Research Topics
| T WykesSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
Effects on the brain of a psychological treatment: cognitive remediation therapy: functional magnetic resonance imaging in schizophreniaTil Wykes
Department of Psychiatry, Institute of Psychiatry, London, UK
Br J Psychiatry 181:144-52. 2002..The results of one randomised control trial testing a psychological rehabilitation programme aimed at information processing strategies showed improvements in cognition post-treatment...
Cognitive remediation therapy in schizophrenia: randomised controlled trialTil Wykes
Department of Psychology, Kings College London, Institute of Psychiatry, London, UK
Br J Psychiatry 190:421-7. 2007..Cognitive difficulties are prevalent in people with a diagnosis of schizophrenia and are associated with poor long-term functioning...
More than just a place to talk: young people's experiences of group psychological therapy as an early intervention for auditory hallucinationsElizabeth Newton
University College, London, UK
Psychol Psychother 80:127-49. 2007..The aim of the current study is to explore the experience of group-CBT amongst a group of young people experiencing distressing auditory hallucinations...
Cognitive remediation therapy (CRT) for young early onset patients with schizophrenia: an exploratory randomized controlled trialTil Wykes
Institute of Psychiatry, Kings College London, De Crespigny Park, London, SE5 8AF, UK
Schizophr Res 94:221-30. 2007..The objective of this study is to evaluate the efficacy of CRT in alleviating cognitive deficits compared to treatment as usual and explore the mediating and moderating effects of cognitive improvement...
Cognitive remediation for schizophrenia: it is even more complicatedTil Wykes
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Curr Opin Psychiatry 22:161-7. 2009..This review summarizes findings of induced cognitive change in schizophrenia, with reference to the remediation method, the presence of accompanying treatment(s), how cognitive change generalizes and its value...
Are the effects of cognitive remediation therapy (CRT) durable? Results from an exploratory trial in schizophreniaTil Wykes
Department of Psychology, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
Schizophr Res 61:163-74. 2003..At the end of treatment, CRT conferred a benefit to people with schizophrenia in cognition and self-esteem [Schizophr. Bull. 25 (1999) 291]. This study investigates these outcomes 6 months after the therapies were withdrawn...
Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigorTil Wykes
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Schizophr Bull 34:523-37. 2008..But recent advances have widened the CBTp targets to other symptoms and have different methods of provision, eg, in groups...
What are the effects of group cognitive behaviour therapy for voices? A randomised control trialTil Wykes
Department of Psychology, Institute of Psychiatry, Kings College London, United Kingdom
Schizophr Res 77:201-10. 2005..This study tested whether a group based on cognitive behavioural principles could produce beneficial effects on hallucinations...
Is it time to develop a new cognitive therapy for psychosis--cognitive remediation therapy (CRT)?T Wykes
Kings College London, UK
Clin Psychol Rev 21:1227-56. 2001..The current review tries to put this evidence into context and sets out a programme of research, which is essential in this area if future progress is to be made...
The prevalence and stability of an executive processing deficit, response inhibition, in people with chronic schizophreniaT Wykes
Department of Psychology, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
Schizophr Res 46:241-53. 2000..The level of response inhibition difficulties (about one-third) was identical in the new sample of patients, which suggests that response inhibition is not dependent on clinical history...
Continuity of care in mental health: understanding and measuring a complex phenomenonT Burns
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Psychol Med 39:313-23. 2009..We aimed to operationalize a multi-axial model of continuity of care and to use factor analysis to determine its validity for severe mental illness...
Group treatment of auditory hallucinations. Exploratory study of effectivenessT Wykes
Department of Psychology, Institute of Psychiatry, London
Br J Psychiatry 175:180-5. 1999..Cognitive-behavioural therapy has been shown to be effective in reducing psychotic symptoms, but few patients have access to these services. Group cognitive treatment may provide a less costly service with similar benefits...
Can we harness computerised cognitive bias modification to treat anxiety in schizophrenia? A first step highlighting the role of mental imageryCraig Steel
Department of Psychology, University of Reading, Early Gate, Reading RG66AL, UK
Psychiatry Res 178:451-5. 2010..We discuss the implications for harnessing computerised CBM therapy developments for co-morbid anxiety in schizophrenia...
Effects of depressed mood on objective and subjective measures of attentionLydia Farrin
Gulf War Illnesses Research Unit, Guy's, King's, and St. Thomas' School of Medicine, London, UK
J Neuropsychiatry Clin Neurosci 15:98-104. 2003..Nonclinical depressed subjects may respond "catastrophically" to errors, heightening the subjective sense of failure and contributing to the strong relationship between subjectively reported cognitive failures and depression...
