Research Topics
| K RubiaSummaryAffiliation: King's College London Country: UK Publications
| Collaborators
|
Detail Information
Publications
The dynamic approach to neurodevelopmental psychiatric disorders: use of fMRI combined with neuropsychology to elucidate the dynamics of psychiatric disorders, exemplified in ADHD and schizophreniaKatya Rubia
Department of Child and Adolescent Psychiatry Unit, Institute of Psychiatry Kings College, De Crespigny Park, London SE 8AF, UK
Behav Brain Res 130:47-56. 2002..Comparisons between patient groups will be essential to address the specificity of neurocognitive mechanisms corresponding to specific neurodevelopmental psychiatric disorders...
Linear age-correlated functional development of right inferior fronto-striato-cerebellar networks during response inhibition and anterior cingulate during error-related processesKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, London SE5 8AF, United Kingdom
Hum Brain Mapp 28:1163-77. 2007..This study shows developmental specialization of the integrated function of right inferior prefrontal cortex, basal ganglia, thalamus, and cerebellum for inhibitory control and of anterior cingulate gyrus for error-related processes...
"Cool" inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus "hot" ventromedial orbitofrontal-limbic dysfunction in conduct disorder: a reviewKatya Rubia
Department of Child Psychiatry Medical Research Council Center for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 69:e69-87. 2011..There is, hence, evidence for dissociated underlying pathophysiologies for these two disorders that may have implications for future anatomy-based differential diagnosis and prevention and intervention...
Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHDKatya Rubia
Department of Psychiatry, Institute of Psychiatry, 16 De Crespigny Park, London SE5 8AF, UK
Am J Psychiatry 162:1067-75. 2005....
Progressive increase of frontostriatal brain activation from childhood to adulthood during event-related tasks of cognitive controlKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
Hum Brain Mapp 27:973-93. 2006..The findings suggest progressive maturation of task-specific frontostriatal and frontocortical networks for cognitive control functions in the transition from childhood to mid-adulthood...
Performance of children with attention deficit hyperactivity disorder (ADHD) on a test battery of impulsivenessKatya Rubia
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Kings College, London, UK
Child Neuropsychol 13:276-304. 2007..The task battery as a whole showed 76% correct discrimination of cases and controls...
Temporal lobe dysfunction in medication-naïve boys with attention-deficit/hyperactivity disorder during attention allocation and its relation to response variabilityKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Biol Psychiatry 62:999-1006. 2007..Furthermore, we explore the relationship between the neural substrates of attention allocation and response variability, typically increased in patients...
Neuro-anatomic evidence for the maturational delay hypothesis of ADHDKatya Rubia
Department of Child Psychiatry/Medical Research Council Social, Genetic, and Developmental Psychiatry Research Center (SGDP, Institute of Psychiatry, 16 De Crespigny Park, SG DP PO46, London SE5 8AF, United Kingdom
Proc Natl Acad Sci U S A 104:19663-4. 2007
Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory controlJames Woolley
Child and Adolescent Psychiatry PO 46, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK
Br J Psychiatry 192:25-31. 2008..Obsessive-compulsive disorder (OCD) may be related to a dysfunction in frontostriatal pathways mediating inhibitory control. However, no functional magnetic resonance imaging (fMRI) study has tested this in children...
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorderKatya Rubia
Department of Child Psychiatry MRC Center for Social, Genetic, and Developmental Psychiatry, Institute of Psychiatry, King s College, London SE5 8AF, UK
Am J Psychiatry 165:889-97. 2008....
Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attentionKatya Rubia
Department of Child Psychiatry MRC Center for Social, Genetic and Developmental Psychiatry SGDP, Institute of Psychiatry, King s College, 16 De Crespigny Park, London, SE5 8AF, UK
Am J Psychiatry 166:83-94. 2009....
Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocationKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
J Child Psychol Psychiatry 50:669-78. 2009..This study investigates differences and commonalities in functional neural networks mediating interference inhibition and attention allocation between medication-naïve children and adolescents with pure CD and those with pure ADHD...
