Kar Wah Leung

Summary

Country: UK

Publications

  1. ncbi Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
    K W Leung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Neuropharmacology 52:827-35. 2007
  2. ncbi Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Hong Kong
    FEBS Lett 581:2423-8. 2007
  3. ncbi Pharmacology of ginsenosides: a literature review
    Kar Wah Leung
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, PR China
    Chin Med 5:20. 2010
  4. ncbi Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Hong Kong, China
    Br J Pharmacol 156:626-37. 2009
  5. ncbi Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Hong Kong
    FEBS Lett 580:3211-6. 2006
  6. ncbi Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Biol Chem 281:36280-8. 2006
  7. ncbi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008

Collaborators

Detail Information

Publications7

  1. ncbi Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity
    K W Leung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Neuropharmacology 52:827-35. 2007
    ..Thus, Rg1 and its related compounds may be developed as protective agents against neurodegenerative diseases induced by mitochondrial toxins...
  2. ncbi Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Hong Kong
    FEBS Lett 581:2423-8. 2007
    ....
  3. ncbi Pharmacology of ginsenosides: a literature review
    Kar Wah Leung
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, PR China
    Chin Med 5:20. 2010
    ..The multiple biological actions make ginsenosides as important resources for developing new modalities. Yet, low bioavailability of ginsenoside is one of the major hurdles needs to be overcome to advance its use in clinical settings...
  4. ncbi Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Hong Kong, China
    Br J Pharmacol 156:626-37. 2009
    ..Effects on expression of GR and ER isoforms in HUVECs were determined using reverse transcriptase-/real-time PCR and immunocytochemistry. Phosphorylation of endothelial NO synthase (eNOS) was assessed by Western blotting...
  5. ncbi Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Hong Kong
    FEBS Lett 580:3211-6. 2006
    ..This study revealed that Rg1 can indeed serve as an agonist ligand for GR and the activated GR can induce rapid NO production from eNOS via the non-transcriptional PI3K/Akt pathway...
  6. ncbi Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells
    Kar Wah Leung
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Biol Chem 281:36280-8. 2006
    ..In addition, the GR antagonist RU486 was able to inhibit Rg1-induced PI3K/Akt and beta-catenin activation. These findings provide new insights into the mechanism responsible for Rg1 functions...
  7. ncbi Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants
    Yuan He
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 49:1447-58. 2008
    ..The authors provide evidence that mitochondrial dysfunction is a possible mechanism for the loss of trabecular meshwork (TM) cells in persons with POAG...