D Mabey

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. ncbi Diagnostics for the developing world
    David Mabey
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7H, UK
    Nat Rev Microbiol 2:231-40. 2004
  2. ncbi A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 7:40. 2006
  3. ncbi Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 10:138. 2009
  4. ncbi The epidemic of sexually transmitted infections in China: implications for control and future perspectives
    Xiang Sheng Chen
    National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China
    BMC Med 9:111. 2011
  5. ncbi Application of molecular tools in the control of blinding trachoma
    David Mabey
    Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 69:11-7. 2003
  6. ncbi Trichomonas vaginalis infection
    D Mabey
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Sex Transm Infect 82:iv26-7. 2006
  7. ncbi Trachoma
    David C W Mabey
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Lancet 362:223-9. 2003
  8. ncbi Trachoma: recent developments
    David Mabey
    London School of Hygiene and Tropical Medicine
    Adv Exp Med Biol 609:98-107. 2008
  9. ncbi Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis
    D Mabey
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:v13-6. 2006
  10. ncbi Lymphogranuloma venereum
    D Mabey
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Sex Transm Infect 78:90-2. 2002

Collaborators

Detail Information

Publications81

  1. ncbi Diagnostics for the developing world
    David Mabey
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7H, UK
    Nat Rev Microbiol 2:231-40. 2004
  2. ncbi A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 7:40. 2006
    ..Genetic variation within the MMP9 gene affects in vitro MMP9 expression levels, enzymatic activity and susceptibility to various inflammatory and fibrotic conditions...
  3. ncbi Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 10:138. 2009
    ....
  4. ncbi The epidemic of sexually transmitted infections in China: implications for control and future perspectives
    Xiang Sheng Chen
    National Center for STD Control, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology, Nanjing, China
    BMC Med 9:111. 2011
    ..Programmes for the control of STIs should be immediate priorities in China, and primary and secondary prevention strategies are vital to this process...
  5. ncbi Application of molecular tools in the control of blinding trachoma
    David Mabey
    Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 69:11-7. 2003
    ..In addition, the contribution of genotyping to our understanding of the epidemiology and biology of C. trachomatis is considered...
  6. ncbi Trichomonas vaginalis infection
    D Mabey
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Sex Transm Infect 82:iv26-7. 2006
  7. ncbi Trachoma
    David C W Mabey
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Lancet 362:223-9. 2003
    ..By means of the SAFE strategy, WHO and its partners aim to eliminate trachoma as a public-health problem by the year 2020...
  8. ncbi Trachoma: recent developments
    David Mabey
    London School of Hygiene and Tropical Medicine
    Adv Exp Med Biol 609:98-107. 2008
  9. ncbi Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis
    D Mabey
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:v13-6. 2006
    ..To evaluate prospectively four rapid, point-of-care serological tests for syphilis in prenatal or high risk populations in four countries...
  10. ncbi Lymphogranuloma venereum
    D Mabey
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Sex Transm Infect 78:90-2. 2002
    ..It is rare in industrialised countries, but is endemic in parts of Africa, Asia, South America, and the Caribbean. We discuss its clinical features, diagnosis, and management...
  11. ncbi Interactions between HIV infection and other sexually transmitted diseases
    D Mabey
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 5:A32-6. 2000
    ..Mechanisms and implications of the interaction between HIV and other STDs such as syphilis, Herpes simplex, Chlamydia and Neisseria gonorrhoeae infection are presented and relevant case reports and trials described...
  12. ncbi What have we learned from sexually transmitted infection research in sub-Saharan Africa?
    David Mabey
    Department of Infectious andTropical Diseases, LondonSchool of Hygiene and TropicalMedicine, London, UK
    Sex Transm Infect 86:488-92. 2010
    ..This review summarises the major achievements of STI researchers in Africa in the past 30 years, and discusses the reasons underlying the success of STI research in Africa...
  13. ncbi Modelling the cost-effectiveness of introducing rapid syphilis tests into an antenatal syphilis screening programme in Mwanza, Tanzania
    P Vickerman
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Sex Transm Infect 82:v38-43. 2006
    ..This analysis estimates the relative cost-effectiveness of using these POC tests in the Mwanza syphilis screening intervention...
