammatory responses to Plasmodium falciparum and P. vivax, to our knowledge, have not previously been compared at an organ level... - Improving case definitions for severe malariaNicholas M Anstey
International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
PLoS Med 4:e267. 2007 - Vivax malaria: neglected and not benignRic N Price
International Health Program, Menzies School of Health Research and Charles Darwin University, Casuarina, Darwin, Northern Territory 0811, Australia
Am J Trop Med Hyg 77:79-87. 2007..Without these, vivax malaria will continue to be neglected by ministries of health, policy makers, researchers, and funding bodies... - Safety profile of L-arginine infusion in moderately severe falciparum malariaTsin W Yeo
International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
PLoS ONE 3:e2347. 2008..We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in adults with moderately severe malaria... - Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrationsTsin W Yeo
International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
J Infect Dis 198:602-8. 2008..L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria... - Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, IndonesiaEmiliana Tjitra
National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
PLoS Med 5:e128. 2008..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia... - Improving the availability of artesunate for treatment of severe malariaNicholas M Anstey
Med J Aust 184:3-4. 2006 - Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of ThailandAnne Catrin Uhlemann
Centre for Infection, Division of Cellular and Molecular Medicine, St George s, University of London, London, United Kingdom
J Infect Dis 195:134-41. 2007..We assessed how administration of different antimalarial drugs altered pfmdr1 polymorphism in parasites from patients who experienced treatment failure... - Simplified antimalarial therapeutic monitoring: using the day-7 drug level?Nicholas J White
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Trends Parasitol 24:159-63. 2008..Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials... - Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberRic N Price
Department of Cellular and Molecular Medicine-Infectious Diseases, St George's Hospital Medical School, London, UK
Lancet 364:438-47. 2004..Monitoring of pfmdr1 copy number will be useful in epidemiological surveys of drug resistance in P falciparum, and potentially for predicting treatment failure in individual patients... - Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemicJeanne Rini Poespoprodjo
District Health Authority, School of Health Research National Institute of Health Research and Development Malaria Research Program, Indonesia
Clin Infect Dis 46:1374-81. 2008..Plasmodium falciparum infection exerts a considerable burden on pregnant women, but less is known about the adverse consequences of Plasmodium vivax infection...