The neurobiology of Meditation and its clinical effectiveness in psychiatric disordersKatya Rubia
Institute of Psychiatry, Department of Child and Adolescent Psychiatry, King s College University London, UK
Biol Psychol 82:1-11. 2009....
Impulsiveness as a timing disturbance: neurocognitive abnormalities in attention-deficit hyperactivity disorder during temporal processes and normalization with methylphenidateKatya Rubia
Department of Child Psychiatry MRC Center for Social, Genetic and Developmental Psychiatry SGDP, Institute of Psychiatry, 16 De Crespigny Park, London, UK
Philos Trans R Soc Lond B Biol Sci 364:1919-31. 2009....
Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance taskKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
Neuropharmacology 57:640-52. 2009....
Disorder-specific dysfunction in right inferior prefrontal cortex during two inhibition tasks in boys with attention-deficit hyperactivity disorder compared to boys with obsessive-compulsive disorderKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Hum Brain Mapp 31:287-99. 2010....
Effects of age and sex on developmental neural networks of visual-spatial attention allocationKatya Rubia
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, UK
Neuroimage 51:817-27. 2010....
Disorder-specific inferior prefrontal hypofunction in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure conduct disorder during cognitive flexibilityKatya Rubia
Department of Child Psychiatry, MRC Center for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College, London, United Kingdom
Hum Brain Mapp 31:1823-33. 2010..This study investigates disorder-specific functional abnormalities during cognitive flexibility between medication-naïve children and adolescents with noncomorbid CD and those with noncomorbid ADHD compared to healthy controls...
Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRIKatya Rubia
Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
Psychopharmacology (Berl) 179:791-803. 2005....
An fMRI study of reduced left prefrontal activation in schizophrenia during normal inhibitory functionK Rubia
Department of Child Psychiatry, Psychological Medicine, and Neurology, Institute of Psychiatry, King s College, De Crespigny Park, SE5 8AF, London, UK
Schizophr Res 52:47-55. 2001..Despite good task performance, patients with schizophrenia thus showed abnormal neural network patterns of reduced left prefrontal activation and increased subcortical activation when challenged with motor response inhibition...
Functional frontalisation with age: mapping neurodevelopmental trajectories with fMRIK Rubia
Institute of Psychiatry King s College, University of London, UK
Neurosci Biobehav Rev 24:13-9. 2000..A significant age effect was found for the prefrontal activation in both task, confirming the hypothesis of a dysmaturational pathogenesis for the hypofrontality in ADHD...
Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRIK Rubia
Medical Research Council Child and Adolescent Psychiatry Unit, Kings College, London, U K
Am J Psychiatry 156:891-6. 1999....
Mapping motor inhibition: conjunctive brain activations across different versions of go/no-go and stop tasksK Rubia
Institute of Psychiatry, King s College, London, UK
Neuroimage 13:250-61. 2001....
Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detectionKatya Rubia
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Neuroimage 20:351-8. 2003..Failure to inhibit was associated with activation in mesial frontopolar and bilateral inferior parietal cortices, presumably reflecting an attention network for error detection...
Motor timing deficits in community and clinical boys with hyperactive behavior: the effect of methylphenidate on motor timingKatya Rubia
Institute of Psychiatry, King s College London, London, United Kingdom
J Abnorm Child Psychol 31:301-13. 2003....
The neural correlates of cognitive time management: a reviewKatya Rubia
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, United Kingdom
Acta Neurobiol Exp (Wars) 64:329-40. 2004..The review shows that the same brain regions are involved in both motor timing and time estimation, suggesting that both functions are probably inseparable and mediated by common neural networks...
Neuropsychological analyses of impulsiveness in childhood hyperactivityK Rubia
MRC Child and Adolescent Psychiatry Unit, Institute of Psychiatry, King s College, London, UK
Br J Psychiatry 179:138-43. 2001..Neuropsychological analyses of impulsiveness are needed to refine assessment of attention-deficit hyperactivity disorder (ADHD)...
Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorderAnna B Smith
Department of Child Psychiatry, Institute of Psychiatry, King's College, London, SE5 8AF, UK
Am J Psychiatry 163:1044-51. 2006..Furthermore, functional abnormalities are task-specific and extend from frontostriatal to parietal and temporal cortices...
Synchronization, anticipation, and consistency in motor timing of children with dimensionally defined attention deficit hyperactivity behaviourK Rubia
MRC Child Psychiatry Unit, Institute of Psychiatry, Maudsley Hospital, London
Percept Mot Skills 89:1237-58. 1999..Hyperactive children were more inconsistent than controls in maintaining a freely chosen tapping rhythm, in synchronizing and in anticipating their motor response to external visual stimulation...
Sex-dependent age modulation of frontostriatal and temporo-parietal activation during cognitive controlAnastasia Christakou
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, Box P046, De Crespigny Park SE5 8AF, UK
Neuroimage 48:223-36. 2009..Gender differences in frontal and parietal recruitment may thus be related to gender differences in the neurofunctional maturation of these brain regions...
Inhibitory dysfunction in hyperactive boysK Rubia
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Maudsley Hospital, London, UK
Behav Brain Res 94:25-32. 1998..Furthermore, the go-process of the hyperactives was more variable and erratic in both tasks. Thus, the results strengthen the effectiveness of stop tasks in distinguishing hyperactive from normal children...
Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attributionT A Russell
Institute of Psychiatry, King s College, London, UK
Am J Psychiatry 157:2040-2. 2000..The authors used functional magnetic resonance imaging (MRI) to investigate the hypothesis that patients with schizophrenia have a dysfunction in brain regions responsible for mental state attribution...
Neural correlates of executive function in autistic spectrum disordersNicole Schmitz
Department of Psychological Medicine, Section of Brain Maturation, Institute of Psychiatry, King College London, UK
Biol Psychiatry 59:7-16. 2006..However, to date, no functional imaging study on ASD has investigated inhibition and cognitive flexibility and no one has related EF brain activation to brain structure...
Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorderRachel V Gow
Department of Child and Adolescent Psychiatry, PO Box 85, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE58AF, UK
Prostaglandins Leukot Essent Fatty Acids 80:151-6. 2009....
Disorder-specific dysfunctions in patients with attention-deficit/hyperactivity disorder compared to patients with obsessive-compulsive disorder during interference inhibition and attention allocationKatya Rubia
Department of Child Psychiatry, Institute of Psychiatry, King s College London, London, UK
Hum Brain Mapp 32:601-11. 2011..The aim of this study was to investigate disorder-specific abnormalities in neural networks mediating interference inhibition and selective attention...
Right ventromedial and dorsolateral prefrontal cortices mediate adaptive decisions under ambiguity by integrating choice utility and outcome evaluationAnastasia Christakou
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, United Kingdom
J Neurosci 29:11020-8. 2009..These findings provide functional evidence of the underlying processes by which these prefrontal subregions drive adaptive choice in the task, namely through contingency-sensitive outcome evaluation...
A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorderLisa A Page
King s College London, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, Room 3 14, Weston Education Centre, 10 Cutcombe Road, London, SE5 9RJ, UK
Psychiatry Res 174:202-9. 2009..OCD is associated with task-relevant fronto-striatal dysfunction during motor inhibition and cognitive switching. In addition, parieto-temporal dysfunction was observed during tasks with a higher attentional load...
Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood Attention-Deficit Hyperactivity Disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switchingAna Cubillo
Department of Child Psychiatry, Institute of Psychiatry, King s College, London SE5 8AF, UK
J Psychiatr Res 44:629-39. 2010..This suggests that neuro-functional abnormalities in ADHD patients are likely to continue between childhood and early adulthood...
Structural and functional brain imaging in adult attention-deficit/hyperactivity disorderAna Cubillo
Department of Child Psychiatry SGDP, P046, Institute of Psychiatry, 16 De Crespigny Park, London, SE5 8AF, UK
Expert Rev Neurother 10:603-20. 2010....
Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controlsRozmin Halari
Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 50:307-16. 2009..This study investigated whether medication-naïve adolescents with MDD show abnormal brain activation of fronto-striatal and fronto-cingulate networks when performing tasks of attentional and cognitive control...
A right hemispheric frontocerebellar network for time discrimination of several hundreds of millisecondsAnna Smith
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
Neuroimage 20:344-50. 2003..We conclude that right DLPFC, rather than having a purely working memory function, might be more centrally involved in time perception than previously thought...
5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletionMelissa Lamar
Department of Psychology, Institute of Psychiatry, King s College London, London, UK
Neurobiol Aging 30:1135-46. 2009..Maintaining successful Simon performance during ATD is achieved by increasing cerebellar and parietal contributions to compensate for decreased fronto-cingulo-striatal involvement...
The neural basis of response inhibition and attention allocation as mediated by gestational ageEmma J Lawrence
Department of Psychological Medicine, Institute of Psychiatry, King s College London, United Kingdom
Hum Brain Mapp 30:1038-50. 2009....
Evidence for a pure time perception deficit in children with ADHDAnna Smith
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 43:529-42. 2002..The aim of this study was to explore further the abilities of hyperactive children in skills of time estimation, using a range of time perception tasks in different temporal domains...
Altered functional neuroanatomy of response inhibition in adolescent males who were born very pretermChiara Nosarti
Division of Psychological Medicine, Institute of Psychiatry, London, UK
Dev Med Child Neurol 48:265-71. 2006....
Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibitionStefan J Borgwardt
Section of Neuroimaging, Institute of Psychiatry, King s College London, United Kingdom
Biol Psychiatry 64:966-73. 2008..This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task...
Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discriminationAnna B Smith
Centre for Social Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College, London, UK
J Child Psychol Psychiatry 49:977-85. 2008..We investigated the neuro-anatomical substrates mediating fine temporal discrimination in adolescents with ADHD compared with controls, using functional magnetic resonance imaging (fMRI)...
Neural correlates of switching set as measured in fast, event-related functional magnetic resonance imagingAnna B Smith
Department of Child Psychiatry, Institute of Psychiatry, King's College London, London, United Kingdom
Hum Brain Mapp 21:247-56. 2004..We conclude that left DLPFC activation is involved directly in cognitive switching, in conjunction with parietal and temporal brain regions. Pre- and postcentral gyrus activation may be related to motor components of switching set...
Timing of covert articulation: an fMRI studyS S Shergill
CSI Lab, Institute of Psychiatry, Kings College London, UK
Neuropsychologia 44:2573-7. 2006..Modality specific activation in the right temporal cortex may have reflected the involvement of this region in auditory-verbal processing...
Heterozygous PAX6 mutation, adult brain structure and fronto-striato-thalamic function in a human familyZoë Ellison-Wright
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Eur J Neurosci 19:1505-12. 2004..Highly conserved homeobox genes may be critical for normal ontogenesis of large-scale neurocognitive networks supporting phylogenetically advanced mental functions...
Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging studySamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Biol Psychiatry 65:550-5. 2009..However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined...
Conduct problems in adolescence: three domains of inhibition and effect of genderCatherine M Herba
Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Children s Hospital, 3000 CB Rotterdam, The Netherlands
Dev Neuropsychol 30:659-95. 2006....
Neural correlates of reward in autismNicole Schmitz
Amsterdam Medical Centre, Department of Psychiatry, Amsterdam, The Netherlands
Br J Psychiatry 192:19-24. 2008..However, no reported in vivo brain imaging studies have investigated reward mechanisms in autistic-spectrum disorder...
Frontal lobe structure and executive function in migraine patientsNicole Schmitz
Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
Neurosci Lett 440:92-6. 2008..Frontal and parietal lobe abnormalities in migraineurs could be an underlying cause of significantly slower response time during cognitive set-shifting...
Towards an understanding of unique and shared pathways in the psychopathophysiology of ADHDTobias Banaschewski
Child and Adolescent Psychiatry, University of Gottingen, Von Siebold Str 5, D 37075 Gottingen, Germany
Dev Sci 8:132-40. 2005....