The use of outcome measures to evaluate the efficacy and tolerability of antipsychotic medication: a comparison of Thorn graduate and CPN practiceR Gray
Health Services Research Department, Institute of Psychiatry, De Crespigny Park, London, UK
J Psychiatr Ment Health Nurs 8:191-6. 2001..A programme of targeted training may be a more realistic and efficient method of enhancing medication management practices in large numbers of CPNs compared to the more expensive and time-consuming Thorn programme...
Impaired verbal self-monitoring in individuals at high risk of psychosisL C Johns
Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
Psychol Med 40:1433-42. 2010..We used a paradigm that engages verbal self-monitoring (VSM) to examine whether this process is impaired in people experiencing prodromal symptoms, who have a very high risk of developing psychosis...
The self or the voice? Relative contributions of self-esteem and voice appraisal in persistent auditory hallucinationsDominic Fannon
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, Kings College London, Denmark Hill, London, UK
Schizophr Res 112:174-80. 2009..It was hypothesized that low self-esteem is prominent in, and contributes to, depression in voice hearers...
Executive functioning in schizophrenia and the relationship with symptom profile and chronicityKathryn E Greenwood
Department of Psychology, Institute of Psychiatry, London, United Kingdom
J Int Neuropsychol Soc 14:782-92. 2008..The executive profile, therefore, is related to symptom type rather than chronicity...
Does age matter? Effects of cognitive rehabilitation across the age spanTil Wykes
King s College, Institute of Psychiatry London, UK
Schizophr Res 113:252-8. 2009..Cognitive remediation (CR) therapy in its various disguises can be helpful for people with schizophrenia but it is not clear if patient characteristics are likely to interfere with its effectiveness...
Cognitive remediation therapy in schizophrenia: cost-effectiveness analysisAnita Patel
Centre for the Economics of Mental Health, Health Service and Population Research Department, Box 24, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
Schizophr Res 120:217-24. 2010..There is a lack of evidence on the cost-effectiveness of cognitive remediation therapy (CRT)...
A comparison of participant information elicited by service user and non-service user researchersDiana Rose
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
Psychiatr Serv 62:210-3. 2011..The study examined whether data collected by researchers who were service users differed from data collected by non-service user researchers in a study that measured perceived coercion...
Cognitive predictors of social functioning improvements following cognitive remediation for schizophreniaClare Reeder
Department of Psychology, Institute of Psychiatry, Kings College, De Crespigny Park, London SE5 8AF, UK
Schizophr Bull 32:S123-31. 2006..Improvement in the ability to generate new schemas has a beneficial impact on social functioning...
Patients' perspectives on electroconvulsive therapy: systematic reviewDiana Rose
Service User Research Enterprise, PO34, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
BMJ 326:1363. 2003..To ascertain patients' views on the benefits of and possible memory loss from electroconvulsive therapy...
Schizophrenia patients with cognitive deficits: factors associated with costsAnita Patel
Centre for the Economics of Mental Health, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Schizophr Bull 32:776-85. 2006..Further investigation in larger samples is needed to confirm this finding and to explore its generalizability to those with less severe deficits...
Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapyKathryn E Greenwood
Department of Psychology, Institute of Psychiatry, London
Schizophr Bull 31:910-21. 2005..Both cognitive processes and negative symptoms should be targeted in cognitive remediation to effect the greatest change in community functions...
Which executive skills should we target to affect social functioning and symptom change? A study of a cognitive remediation therapy programClare Reeder
Department of Psychology, Institute of Psychiatry, London, UK
Schizophr Bull 30:87-100. 2004..Regardless of treatment type, increased response inhibition speed was associated with reduced negative symptoms. Stimulus-driven responding and response inhibition speed may therefore make useful targets for intervention...
Different components of metacognition and their relationship to psychotic-like experiencesClare Reeder
Institute of Psychiatry, King s College London, UK
Behav Cogn Psychother 38:49-57. 2010..However, studies offering supporting evidence have failed to distinguish between metacognitive beliefs about the consequences of having certain thoughts, and metacognitive beliefs about one's own cognitive skills...
Effect of a medication management training package for nurses on clinical outcomes for patients with schizophrenia: cluster randomised controlled trialRichard Gray
PO 30, Health Services Research Department, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
Br J Psychiatry 185:157-62. 2004..Non-compliance attenuates the efficacy of treatments for physical and mental disorders...
The effect of medication management training on community mental health nurse's clinical skillsRichard Gray
Health Services Research Department, Institute of Psychiatry, De Crespigny Park, SE5 8AF, London, UK
Int J Nurs Stud 40:163-9. 2003..Conclusions. In this uncontrolled study training improved the medication management skills of CMHNs...
