Research Topics
Genomes and Genes | David L H BennettSummaryAffiliation: King's College London Country: UK Publications
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Publications
Neurotrophic factors: important regulators of nociceptive functionD L Bennett
Dept Physiology, St Thomas Hospital Medical School, Lambeth Palace Rd, London, SE1 7EH, UK
Neuroscientist 7:13-7. 2001..This review highlights some of the key roles played by these molecules and in particular the role of NGF in the peripheral sensitization of nociceptors and brain-derived neurotrophic factor (BDNF) as a central pain modulator...
Artemin has potent neurotrophic actions on injured C-fibresDavid L H Bennett
Wolfson Centre for Age Related Disease, King s College London, Guy s Campus, London, UK
J Peripher Nerv Syst 11:330-45. 2006..Given the potent neurotrophic actions of ARTN on C-fibres, it may therefore provide potential for the treatment of nerve injury, particularly in the maintenance of small fibre function...
The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective studyD L H Bennett
Department of Neurorestoration, CARD Wolfson Wing, Hodgkin Building, Guy s Campus, King s College London, London Bridge, London SE11UL, UK
J Neurol Neurosurg Psychiatry 79:1376-81. 2008..Previous studies have suggested that combined nerve and muscle biopsy (usually of the superficial peroneal nerve and peroneus brevis muscle) produces a higher diagnostic yield than nerve biopsy alone in the investigation of vasculitis...
Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthoodFlorence R Fricker
Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
J Neurosci 31:3225-33. 2011..Juxtacrine Neuregulin-1 signaling is therefore dispensable for maintenance of the myelin sheath in adult animals but has a key role in reparative processes after nerve injury...
CXCL5 mediates UVB irradiation-induced painJohn M Dawes
Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, UK
Sci Transl Med 3:90ra60. 2011..Our findings demonstrate that the chemokine CXCL5 is a peripheral mediator of UVB-induced inflammatory pain, likely in humans as well as rats...
Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenanceFlorence R Fricker
Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
J Neurosci 29:7667-78. 2009..Sensory neuronal survival and axonal maintenance, however, are not dependent on axon-derived neuregulin-1 signaling in adulthood...
A gain-of-function mutation in TRPA1 causes familial episodic pain syndromeBarbara Kremeyer
Department of Genetics, Evolution and Environment, University College London, London, UK
Neuron 66:671-80. 2010..TRPA1 antagonists inhibit the mutant channel, promising a useful therapy for this disorder. Our findings provide evidence that variation in the TRPA1 gene can alter pain perception in humans...
Following nerve injury neuregulin-1 drives microglial proliferation and neuropathic pain via the MEK/ERK pathwayMargarita Calvo
Wolfson CARD, Kings College London, Hodgkin Building, Guys Campus, SE1 1UL, London, United Kingdom
Glia 59:554-68. 2011....
Molecular forms of NGF in human and rat neuropathic tissues: decreased NGF precursor-like immunoreactivity in human diabetic skinYiangos Yiangou
Peripheral Neuropathy Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
J Peripher Nerv Syst 7:190-7. 2002..The different molecular forms derived from prepro-NGF are likely to be of importance in sensory mechanisms, and deserve further investigation...
