Research Topics
Species | Matthew J BurtonSummaryAffiliation: London School of Hygiene and Tropical Medicine Country: UK Publications
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Detail Information
Publications
The long-term natural history of trachomatous trichiasis in the GambiaMatthew J Burton
International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
Invest Ophthalmol Vis Sci 47:847-52. 2006..Trachoma is the leading infectious cause of blindness. However, there are few data on the natural history of trachomatous trichiasis to guide program planning or that investigate its pathogenesis...- Trichiasis surgery in The Gambia: a 4-year prospective studySaul N Rajak
London School of Hygiene and Tropical Medicine, London, UK
Invest Ophthalmol Vis Sci 51:4996-5001. 2010..Although trichiasis surgery can reduce the risk of blindness, retrospective data suggest that long-term recurrence rates may be high. A 4-year prospective investigation of recurrent trichiasis was conducted in The Gambia... - Conjunctival expression of matrix metalloproteinase and proinflammatory cytokine genes after trichiasis surgeryMatthew J Burton
London School of Hygiene and Tropical Medicine, London, United Kingdom
Invest Ophthalmol Vis Sci 51:3583-90. 2010..Prospective studies are needed to assess the potential importance of these and other factors in progressive disease... - Which members of a community need antibiotics to control trachoma? Conjunctival Chlamydia trachomatis infection load in Gambian villagesMatthew J Burton
London School of Hygiene and Tropical Medicine, London, United Kingdom
Invest Ophthalmol Vis Sci 44:4215-22. 2003.... - Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal studyMatthew J Burton
London School of Hygiene and Tropical Medicine, London, UK
Lancet 365:1321-8. 2005..We measured the effect of mass treatment on the conjunctival burden of Chlamydia trachomatis in a Gambian community with low to medium trachoma prevalence and investigated the rate, route, and determinants of re-emergent infection... - What is causing active trachoma? The role of nonchlamydial bacterial pathogens in a low prevalence settingMatthew J Burton
Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
Invest Ophthalmol Vis Sci 52:6012-7. 2011..This study investigated the relationship between TF, C. trachomatis, and nonchlamydial bacterial infection... - Bacterial infection and trachoma in the gambia: a case control studyMatthew J Burton
International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
Invest Ophthalmol Vis Sci 48:4440-4. 2007..This study was undertaken to investigate whether trachomatous trichiasis or conjunctival scarring are associated with increased prevalence of bacterial infection... - Targeting antibiotics to households for trachoma controlIsobel M Blake
Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
PLoS Negl Trop Dis 4:e862. 2010..Here we explore whether alternative, targeted approaches are effective antibiotic-sparing strategies... - Conjunctival chlamydial 16S ribosomal RNA expression in trachoma: is chlamydial metabolic activity required for disease to develop?Matthew J Burton
London School of Hygiene and Tropical Medicine, London, United Kingdom
Clin Infect Dis 42:463-70. 2006..We measured chlamydial 16S ribosomal RNA (rRNA) expression, a marker of chlamydial metabolic activity, in comparison with the quantitation of a chlamydial DNA target in subjects exposed to trachoma... - Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infectionAngels Natividad
Department of Clinical Research, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
Infect Immun 78:4895-911. 2010..The data suggest that in addition to polymorph and adaptive cellular responses, NK cells may contribute to a significant component of the conjunctival inflammatory response to chlamydial infection... - The clinical phenotype of trachomatous trichiasis in Ethiopia: not all trichiasis is due to entropionSaul N Rajak
The London School of Hygiene and Tropical Medicine, London, United Kingdom
Invest Ophthalmol Vis Sci 52:7974-80. 2011..This variation in clinical phenotype is potentially important for treatment guidelines. Therefore, this study was conducted to investigate the range of disease type and severity encompassed by TT... - Active Trachoma Is Associated with Increased Conjunctival Expression of IL17A and Profibrotic CytokinesMatthew J Burton
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Infect Immun 79:4977-83. 2011..Its activity may be promoted either as part of the cell-mediated response or through innate pathways. It may drive a range of proinflammatory factors leading to excessive tissue damage and repair involving fibrosis... - In vivo confocal microscopy in scarring trachomaVictor H Hu
International Centre for Eye Health, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Kilimanjaro Centre for Community Ophthalmology, Moshi, Tanzania
Ophthalmology 118:2138-46. 2011..To characterize the tissue and cellular changes found in trachomatous scarring (TS) and inflammation using in vivo confocal microscopy (IVCM)... - Epilation for trachomatous trichiasis and the risk of corneal opacificationSaul N Rajak
The London School of Hygiene and Tropical Medicine, London, United Kingdom