  14. ncbi Modelling the cost effectiveness of rapid point of care diagnostic tests for the control of HIV and other sexually transmitted infections among female sex workers
    P Vickerman
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:403-12. 2006
    ....
  15. ncbi The burden and determinants of HIV and sexually transmitted infections in a population-based sample of female sex workers in Goa, India
    M Shahmanesh
    Centre for Sexual Health and HIV Research, University College London, London, UK
    Sex Transm Infect 85:50-9. 2009
    ..Understanding the way in which societal and individual factors interact to shape sex workers' vulnerability would better inform interventions...
  16. ncbi Spousal sexual violence and poverty are risk factors for sexually transmitted infections in women: a longitudinal study of women in Goa, India
    H A Weiss
    Department of Epidemiology and Population Health, Keppel Street, London, WC1E 7HT, UK
    Sex Transm Infect 84:133-9. 2008
    ..To describe factors associated with incident sexually transmitted infections (STI) in a population-based sample of women in Goa, India...
  17. ncbi Operational performance of an STD control programme in Mwanza Region, Tanzania
    H Grosskurth
    London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 76:426-36. 2000
    ....
  18. ncbi Control of sexually transmitted diseases for HIV-1 prevention: understanding the implications of the Mwanza and Rakai trials
    H Grosskurth
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Lancet 355:1981-7. 2000
    ..Implications of the trials for policy and future research agenda are discussed...
  19. ncbi Is antenatal syphilis screening still cost effective in sub-Saharan Africa
    F Terris-Prestholt
    London School of Hygiene and Tropical Medicine, London, UK
    Sex Transm Infect 79:375-81. 2003
    ..To compare this intervention with other antenatal and child health interventions, specifically the prevention of mother to child transmission of HIV (PMTCT)...
  20. ncbi Adverse birth outcomes in United Republic of Tanzania--impact and prevention of maternal risk factors
    Deborah Watson Jones
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, England
    Bull World Health Organ 85:9-18. 2007
    ..To determine risk factors for poor birth outcome and their population attributable fractions...
  21. ncbi A study comparing sexually transmitted infections and HIV among ex-red-light district and non-red-light district sex workers after the demolition of Baina red-light district
    Maryam Shahmanesh
    Centre for Sexual Health and HIV Research, University College London, London, United Kingdom
    J Acquir Immune Defic Syndr 52:253-7. 2009
    ..We compare HIV and sexually transmitted infections (STIs) between sex workers who had been based in Baina red-light district (ex-RLD-SWs) with sex workers who had never worked in Baina (non-RLD-SWs)...
  22. ncbi Point-of-care tests for diagnosing infections in the developing world
    R W Peeling
    Diagnostic Research, London School of Hygiene and Tropical Medicine, London, UK
    Clin Microbiol Infect 16:1062-9. 2010
    ..Continuing advocacy and training in the use of POC tests are needed, and systems for quality control of POC tests need to be developed if they are to achieve their maximum potential...
  23. ncbi Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis
    Gabriele Riedner
    London School of Hygiene and Tropical Medicine, London
    N Engl J Med 353:1236-44. 2005
    ..4-MU intramuscular dose of penicillin G benzathine in the prevention and treatment of syphilis. We evaluated the efficacy of treatment with azithromycin in a developing country...
  24. ncbi The management of pelvic inflammatory disease in the Central Region of Ghana is not standardized
    W K Bosu
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Int J STD AIDS 9:408-13. 1998
    ..The findings provide the basis for improving the management of PID in the Central Region of Ghana...
  25. ncbi Approaches to the control of sexually transmitted infections in developing countries: old problems and modern challenges
    P Mayaud
    London School of Hygiene and Tropical Medicine, London, UK
    Sex Transm Infect 80:174-82. 2004
    ..The challenge is not just to develop new interventions, but to identify barriers to the implementation of existing tools, and to devise strategies for ensuring that effective STI control programmes are implemented in the future...
  26. ncbi Comparison of latex agglutination, wet preparation, and culture for the detection of Trichomonas vaginalis
    Y Adu-Sarkodie
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 80:201-3. 2004
    ..To compare the performance of three diagnostic methods for Trichomonas vaginalis infection-latex agglutination, saline wet mount, and culture...