A model for developing outcome measures from the perspectives of mental health service usersDiana Rose
Service User Research Enterprise, Institute of Psychiatry, King s College London, UK
Int Rev Psychiatry 23:41-6. 2011..The final measure is subject to psychometric testing both to ensure it is robust and to explore similarities and differences with conventionally derived measures...
What are we changing with neurocognitive rehabilitation? Illustrations from two single cases of changes in neuropsychological performance and brain systems as measured by SPECTT Wykes
Department of Pyschology, Institute of Psychiatry, London, UK
Schizophr Res 34:77-86. 1998..Further investigation of whether it is possible to change idiosyncratic strategy use is needed if we are to develop the efficacy of this remediation technique...
From compliance to concordance: a review of the literature on interventions to enhance compliance with antipsychotic medicationR Gray
MRC Fellow in Health Services Research, Health Services Research Department, Institute of Psychiatry, De Crespigny Park, London, UK
J Psychiatr Ment Health Nurs 9:277-84. 2002..However, interventions, such as compliance therapy, based on cognitive-behavioural techniques appear to be effective in enhancing compliance and preventing relapse...
Utilisation and costs of community mental health services. PRiSM Psychosis Study. 5P McCrone
Section of Community Psychiatry PRiSM, Institute of Psychiatry, London
Br J Psychiatry 173:391-8. 1998..The costs and the effectiveness of mental health services need to be evaluated if provision is to be efficient. Service use and costs are described for two geographical areas in south London...
Developing a user-generated measure of continuity of care: brief reportD Rose
Institute of Psychiatry, King s College London, London, UK
Acta Psychiatr Scand 119:320-4. 2009..In contrast to others, this measure has been generated from the perspectives of service users. As continuity of care is a concern particularly for those with severe mental illness, we have confined our work to this population group...
Modification of performance on the Span of Apprehension Task in a group of young people with early onset psychosisTorill Ueland
Sogn Centre for Child and Adolescent Psychiatry, Oslo, Norway
Scand J Psychol 45:55-60. 2004..The study suggests that SPAN performance can be improved in young people with early onset psychosis using relatively simple interventions and that performance gains are relatively durable...
Are all psychological treatments for psychosis equal? The need for CBT in the treatment of psychosis and not for psychodynamic psychotherapyNicholas Tarrier
Academic Division of Clinical Psychology, School of Psychiatry and Behavioural Science, University of Manchester, Wythenshawe Hospital, UK
Psychol Psychother 75:365-74; discussion 375-9. 2002..We consider the research and clinical priorities to be the further developments of CBT and family intervention methods, which could have significant benefits for sufferers of schizophrenia and their carers...
Neuropsychological task performance before and after cognitive remediation in anorexia nervosa: a pilot case-seriesKate Tchanturia
Psychol Med 38:1371-3. 2008
Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia InitiativeCameron S Carter
Department of Psychiatry, University of California, Davis, CA 95817, USA
Biol Psychiatry 64:4-10. 2008..The articles in this special section report on the results of the first conference, which used a criterion-based consensus-building process to develop a set of cognitive constructs to be targeted for translation efforts...
Is there evidence that cognitive behaviour therapy is an effective treatment for schizophrenia? A cautious or cautionary tale?Nicholas Tarrier
Academic Division of Clinical Psychology University of Manchester, Education and Research Building 2nd Floor, Wythenshawe Hospital, Manchester M23 9LT, UK
Behav Res Ther 42:1377-401. 2004..We conclude cautiously that overall there is good evidence for the efficacy and effectiveness of CBTp in the treatment of schizophrenia...
Early psychological intervention for auditory hallucinations: an exploratory study of young people's voices groupsElizabeth Newton
Early Intervention Service and Department of Psychology, Mental Health Services, Wulstan Unit, Newtown Hospital, Newtown Road, Worcester WR5 1JG, UK
J Nerv Ment Dis 193:58-61. 2005..Significant reductions in auditory hallucinations occurred over the total treatment phase, but not over the waiting period. Further investigations in the form of randomized controlled trials are warranted...
Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshopAlan S Bellack
University of Maryland School of Medicine, 737 West Lombard Street, Suite 551, Baltimore, MD 21201, USA
Schizophr Bull 33:805-22. 2007..quot; This criterion is problematic because different observers and constituencies often have different opinions about what types of change are clinically important and how much change is significant...
Cognitive remediation and vocational rehabilitationSusan R McGurk
Dartmouth Psychiatric Research Center, Dartmouth Medical School, Concord, NH 03301, USA
Psychiatr Rehabil J 31:350-9. 2008....
