Research Topics
Genomes and Genes
Species | James M A TurnerSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Detail Information
Publications
Sex chromosomes make their markJames M A Turner
MRC National Institute for Medical Research Division, Stem Cell Research and Developmental Genetics, London, UK
Chromosoma 114:300-6. 2005- X-inactivation: close encounters of the X kindJames M A Turner
Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Curr Biol 16:R259-61. 2006..Two new studies have shown that the initiation of inactivation is preceded by X chromosome pairing; their results implicate this pairing in the choice and counting functions of X chromosome inactivation... - Meiotic sex chromosome inactivationJames M A Turner
Division of Stem Cell Biology and Developmental Genetics, MRC NIMR, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 134:1823-31. 2007..Furthermore, failure in MSCI is emerging as an important etiological factor in meiotic sterility... - Meiosis 2007--where have we got to and where are we going?James M A Turner
MRC Biomedical NMR Centre, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Chromosome Res 15:517-21. 2007 - Silencing of unsynapsed meiotic chromosomes in the mouseJames M A Turner
Division of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nat Genet 37:41-7. 2005..These findings impact on the interpretation of the relationship between synaptic errors and sterility in mammals and extend our understanding of the biology of Brca1... - Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivationShantha K Mahadevaiah
Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK
J Cell Biol 182:263-76. 2008..Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI... - BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivationJames M A Turner
Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Curr Biol 14:2135-42. 2004..These observations highlight an important role for BRCA1 in recruiting the kinase ATR to XY chromatin at the onset of MSCI and provide compelling evidence that it is ATR that phosphorylates H2AX and triggers MSCI... - Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatidsJames M A Turner
Division of Developmental Genetics and Stem Cell Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Dev Cell 10:521-9. 2006..While this postmeiotic repression occurs after the loss of MSUC-related proteins at the end of prophase, other histone modifications associated with transcriptional repression have by then become established... - Evidence that meiotic sex chromosome inactivation is essential for male fertilityHelene Royo
Department of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Curr Biol 20:2117-23. 2010..Our findings show that MSCI is essential for male meiosis and, as such, provide insight into the differential severity of meiotic mutations' effects on male and female meiosis... - Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMRLouise N Reynard
MRC National Institute for Medical Research, London NW7 1AA, United Kingdom
Biol Reprod 77:329-35. 2007..As a result of these findings, the gene previously known as Xmr is now officially know as Slx, Sycp3-like, X-linked... - Meiotic sex chromosome inactivation in male mice with targeted disruptions of XistJames M A Turner
Division of Developmental Genetics, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Cell Sci 115:4097-105. 2002..However, our finding that MSCI and sex-body formation are unaltered in mice with targeted mutations of Xist that prevent somatic X inactivation suggests that somatic X-inactivation and MSCI occur by fundamentally different mechanisms... - Increased sex chromosome expression and epigenetic abnormalities in spermatids from male mice with Y chromosome deletionsLouise N Reynard
MRC National Institute for Medical Research, London NW7 1AA, UK
J Cell Sci 122:4239-48. 2009..Together, these data show that an MSYq gene regulates sex chromosome gene expression as well as chromatin remodelling in spermatids... - The management of DNA double-strand breaks in mitotic G2, and in mammalian meiosis viewed from a mitotic G2 perspectivePaul S Burgoyne
Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
Bioessays 29:974-86. 2007.... - Using RNA FISH to study gene expression during mammalian meiosisShantha K Mahadevaiah
Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London, UK
Methods Mol Biol 558:433-44. 2009..Here we describe a protocol for carrying out RNA FISH on male meiotic cells, together with detail on the important controls and common problems associated with this technique... - The consequences of asynapsis for mammalian meiosisPaul S Burgoyne
Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
Nat Rev Genet 10:207-16. 2009..Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into the connection between asynapsis and meiotic impairment... - Key features of the X inactivation process are conserved between marsupials and eutheriansShantha K Mahadevaiah
MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Curr Biol 19:1478-84. 2009..We conclude that aspects of the XCI process are more highly conserved in therian mammals than previously thought... - Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary developmentCarles Gaston-Massuet
Neural Development Unit, Institute of Child Health, University College London, London, UK
Dev Biol 324:322-33. 2008..Our research has revealed a role for Six3 in normal pituitary development, which has likely been conserved during evolution as SIX3 is also expressed in the pituitary gland of the human embryo... - Localisation of histone macroH2A1.2 to the XY-body is not a response to the presence of asynapsed chromosome axesSigrid Hoyer-Fender
III Department of Zoology Developmental Biology, University of Gottingen, Humboldtallee 34A, 37073 Gottingen, Germany
J Cell Sci 117:189-98. 2004..MacroH2A1.2 and HP1 beta co-localise to autosomal pericentromeric heterochromatin in spermatocytes. However, the two proteins show temporally and spatially distinct patterns of association to X and Y chromatin... - The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expressionJacob L Mueller
Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 40:794-9. 2008..Thus, not only is the mouse X chromosome enriched for spermatogenesis genes functioning before meiosis, but in addition, approximately 18% of mouse X-linked genes are expressed in postmeiotic cells... - Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?Yael Costa
MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Hum Mol Genet 15:2324-34. 2006..The presence of MAEL in these critical compartments of male germ cells and its interactions provide a link suggesting the involvement of the miRNA pathway in MSUC... - Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytesYuki Takada
RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro, Yokohama, Japan
Development 134:579-90. 2007..Therefore, for the first time, we are able to indicate a functional involvement of Prc1 during the meiotic prophase of male germ cells and a regulatory role of Scmh1 for Prc1, which involves sex chromosomes... - Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatidsPeter J I Ellis
Department of Pathology, Mammalian Molecular Genetics Group, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Hum Mol Genet 14:2705-15. 2005..We therefore propose that this repression and MSCI itself are evolutionary adaptations to maintain a normal sex ratio in the face of X/Y antagonism...