  27. ncbi Efficacy of oral azithromycin versus topical tetracycline in mass treatment of endemic trachoma
    N Fraser Hurt
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, London, England
    Bull World Health Organ 79:632-40. 2001
    ..02; 95% CI = 1.42, 3.50). CONCLUSION: Oral azithromycin therefore appears to offer a means for controlling blinding trachoma. It is easy to administer and higher coverages may be possible than have been achieved hitherto...
  28. ncbi Reproductive-tract infections in women in low-income, low-prevalence situations: assessment of syndromic management in Matlab, Bangladesh
    S Hawkes
    International Centre for Diarrhoeal Disease Research, and Centre for Health and Population Research, Bangladesh
    Lancet 354:1776-81. 1999
    ..This intervention was initially developed in areas where prevalence of such infections is high. We investigated the clinical effectiveness and cost of this approach among a group of women with a low prevalence of infection...
  29. ncbi Risk factors for common mental disorders in women. Population-based longitudinal study
    Vikram Patel
    London School of Hygiene and Tropical Medicine, London, UK
    Br J Psychiatry 189:547-55. 2006
    ..The determinants of common mental disorders in women have not been described in longitudinal studies from a low-income country...
  30. ncbi Risk factors influencing HIV infection incidence in a rural African population: a nested case-control study
    James Todd
    London School of Hygiene and Tropical Medicine, UK
    J Infect Dis 193:458-66. 2006
    ....
  31. ncbi Mapping the global distribution of trachoma
    Sarah Polack
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, England
    Bull World Health Organ 83:913-9. 2005
    ..Until now, information on trachoma prevalence at within country levels has not been systematically collated, analysed and reported...
  32. ncbi Effect of herpes simplex suppression on incidence of HIV among women in Tanzania
    Deborah Watson-Jones
    London School of Hygiene and Tropical Medicine, London
    N Engl J Med 358:1560-71. 2008
    ..This study tested the hypothesis that HSV-2 suppressive therapy reduces the risk of HIV acquisition...
  33. ncbi Prioritizing health problems in women in developing countries: comparing the financial burden of reproductive tract infections, anaemia and depressive disorders in a community survey in India
    Vikram Patel
    London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 12:130-9. 2007
    ....
  34. ncbi The relationship between prevalence of active trachoma, water availability and its use in a Tanzanian village
    Sarah Polack
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trans R Soc Trop Med Hyg 100:1075-83. 2006
    ..The key element in the relationship between water availability and trachoma is the allocation of water within households. Collection time may influence both the quantity of water collected and its allocation within the household...
  35. ncbi Gender disadvantage and reproductive health risk factors for common mental disorders in women: a community survey in India
    Vikram Patel
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, England
    Arch Gen Psychiatry 63:404-13. 2006
    ..Gender disadvantage and reproductive health are major determinants of women's health in developing countries...
  36. ncbi Why do women complain of vaginal discharge? A population survey of infectious and pyschosocial risk factors in a South Asian community
    Vikram Patel
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Epidemiol 34:853-62. 2005
    ..Although presumed to be caused by reproductive tract infections (RTIs), the association between the complaint and the presence of RTIs is weak. This study aimed to investigate the risk factors of the complaint of vaginal discharge...
  37. ncbi A critical review of the SAFE strategy for the prevention of blinding trachoma
    Hannah Kuper
    Clinical Research Unit, Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Infect Dis 3:372-81. 2003
    ..The evidence for an effect of health education and environmental improvement is weaker, and depends mostly on cross-sectional observational studies...
  38. ncbi Common genital complaints in women: the contribution of psychosocial and infectious factors in a population-based cohort study in Goa, India
    Vikram Patel
    London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Int J Epidemiol 35:1478-85. 2006
    ..Method Population-based cohort study in Goa, India. Out of 3000 randomly selected women, 2494 women participated. The outcome was an incident case of the complaint of abnormal vaginal discharge at 6 months (T1) and 12 months (T2) review...
  39. ncbi Syphilis in pregnancy in Tanzania. I. Impact of maternal syphilis on outcome of pregnancy
    Deborah Watson-Jones
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 186:940-7. 2002
    ..Syphilis continues to be a major cause of pregnancy loss and adverse pregnancy outcome among women who do not receive antenatal syphilis screening and treatment...
