Research Topics
| R J M Iain WilsonSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Detail Information
Publications
Progress with parasite plastidsR J M Iain Wilson
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Mol Biol 319:257-74. 2002..Besides indicating the potential of the parasite plastid for therapeutic intervention, this review exposes many gaps remaining in our knowledge of this intriguing organelle. The rapid progress being made shows no sign of slackening...
Parasite plastids: maintenance and functionsR J M Iain Wilson
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Philos Trans R Soc Lond B Biol Sci 358:155-62; discussion 162-4. 2003..We present experimental evidence for a physical interaction between SufB and its putative partner SufC (ycf16). In both malaria and plants, SufC is encoded in the nucleus and specifies an ATPase that is imported into the plastid...
Spotlight: re-evaluating replicating organellesR J M Iain Wilson
National Institute for Medical Research, London, UK
Protist 154:3-4. 2003
Parasite plastids: approaching the endgameR J M Iain Wilson
National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
Biol Rev Camb Philos Soc 80:129-53. 2005..Attempts to find inhibitors of the plastid organelle of the malaria parasite should be intensified in such programmes...
SufC hydrolyzes ATP and interacts with SufB from Thermotoga maritimaK Rangachari
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
FEBS Lett 514:225-8. 2002..We also present kinetic studies with a recombinant version of SufC from Thermotoga maritima that shows it is an ATPase and that it interacts with SufB in vitro...
Organelle-specific cochaperonins in apicomplexan parasitesShigeharu Sato
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Mol Biochem Parasitol 141:133-143. 2005..The apicomplexan Cpn10 is phylogenetically related to other mitochondrial versions but a significant relationship between apicomplexan Cpn20s and other cochaperonins was not established...
The transcriptome: malariologists ride the waveR J M Iain Wilson
National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Bioessays 26:339-42. 2004..2003)2 discussed below forge a bridge between the genomics and proteomics of P. falciparum. They are likely to act as a fulcrum upon which much future research will turn: for example, the study of regulation and feed-back loops...
The use of DsRED in single- and dual-color fluorescence labeling of mitochondrial and plastid organelles in Plasmodium falciparumShigeharu Sato
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Mol Biochem Parasitol 134:175-9. 2004
The kinetic mechanism of the SufC ATPase: the cleavage step is accelerated by SufBJohn F Eccleston
Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
J Biol Chem 281:8371-8. 2006..In the absence and presence of SufB, mantADP remains more tightly bound to SufC than mantATP. These studies provide a basis for how the SufB and -C proteins interact in the processes involved in regulating iron-sulfur transfer...
Hydrodynamic characterization of the SufBC and SufCD complexes and their interaction with fluorescent adenosine nucleotidesArsen Petrovic
MRC National Institute for Medical Research, London NW7 1AA, United Kingdom
Protein Sci 17:1264-74. 2008..Given that SufB and SufD have 20% sequence identity and similar predicted secondary structures, the different hydrodynamic properties and kinetic mechanisms of the two complexes are discussed...
