Research Topics
| Y KhalafSummaryAffiliation: King's College London Country: UK Publications
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Detail Information
Publications
A multi-centre randomised controlled study of pre-IVF outpatient hysteroscopy in women with recurrent IVF implantation failure: Trial of Outpatient Hysteroscopy - [TROPHY] in IVFTarek El-Toukhy
Assisted Conception Unit, Guy s and St Thomas Foundation Trust, London, SE1 9RT, UK
Reprod Health 6:20. 2009..A favourable ethical opinion has been obtained (REC reference: 09/H0804/32). TRAIL REGISTRATION: The trial has been assigned the following ISRCTN number: ISRCTN35859078...- Selective single blastocyst transfer reduces the multiple pregnancy rate and increases pregnancy rates: a pre- and postintervention studyY Khalaf
Assisted Conception Unit, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
BJOG 115:385-90. 2008..To examine the clinical pregnancy rate (CPR) and multiple pregnancy rate (MPR) in a large in vitro fertilisation (IVF) programme before and after the introduction of single blastocyst transfer (SBT) strategy in a selected group of women... - The effect of small intramural uterine fibroids on the cumulative outcome of assisted conceptionY Khalaf
Assisted Conception Unit, Guy s and St Thomas Hospital NHS Foundation Trust, Department of Women s Health, King s College London, UK
Hum Reprod 21:2640-4. 2006..This study aimed to evaluate the effect of small intramural fibroids on the cumulative pregnancy, ongoing pregnancy, live birth and implantation rates after three IVF/ICSI attempts... - Reducing multiple pregnancies after assisted reproduction treatment: Québec says 'Yes, we can!'Yakoub Khalaf
Assisted Conception Unit and Centre for Pre implantation Genetic Diagnosis, London, UK
Reprod Biomed Online 23:407-10. 2011..The risks of twin pregnancies are real and borne by women and children, not their doctors. Doctors managing infertile couples are no longer entitled to take risks with the health of the next generation... - The search for a practice model to reduce miscarriage after assisted reproductionYakoub Khalaf
Assisted Conception Unit and Centre for Pre implantation Genetic Diagnosis, London, UK Kings Health Partners, Women s Services, Guy s and St Thomas NHS Foundation Trust, London, UK
Reprod Biomed Online 23:695-6. 2011..Retrospective analysis of large national databases is useful in identifying trends and generating hypothesis, but evaluation of these hypotheses in randomized trials remains necessary for objective validation... - A prospective controlled study of the effect of intramural uterine fibroids on the outcome of assisted conceptionR Hart
Guy's and St Thomas' Assisted Conception Unit, St Thomas' Hospital, London, UK
Hum Reprod 16:2411-7. 2001..46 (CI 0.24-0.88; P = 0.019). CONCLUSION: This study demonstrated that an intramural fibroid halves the chances of an ongoing pregnancy following assisted conception... - Delayed blastocyst development does not influence the outcome of frozen-thawed transfer cyclesT El-Toukhy
Assisted Conception Unit, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
BJOG 118:1551-6. 2011..23 [95% confidence interval (CI), 0.81-1.86, P?=?0.34]. Conclusion? The pregnancy potential of high-grade blastocysts frozen on day 5 and day 6 after in vitro fertilisation and replaced in programmed TBT cycles is comparable... - Pituitary suppression in ultrasound-monitored frozen embryo replacement cycles. A randomised studyT El-Toukhy
Assisted Conception Unit, Guy s and St Thomas Hospital NHS Trust, St Thomas School of Medicine, St Thomas Street, London SE1 9RT, UK
Hum Reprod 19:874-9. 2004..This study was designed to assess the value of using a gonadotrophin-releasing hormone (GnRH) agonist prior to exogenous steroid supplementation for endometrial preparation in frozen-thawed embryo replacement (FER) cycles... - Outcomes of ovarian stimulation in a two-day oocyte collection week with PGD cycles compared to a five-day oocyte collection week with conventional IVF/ICSI cyclesH Hamoda
Assisted Conception Unit, King s College Hospital, London, UK
Hum Fertil (Camb) 14:254-60. 2011..This can allow the provision of a more patient friendly service, increase the flexibility of satellite PGD services, and facilitate cycle programming with the genetics team providing PGD... - A systematic review and meta-analysis of acupuncture in in vitro fertilisationT El-Toukhy
Assisted Conception Unit, Guy s and St Thomas Hospital, London, UK
BJOG 115:1203-13. 2008..Numerous randomised studies have reported pregnancy outcome in women who received acupuncture during their in vitro fertilisation (IVF) treatment cycle... - A systematic review of the effect of oral antioxidants on male infertilityC Ross
Assisted Conception Unit, Guy s and St Thomas Hospital NHS Foundation Trust, 11th Floor Tower Wing, Guy s Hospital, St Thomas Street, London SE19RT, UK