  40. ncbi Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes
    Deborah Watson-Jones
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 186:948-57. 2002
    ..4-1.4) or low-titer active syphilis (OR, 0.95; 95% CI, 0.6-1.5), compared with seronegative women. Single-dose treatment is effective in preventing adverse pregnancy outcomes attributable to maternal syphilis...
  41. ncbi Chronic fatigue in developing countries: population based survey of women in India
    Vikram Patel
    London School of Hygiene and Tropical Medicine, London WC1E 7HT
    BMJ 330:1190. 2005
    ..To describe the prevalence of and risk factors for chronic fatigue in a developing country; in particular, to determine the association of anaemia, mental health, and gender disadvantage factors with chronic fatigue...
  42. ncbi Participatory evaluations of trachoma control programmes in eight countries
    Hannah Kuper
    London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 10:764-72. 2005
    ..Trachoma is a major cause of blindness. The objective of this initiative was to conduct participatory process evaluations of the trachoma control programmes receiving support from the International Trachoma Initiative in eight countries...
  43. ncbi Antenatal syphilis screening in sub-Saharan Africa: lessons learned from Tanzania
    Deborah Watson-Jones
    London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 10:934-43. 2005
    ....
  44. ncbi Reproductive tract infections: prevalence and risk factors in rural Bangladesh
    Sarah Hawkes
    Public Health Sciences Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
    Bull World Health Organ 80:180-8. 2002
    ..To determine the prevalence of and risk factors for reproductive tract infections among men and women in a rural community in Bangladesh...
  45. ncbi Is sexual contact with sex workers important in driving the HIV epidemic among men in rural Zimbabwe?
    Frances M Cowan
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, London, United Kingdom
    J Acquir Immune Defic Syndr 40:371-6. 2005
    ....
  46. ncbi Geographical variations in the prevalence of HIV and other sexually transmitted infections in rural Tanzania
    Henrica A F M Jansen
    London School of Hygiene and Tropical Medicine, London, UK
    Int J STD AIDS 14:274-80. 2003
    ..Differences in transmission dynamics may lead to geographical patterns that vary between STIs...
  47. ncbi Lack of effectiveness of syndromic management in targeting vaginal infections in pregnancy in Entebbe, Uganda
    C J Tann
    London School of Hygiene and Tropical Medicine, London, UK
    Sex Transm Infect 82:285-9. 2006
    ....
  48. ncbi The burden and determinants of reproductive tract infections in India: a population based study of women in Goa, India
    V Patel
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 82:243-9. 2006
    ..Reproductive tract infections (RTI) present major health, social, and economic problems in developing countries. Our objective was to describe the prevalence and risk factors of RTIs in a population based sample of women aged 18-45 years...
  49. ncbi Sensitivity requirements for the point of care diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae in women
    P Vickerman
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Sex Transm Infect 79:363-7. 2003
    ..This study estimates the required sensitivity of POC tests that ensures as many STIs are averted as with current gold standard tests...
  50. ncbi The appropriateness of core group interventions using presumptive periodic treatment among rural Zimbabwean women who exchange sex for gifts or money
    Frances M Cowan
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, London, UK
    J Acquir Immune Defic Syndr 38:202-7. 2005
    ..The prevalence of bacterial STIs was low, suggesting that PPT may not be an appropriate intervention in this setting. Rapid reinfection after PPT suggests that this needs to be given at monthly intervals to reduce prevalence of STIs...
  51. ncbi Effectiveness of interventions for the prevention of HIV and other sexually transmitted infections in female sex workers in resource poor setting: a systematic review
    Maryam Shahmanesh
    Centre for Sexual Health and HIV Research, University College London, London, UK
    Trop Med Int Health 13:659-79. 2008
    ..To systematically review the evidence for effectiveness of HIV and sexually transmitted infection (STI) prevention interventions in female sex workers in resource poor settings...
  52. ncbi The availability and cost of antibiotics for treating PID in the Central Region of Ghana and implications for compliance with national treatment guidelines
    W K Bosu
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
    Int J STD AIDS 9:551-3. 1998
    ..Recommended anti-gonococcal antibiotics (ciprofloxacin, ceftriaxone) may not be prescribed if they are not available in the districts...
