Research Topics
| David C WarhurstSummaryAffiliation: London School of Hygiene and Tropical Medicine Country: UK Publications
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Detail Information
Publications
Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquineDavid C Warhurst
HPA Malaria Reference Laboratory, Pathogen Molecular Biology and Biochemistry Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT
Malar J 2:31. 2003..Desethylamodiaquine, the active metabolite of amodiaquine, which has significant activity in chloroquine-resistance, may also act similarly on its own...- Resistance to antifolates in Plasmodium falciparum, the causative agent of tropical malariaDavid C Warhurst
PHLS Malaria Laboratory, London School of Hygiene and Tropical Medicine, London WC1F 7HT
Sci Prog 85:89-111. 2002.... - The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloidsDavid C Warhurst
Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
Malar J 2:26. 2003..In order to kill the malaria parasite, alkaloids must cross the erythrocyte and parasite membranes to accumulate in the acid digestive vacuole where they prevent detoxication of haematin produced during haemoglobin breakdown... - Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phasesDavid C Warhurst
Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, UK
Biochem Pharmacol 73:1910-26. 2007..Importance of LAR for potency against CQ-R parasites probably reflects ability to block efflux by hydrophobic interaction with PfCRT but may relate to beta-haematin inhibition in vacuolar lipid... - Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical propertiesDavid C Warhurst
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
J Antimicrob Chemother 52:188-93. 2003..Where CQ-proguanil prophylaxis is the only option available in a patient on high-dose HCQ treatment, visiting a CQ-resistant area, replacement of the anti-inflammatory regimen by a daily CQ course at a suitable dose should be considered... - Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strainsQuinton L Fivelman
Third Floor ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Antimicrob Agents Chemother 51:2265-7. 2007..Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed... - Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparumQuinton L Fivelman
ITD, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Antimicrob Agents Chemother 48:4097-102. 2004..The relevance of in vitro interactions to in vivo treatment is discussed... - Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, NigeriaQuinton L Fivelman
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Malar J 1:1. 2002..The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously... - Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparumNahla B Gadalla
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
Malar J 9:74. 2010.... - Lysosomes and drug resistance in malariaDavid C Warhurst
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
Lancet 360:1527-9. 2002 - Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunateJ Brian de Souza
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 5:e9867. 2010.... - Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanesMaria del Rayo Camacho
Centre for Pharmacognosy and Phytotherapy, and Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29 39 Brunswick Square, UK
J Nat Prod 65:1457-61. 2002..2 microM against Trypanosoma brucei brucei, and 63.8 microM against Leishmania donovani. Quercetin was found to be inactive against KB cells (IC(50) = 295.8 microM)... - In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalisI Sullayman Adagu
Romark Research Laboratory, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
J Antimicrob Chemother 49:103-11. 2002..vaginalis. The results suggest that resistance mechanisms for metronidazole can be bypassed by nitazoxanide and tizoxanide... - Enhancement of the antiplasmodial activity of quassin by transformation into a gamma-lactoneGeoffrey C Kirby
Centre for Pharmacognosy and Phytotherapy, and Department of Pharmaceutical and Biological Chemistry, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, U.K
J Nat Prod 66:1486-9. 2003..In the course of this work a dimer, neoquassin ether (6), linked at C-16 was also prepared; 6 was found to have weak antiplasmodial activity (IC(50) = 9.7 microM)... - Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in TanzaniaMichael Alifrangis
Centre for Medical Parasitology, Institute of Medical Microbiology and Immunology, University of Copenhagen, Denmark
J Infect Dis 193:1738-41. 2006..Amodiaquine use has increased in the region. The introduction and high prevalence of the SVMNT haplotype may reflect this and may raise concern regarding the use of amodiaquine in artemisinin-based combination therapies in Africa... - PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IXPatrick G Bray
Department of Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Mol Microbiol 62:238-51. 2006..The efflux of CQ in CQR lines is not directly coupled to the energy supply, consistent with a model in which mutant PfCRT functions as a gated channel or pore, allowing charged CQ species to leak out of the DV... - Indole and beta-carboline alkaloids from Geissospermum sericeumJonathan C P Steele
Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3DS, UK
J Nat Prod 65:85-8. 2002..The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line...