Research Topics
| P PerelSummaryAffiliation: London School of Hygiene and Tropical Medicine Country: UK Publications
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Detail Information
Publications
CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trialP Perel
London School of Hygiene and Tropical Medicine, London, UK
Health Technol Assess 16:iii-xii, 1-54. 2012..These findings raise the possibility that it might also be effective in traumatic brain injury (TBI)...- Between-centre differences and treatment effects in randomized controlled trials: a case study in traumatic brain injuryHester F Lingsma
Department of Public Health, Erasmus MC, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
Trials 12:201. 2011..The aim of this study was to assess the influence of between-centre differences in outcome on the estimated treatment effect in a large RCT in TBI... - The added value of ordinal analysis in clinical trials: an example in traumatic brain injuryBob Roozenbeek
Department of Neurosurgery, Antwerp University Hospital, Wilrijkstraat 10, Edegem, Belgium
Crit Care 15:R127. 2011..The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial... - Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluationCarla Guerriero
Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
Cost Eff Resour Alloc 8:1. 2010..In countries where there is a blood shortage, TXA would be a cost effective way to reduce mortality. In countries where there is no blood shortage, TXA would reduce healthcare costs and avert blood borne infections... - Intracranial bleeding in patients with traumatic brain injury: a prognostic studyPablo Perel
Epidemiology and Population Health Department, London School of Hygiene and Tropical Medicine, London, UK
BMC Emerg Med 9:15. 2009..We analysed data from the Trauma Audit & Research Network (TARN), a large European trauma registry, to evaluate the association between the size of IB and mortality in patients with TBI... - Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patientsPablo Perel
London School of Hygiene and Tropical Medicine, London WC1B 3DP
BMJ 336:425-9. 2008..To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury... - Road safety in low- and middle-income countries: a neglected research areaP Perel
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Inj Prev 13:227. 2007 - Use of the Oxford Handicap Scale at hospital discharge to predict Glasgow Outcome Scale at 6 months in patients with traumatic brain injuryPablo Perel
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
BMC Med Res Methodol 8:72. 2008..The objectives of this study were to evaluate the association and predictive validity between a simple disability scale at hospital discharge, the Oxford Handicap Scale (OHS), and the GOS at 6 months among TBI patients... - Comparison of treatment effects between animal experiments and clinical trials: systematic reviewPablo Perel
Crash Trials Coordinating Centre, London School of Hygiene and Tropical Medicine, London WC1E 7HT
BMJ 334:197. 2007..To examine concordance between treatment effects in animal experiments and clinical trials. Study design Systematic review... - Systematic review of prognostic models in traumatic brain injuryPablo Perel
Nutrition and Public Health Intervention Research Unit, Epidemiology and Population Health Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
BMC Med Inform Decis Mak 6:38. 2006..Two reviewers independently examined titles, abstracts and assessed whether each met the pre-defined inclusion criteria... - Noncommunicable diseases and injuries in Latin America and the Caribbean: time for actionPablo Perel
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 3:e344. 2006 - The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trialIan Roberts
Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Lancet 377:1096-101, 1101.e1-2. 2011..Tranexamic acid significantly reduced all-cause mortality. Because tranexamic acid is thought to exert its effect through inhibition of fibrinolysis, we undertook exploratory analyses of its effect on death due to bleeding... - Patient outcome after traumatic brain injury in high-, middle- and low-income countries: analysis of data on 8927 patients in 46 countriesMary J De Silva
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK
Int J Epidemiol 38:452-8. 2009..Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. The burden of TBI is greatest in low- and middle-income countries (LAMIC), yet little is known about patient outcomes in these settings... - How effective are some common treatments for traumatic brain injury?Katharine Ker
Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
BMJ 337:a865. 2008 - Beta-2 receptor antagonists for traumatic brain injury: a systematic review of controlled trials in animal modelsK Ker
NPHIRU, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
CNS Neurosci Ther 15:52-64. 2009..However, the poor methodological quality of the included studies and presence of small study effects may have influenced these findings... - Relation between the global burden of disease and randomized clinical trials conducted in Latin America published in the five leading medical journalsPablo Perel
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 3:e1696. 2008..We analyzed the relationship between the global burden of disease and Randomized Clinical Trials (RCTs) conducted in Latin America that were published in the five leading medical journals... - Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trialHaleema Shakur
Clinical Trials Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Lancet 376:23-32. 2010..We assessed the effects of early administration of a short course of tranexamic acid on death, vascular occlusive events, and the receipt of blood transfusion in trauma patients... - Research on preventing road traffic injuries in developing countries is neededPablo Perel
BMJ 328:895. 2004 - Prognosis following head injury: a survey of doctors from developing and developed countriesPablo Perel
J Eval Clin Pract 13:464-5. 2007 - Household wealth and the metabolic syndrome in the Whitehall II studyPablo Perel
International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, U.K
Diabetes Care 29:2694-700. 2006..Future research should explore the potential mechanisms by which wealth inequalities are associated with the metabolic syndrome... - Evidence-based medicine in Iberoamerica: problems and possible solutionsZulma Ortiz
PLoS Med 2:e277. 2005