  53. ncbi Use of antenatal services and delivery care in Entebbe, Uganda: a community survey
    Carolyn J Tann
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    BMC Pregnancy Childbirth 7:23. 2007
    ....
  54. ncbi Detection of gonococcal infection : pros and cons of a rapid test
    Peter Vickerman
    London School of Hygiene and Tropical Medicine, London, UK
    Mol Diagn 9:175-9. 2005
    ..Their optimal use in these settings requires the development of simpler and cheaper rapid tests...
  55. ncbi Association of schistosomiasis with false-positive HIV test results in an African adolescent population
    Dean B Everett
    London School of Hygiene and Tropical Medicine, London, UK
    J Clin Microbiol 48:1570-7. 2010
    ..In Africa, endemic infections may affect the specificities of immunoassays for HIV infection. Caution should be used when the results of 4th-generation HIV test results are interpreted for African adolescent populations...
  56. ncbi Bacterial infection and trachoma in the gambia: a case control study
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 48:4440-4. 2007
    ..This study was undertaken to investigate whether trachomatous trichiasis or conjunctival scarring are associated with increased prevalence of bacterial infection...
  57. ncbi Two doses of azithromycin to eliminate trachoma in a Tanzanian community
    Anthony W Solomon
    N Engl J Med 358:1870-1. 2008
  58. ncbi Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation
    Angels Natividad
    Infectious and Tropical Diseases Department, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Hum Mol Genet 17:323-9. 2008
    ..0001). These findings provide a plausible functional explanation for the observed genetic association, and support the hypothesis that an excessive IL10 response to C. trachomatis infection is a risk factor for scarring and blindness...
  59. ncbi Absence of Mycoplasma genitalium in eye samples from a trachoma-endemic area of Tanzania
    Jacques Pepin
    Br J Ophthalmol 92:435. 2008
  60. ncbi Acceptability of azithromycin for the control of trachoma in Northern Tanzania
    Nicola Desmond
    MRC Social and Public Health Sciences Unit, 4 Lilybank Gardens, Glasgow G12 8RG, UK
    Trans R Soc Trop Med Hyg 99:656-63. 2005
    ....
  61. ncbi Strategies for control of trachoma: observational study with quantitative PCR
    Anthony W Solomon
    London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
    Lancet 362:198-204. 2003
    ..Success of antibiotic distribution programmes could depend on these groups receiving effective treatment...
  62. ncbi Impact of azithromycin administration for trachoma control on the carriage of antibiotic-resistant Streptococcus pneumoniae
    Sarah L Batt
    Department of Medical Microbiology, University College London, Royal Free Campus, London NW3 2PF
    Antimicrob Agents Chemother 47:2765-9. 2003
    ..0001, Fisher's exact). These data suggest that in communities where macrolide resistance is rare, azithromycin distribution for trachoma control is unlikely to increase the prevalence of resistant organisms...
  63. ncbi Mass treatment with single-dose azithromycin for trachoma
    Anthony W Solomon
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom
    N Engl J Med 351:1962-71. 2004
    ..Trachoma, caused by repeated ocular infection with Chlamydia trachomatis, is an important cause of blindness. Current recommended dosing intervals for mass azithromycin treatment for trachoma are based on a mathematical model...
  64. ncbi Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
    Infect Immun 72:7352-6. 2004
    ..Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present...
  65. ncbi Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 365:1321-8. 2005
    ..We measured the effect of mass treatment on the conjunctival burden of Chlamydia trachomatis in a Gambian community with low to medium trachoma prevalence and investigated the rate, route, and determinants of re-emergent infection...
  66. ncbi Infection with Chlamydia trachomatis after mass treatment of a trachoma hyperendemic community in Tanzania: a longitudinal study
    Sheila K West
    Dana Center for Preventive Ophthalmology, Johns Hopkins University, Baltimore, MD, USA
    Lancet 366:1296-300. 2005
    ....
  67. ncbi Impact of mass distribution of azithromycin on the antibiotic susceptibilities of ocular Chlamydia trachomatis
    Anthony W Solomon
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 49:4804-6. 2005
    ..No clinically or programmatically significant increase in azithromycin or tetracycline resistance was observed...
