J R Morris

Summary

Affiliation: King's College London
Country: UK

Publications

  1. ncbi Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility
    Joanna R Morris
    Department of Medical and Molecular Genetics, Kings College London School of Medicine at Guy s, Kings and St Thomas Hospitals, Guy s Hospital, 8th Floor Guy s Tower, St Thomas Street, London SE1 9RT, UK
    Hum Mol Genet 15:599-606. 2006
  2. ncbi Biallelic mutation of MSH2 in primary human cells is associated with sensitivity to irradiation and altered RAD51 foci kinetics
    J Barwell
    Department of Genetics, St George s Medical School, University of London, Cranmer Terrace, London, UK
    J Med Genet 44:516-20. 2007
  3. ncbi The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
    Joanna R Morris
    Department of Medical and Molecular Genetics, King s College London, Guy s Medical School Campus, London SE1 9RT, UK
    Nature 462:886-90. 2009
  4. ncbi SUMO in the mammalian response to DNA damage
    Joanna R Morris
    King s College London, Guy s Hospital Campus, St Thomas Street, London SE1 9RT, UK
    Biochem Soc Trans 38:92-7. 2010
  5. ncbi More modifiers move on DNA damage
    Joanna R Morris
    Department of Medical and Molecular Genetics, King s College London, Guy s Medical School Campus, London, United Kingdom
    Cancer Res 70:3861-3. 2010
  6. ncbi Identification of residues required for the interaction of BARD1 with BRCA1
    Joanna R Morris
    Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, Guy s, Kings and St Thomas Schools of Medicine, London SE1 9RT, United Kingdom
    J Biol Chem 277:9382-6. 2002
  7. ncbi BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair
    Joanna R Morris
    Department of Medical and Molecular Genetics, Division of Genetics and Development, Guy s Kings and St Thomas School of Medicine, King s College London, Guy s Hospital, London SE1 9RT, UK
    Hum Mol Genet 13:807-17. 2004
  8. ncbi Structural evolution of the BRCA1 genomic region in primates
    Hong Jin
    Division of Medical and Molecular Genetics, GKT Medical School, King s College, London SE1 9RT, UK
    Genomics 84:1071-82. 2004
  9. ncbi Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility
    Julian Barwell
    Clinical Genetics, St George s University of London, United Kingdom
    Int J Cancer 121:1631-6. 2007

Collaborators

Detail Information

Publications9

  1. ncbi Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility
    Joanna R Morris
    Department of Medical and Molecular Genetics, Kings College London School of Medicine at Guy s, Kings and St Thomas Hospitals, Guy s Hospital, 8th Floor Guy s Tower, St Thomas Street, London SE1 9RT, UK
    Hum Mol Genet 15:599-606. 2006
    ....
  2. ncbi Biallelic mutation of MSH2 in primary human cells is associated with sensitivity to irradiation and altered RAD51 foci kinetics
    J Barwell
    Department of Genetics, St George s Medical School, University of London, Cranmer Terrace, London, UK
    J Med Genet 44:516-20. 2007
    ..Previous studies have investigated cells established from immortalised human colorectal tumour lines or cells from animal models...
  3. ncbi The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
    Joanna R Morris
    Department of Medical and Molecular Genetics, King s College London, Guy s Medical School Campus, London SE1 9RT, UK
    Nature 462:886-90. 2009
    ..These data demonstrate that the SUMOylation pathway plays a significant role in mammalian DNA damage response...
  4. ncbi SUMO in the mammalian response to DNA damage
    Joanna R Morris
    King s College London, Guy s Hospital Campus, St Thomas Street, London SE1 9RT, UK
    Biochem Soc Trans 38:92-7. 2010
    ..The present review examines roles described for the SUMO pathway in the way mammalian cells respond to genotoxic stress...
  5. ncbi More modifiers move on DNA damage
    Joanna R Morris
    Department of Medical and Molecular Genetics, King s College London, Guy s Medical School Campus, London, United Kingdom
    Cancer Res 70:3861-3. 2010
    ....
  6. ncbi Identification of residues required for the interaction of BARD1 with BRCA1
    Joanna R Morris
    Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, Guy s, Kings and St Thomas Schools of Medicine, London SE1 9RT, United Kingdom
    J Biol Chem 277:9382-6. 2002
    ....
  7. ncbi BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair
    Joanna R Morris
    Department of Medical and Molecular Genetics, Division of Genetics and Development, Guy s Kings and St Thomas School of Medicine, King s College London, Guy s Hospital, London SE1 9RT, UK
    Hum Mol Genet 13:807-17. 2004
    ..Together these data demonstrate that BRCA1 directed ligation of ubiquitin occurs during S-phase and in response to replication stress and DNA damage and is therefore likely to be a significant aspect of BRCA1 cellular activity...
  8. ncbi Structural evolution of the BRCA1 genomic region in primates
    Hong Jin
    Division of Medical and Molecular Genetics, GKT Medical School, King s College, London SE1 9RT, UK
    Genomics 84:1071-82. 2004
    ....
  9. ncbi Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility
    Julian Barwell
    Clinical Genetics, St George s University of London, United Kingdom
    Int J Cancer 121:1631-6. 2007
    ..Our results show a demonstrable impairment in irradiation induced DNA repair in women with heterozygous germline BRCA1 and BRCA2 mutations prior to being diagnosed with breast cancer...