Research Topics
| John P A LusinguSummaryCountry: UK Publications
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Publications
Spatial variation and socio-economic determinants of Plasmodium falciparum infection in northeastern TanzaniaBruno P Mmbando
National Institute for Medical Research, Tanga Centre, Tanzania
Malar J 10:145. 2011..The risk of P. falciparum infection varies across the country. This study describes the spatial variation and socio-economic determinants of P. falciparum infection in northeastern Tanzania...- A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasmaGerald K K Cham
Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark
Malar J 7:108. 2008..The bead-based assay described here uses the BioPlex100 (BioRad, Hercules, CA, USA) system which can quantify multiple antibodies simultaneously in a small plasma volume... - Rapid screening for glucose-6-phosphate dehydrogenase deficiency and haemoglobin polymorphisms in Africa by a simple high-throughput SSOP-ELISA methodAnders Enevold
Centre for Medical Parasitology, Institute for Medical Microbiology and Immunology, Panum, 24 2, Blegdamsvej 3, 2200 Copenhagen N, Denmark
Malar J 4:61. 2005.... - A progressive declining in the burden of malaria in north-eastern TanzaniaBruno P Mmbando
National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
Malar J 9:216. 2010..Recently, it has been reported that the burden of malaria in some parts of Africa has declined. However, community-based longitudinal data are sparse and the reasons for the apparent decline are not well understood... - Parasite threshold associated with clinical malaria in areas of different transmission intensities in north eastern TanzaniaBruno P Mmbando
Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
BMC Med Res Methodol 9:75. 2009..This however, is likely to be influenced by other factors such as transmission intensity as well as individual level of immunity against malaria... - Acquisition of antibodies to merozoite surface protein 3 among residents of Korogwe, north eastern TanzaniaMethod D Segeja
National Institute for Medical Research, Tanga Medical Research Centre, Tanga, Tanzania
BMC Infect Dis 10:55. 2010..This study aimed at assessing natural acquisition of antibodies to MSP3 in individuals living in an area with different malaria transmission intensity in preparation for malaria vaccine trials... - Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodesJohn P A Lusingu
Centre for Medical Parasitology, Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
Infect Immun 74:2867-75. 2006..89; P = 0.018) but not in Kwamasimba. Antibody levels to the MSP1 constructs and the control CIDR1alpha domain were not associated with morbidity protection. These data strengthen the concept of developing vaccines based on PfEMP1... - Cytophilic antibodies to Plasmodium falciparum glutamate rich protein are associated with malaria protection in an area of holoendemic transmissionJohn P A Lusingu
National Institute for Medical Research, Amani Medical Research Centre, Tanga and Headquarters, Dar es Salaam, Tanzania
Malar J 4:48. 2005..This study was conducted to analyse if a similar relationship could be documented in an area of intense malaria transmission... - Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in Tanzanian children aged 12-24 monthsJohn P A Lusingu
National Institute for Medical Research, Tanga Centre, Tanzania
Malar J 8:163. 2009..A phase Ib dose-escalating study was conducted to assess the vaccine's safety and immunogenicity in children aged 12 to 24 months in Korogwe, Tanzania (ClinicalTrials.gov number: NCT00469651)... - Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern TanzaniaJohn P A Lusingu
National Institute for Medical Research, Amani Medical Research Centre, Amani and NIMR Headquarters, Dar es Salaam, Tanzania
Malar J 3:26. 2004..The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes... - Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern TanzaniaDeus S Ishengoma
National Institute for Medical Research, Tanga Medical Research Centre, P O Box 5004, Tanga, Tanzania
Malar J 10:176. 2011.... - Challenges in malaria control in sub-Saharan Africa: the vaccine perspectiveJohn P A Lusingu
National Institute for Medical Research, Tanga Research Centre, P O Box 5004, Tanga, Tanzania
Tanzan J Health Res 10:253-66. 2008..There is a hope that malaria vaccines could be developed and deployed in malaria endemic communities. This article highlights the challenges of developing and deploying malaria vaccines... - Modeling the relationship between the population prevalence of Plasmodium falciparum malaria and anemiaIlona A Carneiro
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Am J Trop Med Hyg 75:82-9. 2006..Successful validation of our models in other malaria-endemic settings would enable their use for predicting the impact of malaria control interventions on anemia, and for long-term monitoring and surveillance of malaria... - Altitude-dependent and -independent variations in Plasmodium falciparum prevalence in northeastern TanzaniaChris J Drakeley
Joint Malaria Programme, Moshi, Tanzania
J Infect Dis 191:1589-98. 2005..Estimates based on entomological factors lack precision and are not cost-effective to obtain. We tested altitude and rainfall measurements as correlates of transmission intensity in different ecological settings...