Ophthalmology 119:84-9. 2012..However, epilation is widely practiced for treating minor TT (1-5 lashes touching the globe). We report the frequency and effectiveness of patient-initiated epilation and its relationship to corneal opacity... - Strategies for control of trachoma: observational study with quantitative PCRAnthony W Solomon
London School of Hygiene and Tropical Medicine, WC1E 7HT, London, UK
Lancet 362:198-204. 2003..Success of antibiotic distribution programmes could depend on these groups receiving effective treatment... - Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasisMartin J Holland
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
Invest Ophthalmol Vis Sci 51:3893-902. 2010..The purpose was to identify genes that are differentially expressed in the upper tarsal conjunctiva of subjects with TT... - Absorbable versus silk sutures for surgical treatment of trachomatous trichiasis in Ethiopia: a randomised controlled trialSaul N Rajak
The London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 8:e1001137. 2011..Trichiasis can recur after corrective surgery. We tested the hypothesis that using absorbable sutures instead of silk sutures might reduce the risk of recurrent disease among patients with major trichiasis in a randomised trial... - Chlamydia trachomatis ompA variants in trachoma: what do they tell us?Aura A Andreasen
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Negl Trop Dis 2:e306. 2008..Sequence-based analysis of the multiple strains typically present in endemic communities may be informative for epidemiology, transmission, response to treatment, and understanding the host response... - The development of an age-structured model for trachoma transmission dynamics, pathogenesis and controlManoj Gambhir
Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
PLoS Negl Trop Dis 3:e462. 2009..We present an age-structured mathematical model of trachoma transmission and disease to predict the impact of interventions on the prevalence of blinding trachoma... - Bacterial infection in scarring trachomaVictor H Hu
International Centre for Eye Health, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Invest Ophthalmol Vis Sci 52:2181-6. 2011..To assess whether non-chlamydial bacterial infection is associated with trachomatous scarring in adults... - Surgery versus epilation for the treatment of minor trichiasis in Ethiopia: a randomised controlled noninferiority trialSaul N Rajak
The London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Med 8:e1001136. 2011..This trial investigated whether epilation is noninferior to surgery for managing minor trichiasis... - In vivo confocal microscopy of trachoma in relation to normal tarsal conjunctivaVictor H Hu
International Centre for Eye Health, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Ophthalmology 118:747-54. 2011.... - Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemicMatthew J Burton
International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
Infect Immun 72:7352-6. 2004..Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present... - A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infectionAngels Natividad
London School of Hygiene and Tropical Medicine, London University, London, UK
BMC Med Genet 7:40. 2006..Genetic variation within the MMP9 gene affects in vitro MMP9 expression levels, enzymatic activity and susceptibility to various inflammatory and fibrotic conditions... - Conjunctival transcriptome in scarring trachomaMatthew J Burton
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Infect Immun 79:499-511. 2011.... - Epidemiology and control of trachoma: systematic reviewVictor H Hu
London School of Hygiene and Tropical Medicine, UK
Trop Med Int Health 15:673-91. 2010..This has been associated with significant reductions in the prevalence of active disease over the past 20 years, but there remain a large number of people with trichiasis who are at risk of blindness... - The global burden of trachoma: a reviewMatthew J Burton
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Negl Trop Dis 3:e460. 2009..3 million Disability-Adjusted Life Years (DALYs). A key issue in producing a reliable estimate of the global burden of trachoma is the limited amount of reliable survey data from endemic regions... - Clearing the backlog: trichiasis surgeon retention and productivity in northern EthiopiaEsmael Habtamu
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS Negl Trop Dis 5:e1014. 2011..Despite an extensive integrated eye care worker training programme (IECW) and robust support for TT surgical services, productivity has not reached targets. We investigated why surgeon productivity was below target... - Trachoma: an overviewMatthew J Burton
International Centre for Eye Health, Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Br Med Bull 84:99-116. 2007..Where this programme has been fully implemented, it has met with some success. However, there are significant gaps in the evidence base and optimal management remains uncertain... - Chlamydial positivity of nasal discharge at baseline is associated with ocular chlamydial positivity 2 months following azithromycin treatmentEmily West Gower
Dana Center for Preventive Ophthalmology, 116 Wilmer Building, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
Invest Ophthalmol Vis Sci 47:4767-71. 2006..Routes of transmission remain unclear. In this study, the relationship between Chlamydia trachomatis Amplicor-positive nasal discharge and Amplicor-positive ocular swabs was investigated (Amplicor; Roche, Indianapolis, IN)...