Reprod Biomed Online 20:711-23. 2010..The use of oral antioxidants in infertile men could improve sperm quality and pregnancy rates. Adequately powered robust trials of individual and combinations of antioxidants are needed to guide clinical practice... - Validity of the in vitro fertilisation league tables: influence of patients' characteristicsA Johnson
Assisted Conception Unit, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
BJOG 114:1569-74. 2007..This study confirms the impact of the non-IVF-related patient characteristics on treatment outcome and the poor validity of comparing IVF clinics' success rates based on the sparse data published by national IVF registries... - Assisted hatching is more effective when embryo quality was optimal in previous failed IVF/ICSI cyclesJ Grace
Assisted Conception Unit, King s College London, School of Medicine, Guy s and St Thomas Hospital, London, UK
J Obstet Gynaecol 27:56-60. 2007.... - Screening for HIV, hepatitis B and C infection in a population seeking assisted reproduction in an inner London hospitalR Hart
Guy's and St Thomas' Assisted Conception Unit, St Thomas' Hospital, London, UK
BJOG 108:654-6. 2001..Detection of infection in one partner should no longer preclude fertility treatment... - Ovarian hyperstimulation syndrome and its effect on renal function in a renal transplant patient undergoing IVF treatment: case reportY Khalaf
Assisted Conception Unit, Guy s and St Thomas Assisted Conception Unit, St Thomas Hospital, London, UK
Hum Reprod 15:1275-7. 2000..No other systemic manifestations of OHSS were evident. Conservative management was successful and a twin live birth was later achieved by replacement of two frozen-thawed embryos... - A randomized controlled trial of prophylactic antibiotics (co-amoxiclav) prior to embryo transferN Brook
Assisted Conception Unit, Guy's and St Thomas's Hospital Foundation Trust, London, UK
Hum Reprod 21:2911-5. 2006..Our findings do not support the routine use of antibiotics at embryo transfer... - Evaluation of perioperative morbidity associated with single and multiple myomectomyK Kunde
Department of Women s Health, Guy s and St Thomas Hospital, London, UK
J Obstet Gynaecol 29:737-41. 2009..73 vs 5.98 days. It was concluded that myomectomy is a relatively safe operation with low incidence of serious morbidity. Haemorrhage is the commonest complication and more likely during multiple myomectomy... - Three hundred and thirty cycles of preimplantation genetic diagnosis for serious genetic disease: clinical considerations affecting outcomeJ Grace
Centre for Preimplantation Genetic Diagnosis, Guy s and St Thomas Foundation Trust, Guy s Hospital, London, UK
BJOG 113:1393-401. 2006..To report on our experience with preimplantation genetic diagnosis (PGD) cycles performed for serious genetic disease in relation to the clinical factors affecting outcome... - Cryo-thawed embryos obtained from conception cycles have double the implantation and pregnancy potential of those from unsuccessful cyclesT El-Toukhy
Assisted Conception Unit, Guy s and St Thomas Hospital NHS Trust, St Thomas Street, London SE1 9RT, UK
Hum Reprod 18:1313-8. 2003..The purpose of this study was to evaluate the influence of fresh IVF/ICSI cycle outcome on the prognosis of the related frozen embryo replacement (FER) cycle... - Meiotic segregation of Robertsonian translocations ascertained in cleavage-stage embryos--implications for preimplantation genetic diagnosisS M Bint
Guy s and St Thomas Centre for Preimplantation Genetic Diagnosis, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
Hum Reprod 26:1575-84. 2011.... - Increasing the gonadotrophin dose in the course of an in vitro fertilization cycle does not rectify an initial poor responseY Khalaf
Assisted Conception Unit, 4th Floor Thomas Guy House, Guy's Hospital, St. Thomas' Street, SE1 9RT, London, UK
Eur J Obstet Gynecol Reprod Biol 103:146-9. 2002..4%) compared to group B. All differences were statistically significant. CONCLUSION: The poor outcome of cycles with initial low response to COH appears not to be averted by doubling or increasing the hMG dose after 5 days of stimulation... - First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform moleC Mackie Ogilvie
Genetics Centre, Guy s and St Thomas Hospital NHS Foundation Trust, London, UK
Reprod Biomed Online 19:224-7. 2009..All embryos showed normal biparental inheritance; one blastocyst was transferred, resulting in the delivery of healthy monozygotic twin girls... - Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trialS Bhattacharya
Assisted Reproduction Unit, Aberdeen University, Aberdeen Maternity Hospital, Foresterhill, AB25 2ZD, Aberdeen, UK
Lancet 357:2075-9. 2001..6-56.6). INTERPRETATION: ICSI offers no advantage over IVF in terms of clinical outcome in cases of non-male-factor infertility. Our results support the current practice of reserving ICSI only for severe male-factor problems...