  68. ncbi Conjunctival chlamydial 16S ribosomal RNA expression in trachoma: is chlamydial metabolic activity required for disease to develop?
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Infect Dis 42:463-70. 2006
    ..We measured chlamydial 16S ribosomal RNA (rRNA) expression, a marker of chlamydial metabolic activity, in comparison with the quantitation of a chlamydial DNA target in subjects exposed to trachoma...
  69. ncbi The frequency of Chlamydia trachomatis major outer membrane protein-specific CD8+ T lymphocytes in active trachoma is associated with current ocular infection
    Martin J Holland
    Medical Research Council Laboratories, Banjul, The Gambia
    Infect Immun 74:1565-72. 2006
    ..trachomatis infection at the time of sample collection. High frequencies of C. trachomatis-specific cells did not predict subsequent appearance or resolution of the clinical disease signs of active trachoma...
  70. ncbi Operational evaluation of the use of photographs for grading active trachoma
    Anthony W Solomon
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 74:505-8. 2006
    ..Either the signs TF and TI themselves are not as reliable as previously believed, or photographs should be used for their diagnosis only when reliability testing demonstrates better agreement than found here...
  71. ncbi Clinical examination versus Chlamydia trachomatis assays to guide antibiotic use in trachoma control programmes
    Anthony W Solomon
    Lancet Infect Dis 6:5-6; author reply 7-8. 2006
  72. ncbi Genital human papillomavirus genotypes in northwestern Tanzania
    Philippe Mayaud
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    J Clin Microbiol 41:4451-3. 2003
    ..A multivalent vaccine for HPV-16, -18, -31, -33, and -35 would be necessary to prevent 50% of the neoplasia in this population...
  73. ncbi Which members of a community need antibiotics to control trachoma? Conjunctival Chlamydia trachomatis infection load in Gambian villages
    Matthew J Burton
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:4215-22. 2003
    ....
  74. ncbi Diagnosis and assessment of trachoma
    Anthony W Solomon
    Clinical Research Unit, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
    Clin Microbiol Rev 17:982-1011, table of contents. 2004
    ..There is an urgent need for a rapid, reliable test for C. trachomatis to assist in measuring progress towards the elimination of trachoma...
  75. ncbi Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection?
    Nkoyo Faal
    Medical Research Council Laboratories, Fajara, Banjul, Gambia
    PLoS Med 3:e266. 2006
    ..This is essential for the successful development of a vaccine against both ocular and genital C. trachomatis infection...
  76. ncbi The long-term natural history of trachomatous trichiasis in the Gambia
    Matthew J Burton
    International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Invest Ophthalmol Vis Sci 47:847-52. 2006
    ..Trachoma is the leading infectious cause of blindness. However, there are few data on the natural history of trachomatous trichiasis to guide program planning or that investigate its pathogenesis...
  77. ncbi Field evaluation of a rapid point-of-care assay for targeting antibiotic treatment for trachoma control: a comparative study
    Claude-Edouard C Michel
    Diagnostics Development Unit, Department of Haematology, University of Cambridge, Cambridge, UK
    Lancet 367:1585-90. 2006
    ..Additional studies should assess the use of the assay in the planning and monitoring of trachoma control activities...
  78. ncbi Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations
    Laszlo Kari
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    J Infect Dis 197:449-56. 2008
    ..Our findings are the first to identify genes that correlate with differences in pathogenicity among trachoma strains...
  79. ncbi Cervicovaginal HIV-1 and herpes simplex virus type 2 shedding during genital ulcer disease episodes
    Jerome Legoff
    Université Paris Descartes Equipe Immunité et Biothérapie Muqueuse, Unité INSERM Internationale U743 Immunologie Humaine, Centre de Recherches Biomedicales des Cordeliers, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    AIDS 21:1569-78. 2007
    ..To investigate correlates of herpes simplex virus type 2 (HSV-2) DNA and HIV-1 RNA among women with genital ulcer disease (GUD)...
  80. ncbi Modeling the economic net benefit of a potential vaccination program against ocular infection with Chlamydia trachomatis
    Anthony W Solomon
    Vaccine 23:5281-2. 2005