Research Topics
| Michelle NelsonSummaryAffiliation: Porton Down Country: UK Publications
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Detail Information
Publications
Establishment of lethal inhalational infection with Francisella tularensis (tularaemia) in the common marmoset (Callithrix jacchus)Michelle Nelson
Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire, UK
Int J Exp Pathol 90:109-18. 2009..The common marmoset may therefore be considered a suitable model for further studies of inhalational tularaemia...- Post-exposure therapy of inhalational anthrax in the common marmosetMichelle Nelson
Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Int J Antimicrob Agents 38:60-4. 2011..anthracis in a similar way to the macaque, suggesting that this small non-human primate is an acceptable, practical alternative model for the evaluation of medical countermeasures against respiratory anthrax infection... - Bioavailability and efficacy of levofloxacin against Francisella tularensis in the common marmoset (Callithrix jacchus)Michelle Nelson
Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom
Antimicrob Agents Chemother 54:3922-6. 2010..The marmoset appears to be an appropriate animal model for the evaluation of postexposure therapies... - Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosisMichelle Nelson
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 53:1177-82. 2004..This study is the first time antigens protective by active immunization have been identified and suggests that polysaccharides have potential as vaccine candidates against melioidosis... - Characterization of lethal inhalational infection with Francisella tularensis in the common marmoset (Callithrix jacchus)Michelle Nelson
Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
J Med Microbiol 59:1107-13. 2010.... - Experimental acute respiratory Burkholderia pseudomallei infection in BALB/c miceMark S Lever
Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, UK
Int J Exp Pathol 90:16-25. 2009..These results suggest that the BALB/c mouse is highly susceptible to B. pseudomallei by the aerosol route and represents a relevant model system of acute human melioidosis... - Experimental respiratory anthrax infection in the common marmoset (Callithrix jacchus)Mark S Lever
Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire, UK
Int J Exp Pathol 89:171-9. 2008..13 x 10(3) spores in the cynomolgus macaque. This suggests that the common marmoset is an appropriate alternative NHP and will be used for the evaluation of medical countermeasures against respiratory anthrax infection... - Development of an acute model of inhalational melioidosis in the common marmoset (Callithrix jacchus)Michelle Nelson
Biomedical Sciences, Defence Science and Technology Laboratory Dstl, Porton Down, Salisbury, Wiltshire, UK Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK
Int J Exp Pathol 92:428-35. 2011..The common marmoset can therefore be considered a suitable animal model for further studies of inhalational melioidosis... - Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouseM Stephen Lever
Dstl Biomedical Sciences, Porton Down, Salisbury, Wiltshire, UK
J Med Microbiol 52:1109-15. 2003..mallei when delivered by the aerosol route and that this represents a model system of acute human glanders that is suitable for research into the pathogenesis of and vaccines against this disease... - Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesisTimothy Atkins
Defence Science and Technology Laboratory, Salisbury, Wiltshire
J Med Microbiol 51:539-47. 2002..Mice were dosed with the mutant and subsequently challenged with wild-type B. pseudomallei, but the mutant failed to induce a protective immune response... - Development and characterization of mouse models of infection with aerosolized Brucella melitensis and Brucella suisSophie J Smither
Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, United Kingdom
Clin Vaccine Immunol 16:779-83. 2009..We have developed mouse models of infection with aerosolized Brucella melitensis and Brucella suis and demonstrated their utility for the evaluation of vaccines using the model live B. melitensis vaccine strain Rev.1... - Critical role of type 1 cytokines in controlling initial infection with Burkholderia malleiCaroline A Rowland
Biomedical Sciences, Dstl, Porton Down, Salisbury, SP4 0JQ, United Kingdom
Infect Immun 74:5333-40. 2006..Our data show that B. mallei is susceptible to cell-mediated immune responses which promote expression of type 1 cytokines. This suggests that development of effective vaccines against glanders should target the production of IFN-gamma... - Analysis of peptide mimotopes of Burkholderia pseudomallei exopolysaccharideJoseph B Legutki
Department of Microbiology, The Ohio State University, 484 W 12th Ave Rm 376, Columbus, OH 43210, United States
Vaccine 25:7796-805. 2007..00 days over the 2.18 days afforded by immunization with thyroglobulin alone. This mimotope may be of use in developing an antibody response against B. pseudomallei exopolysaccharide... - Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosisDavid N Harland
Department of Molecular Microbiology, School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter, United Kingdom
Infect Immun 75:4173-80. 2007..Immunization with LolC also protected against a subsequent challenge with a heterologous strain of B. pseudomallei, demonstrating the potential utility of this protein as a vaccine antigen for melioidosis... - Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosisMark P Stevens
Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, UK
Microbiology 150:2669-76. 2004..Mice inoculated with the B. pseudomallei bipD mutant were partially protected against subsequent challenge with wild-type B. pseudomallei. However, immunization of mice with purified BipD protein was not protective...