Research Topics
Genomes and Genes
Species | Francois GuillemotSummaryAffiliation: National Institute for Medical Research Country: UK Publications
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Detail Information
Publications
Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cellsEleanor Winpenny
Cambridge Centre for Brain Repair, Robinson Way, CB2 0PY Cambridge, UK
Neural Dev 6:12. 2011..While the diversity and spatio-temporal origin of olfactory bulb (OB) GABAergic interneurons has been studied in detail, much less is known about the subtypes of glutamatergic OB interneurons...- Ascl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalonBei Wang
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati OH 45229, USA
Neural Dev 4:5. 2009..However, the cellular and molecular mechanisms underlying this compensation remain unclear... - Characterization of the proneural gene regulatory network during mouse telencephalon developmentJulia M Gohlke
Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA
BMC Biol 6:15. 2008..The proneural proteins Mash1 and Ngn2 are key cell autonomous regulators of neurogenesis in the mammalian central nervous system, yet little is known about the molecular pathways regulated by these transcription factors... - From cradle to grave: the multiple roles of fibroblast growth factors in neural developmentFrancois Guillemot
Division of Molecular Neurobiology, Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, UK
Neuron 71:574-88. 2011..How FGFs promote the development of the nervous system and maintain its integrity will thus remain an important focus of research in the future... - Cellular and molecular control of neurogenesis in the mammalian telencephalonFrancois Guillemot
Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Curr Opin Cell Biol 17:639-47. 2005.... - Spatial and temporal specification of neural fates by transcription factor codesFrancois Guillemot
National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
Development 134:3771-80. 2007.... - Cortical interneurons refuse to follow the PAKFrancois Guillemot
Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, NW71AA London, UK
Neuron 54:845-7. 2007.... - Cell fate specification in the mammalian telencephalonFrancois Guillemot
National Institute for Medical Research, Mill Hill, London NW74LL, UK
Prog Neurobiol 83:37-52. 2007..Finally, I discuss the many levels of regulation involved in preventing premature astrocyte differentiation during neurogenesis, and later on in controlling the transition from neurogenesis to gliogenesis... - Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamusMichelle Pelling
Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
Dev Biol 349:406-16. 2011..Given the opposing roles of POMC and NPY neurons in regulating food intake, these results indicate that Ngn3 plays a central role in the generation of neuronal populations controlling energy homeostasis in mice... - Neurogenin 2 has an essential role in development of the dentate gyrusChristophe Galichet
Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
Development 135:2031-41. 2008..These data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis... - Neurogenin 2 controls cortical neuron migration through regulation of Rnd2Julian Ik Tsen Heng
Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Nature 455:114-8. 2008..Thus, a proneural protein controls the complex cellular behaviour of cell migration through a remarkably direct pathway involving the transcriptional activation of a small GTP-binding protein... - Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrainJohn Jacob
MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Development 136:2477-85. 2009..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations... - A role for proneural genes in the maturation of cortical progenitor cellsOlivier Britz
Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Cereb Cortex 16:i138-51. 2006..Taken together, these data support a model whereby Ngn2 and Mash1 function together to regulate the zonal distribution of progenitors in the developing neocortex... - Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cellsCeline Zimmer
National Institute for Medical Research NIMR, Medical Research Council MRC, Department of Molecular Neurobiology, London NW7 1AA, UK
Development 137:293-302. 2010..Together, our results shed light on the mechanisms specifying rostral CR cells and further emphasise the crucial role of telencephalic signalling centres in the generation of distinct CR cell populations... - Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motifDiogo S Castro
Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Dev Cell 11:831-44. 2006..We thus propose that Mash1 synergizes with Brn factors to regulate multiple steps of neurogenesis... - Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signalingEmilie Pacary
Division of Molecular Neurobiology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Neuron 69:1069-84. 2011.... - A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targetsDiogo S Castro
Medical Research Council National Institute for Medical Research, Division of Molecular Neurobiology, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Genes Dev 25:930-45. 2011.... - The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytesCarlos M Parras
Division of Molecular Neurobiology, National Institute for Medical Research, London NW7 1AA, United Kingdom
J Neurosci 27:4233-42. 2007.... - Coupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesisLaurent Nguyen
Division of Molecular Neurobiology, National Institute for Medical Research, London, UK
Cell Cycle 5:2314-8. 2006..p27(Kip1) is therefore part of a machinery that couples the multiple events of neurogenesis in the cerebral cortex... - Molecular mechanisms of cortical differentiationFrancois Guillemot
Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
Eur J Neurosci 23:857-68. 2006.... - p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortexLaurent Nguyen
Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Genes Dev 20:1511-24. 2006..Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis... - Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cellsDavid E G McNay
Division of Developmental Neurobiology, Medical Research Council, The National Institute of Medical Research, Mill Hill, London NW7 1AA, UK
Mol Endocrinol 20:1623-32. 2006..These data demonstrate that Mash1 is both required for the generation of ventral neuroendocrine neurons as well as playing a central role in subtype specification of these neurons... - Crucial first steps: the transcriptional control of neuron delaminationEmilie Pacary
Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Neuron 74:209-11. 2012..In this issue of Neuron, Rousso et al. (2012) show that repression of N-cadherin by Foxp transcription factors disrupts apical adherens junctions and triggers neurogenesis...