Tim Planche

Summary

Country: UK

Publications

  1. ncbi Severe malaria: metabolic complications
    T Planche
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, London SW17 0RE, UK
    Curr Mol Med 6:141-53. 2006
  2. ncbi Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
  3. ncbi The relevance of malaria pathophysiology to strategies of clinical management
    Tim Planche
    Department of Cellular and Molecular Medicine, Centre for Infection, St George s Hospital Medical School, London SW17 0RE, UK
    Curr Opin Infect Dis 18:369-75. 2005
  4. ncbi Malaria and fluids--balancing acts
    Tim Planche
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, London, UK, SW17 0RE
    Trends Parasitol 21:562-7. 2005
  5. ncbi Metabolic complications of severe malaria
    T Planche
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, Cranmer Terrace, London SW17 ORE, UK
    Curr Top Microbiol Immunol 295:105-36. 2005
  6. ncbi Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children
    Tsiri Agbenyega
    Department of Physiology, University of Science and Technology, School of Medical Sciences, Departments of Child Health and Medicine, Komfo-Anokye Teaching Hospital, Kumasi, Ghana
    J Clin Pharmacol 43:386-96. 2003

Collaborators

  • P W Stacpoole
  • Sanjeev Krishna
  • George Bedu-Addo
  • Arnaud Dzeing-Ella
  • Tsiri Agbenyega
  • Béatrice Mboza
  • Rose Tchoua
  • Ulrich Muller-Roemer
  • Monique Mbounja
  • Eric Kendjo
  • Joseph Jarvis
  • Peter G Kremsner
  • Edouard Ngou-Milama
  • Pascal C Nze Obiang
  • Maryvonne Kombila
  • Venkatesh A Bhattaram
  • Hartmut Derendorf
  • Daniel Ansong
  • Nelamangala V Nagaraja
  • Alex Owusu-Ofori
  • Albert L Shroads
  • George N Henderson
  • Alan D Hutson

Detail Information

Publications6

  1. ncbi Severe malaria: metabolic complications
    T Planche
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, London SW17 0RE, UK
    Curr Mol Med 6:141-53. 2006
    ..Optimising treatments for these complications should be guided by detailed understanding of their underlying pathophysiology, and may help to reduce the intolerably high case fatality rate of severe malaria...
  2. ncbi Severe falciparum malaria in Gabonese children: clinical and laboratory features
    Arnaud Dzeing-Ella
    Department of Parasitology, Mycology and Tropical Medicine, Faculty of Medicine, University of Health Sciences USS, Libreville, Gabon
    Malar J 4:1. 2005
    ..This study examined the prognostic indicators of severe falciparum malaria in Gabonese children...
  3. ncbi The relevance of malaria pathophysiology to strategies of clinical management
    Tim Planche
    Department of Cellular and Molecular Medicine, Centre for Infection, St George s Hospital Medical School, London SW17 0RE, UK
    Curr Opin Infect Dis 18:369-75. 2005
    ..It is sobering, however, that despite many trials over the last quarter of a century all large trials of adjunctive therapy so far have resulted in either increased morbidity or mortality, or both...
  4. ncbi Malaria and fluids--balancing acts
    Tim Planche
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, London, UK, SW17 0RE
    Trends Parasitol 21:562-7. 2005
    ..Lactic acidosis in malaria can be treated safely with dichloroacetate. This intervention could prove useful as an adjunctive therapy aimed at reducing mortality rates in severe malaria...
  5. ncbi Metabolic complications of severe malaria
    T Planche
    Division of Cellular and Molecular Medicine, Centre for Infection, St George s University of London, Cranmer Terrace, London SW17 ORE, UK
    Curr Top Microbiol Immunol 295:105-36. 2005
    ..Several potential treatments for hyperlactataemia have been investigated, but their effect on mortality from severe malaria has not been determined...
  6. ncbi Population kinetics, efficacy, and safety of dichloroacetate for lactic acidosis due to severe malaria in children
    Tsiri Agbenyega
    Department of Physiology, University of Science and Technology, School of Medical Sciences, Departments of Child Health and Medicine, Komfo-Anokye Teaching Hospital, Kumasi, Ghana
    J Clin Pharmacol 43:386-96. 2003
    ..DCA significantly reduces the concentration of blood lactate, an independent predictor of mortality in malaria. Its prospective evaluation in affecting mortality in this disorder appears warranted...