J C Manson

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy
    J C Manson
    BBSRC Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh EH9 3JF
    EMBO J 18:6855-64. 1999
  2. ncbi The transmissible spongiform encephalopathies: emerging and declining epidemics
    J C Manson
    Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK
    Biochem Soc Trans 34:1155-8. 2006
  3. ncbi Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers
    R M Barron
    Institute for Animal Health, Neuropathogenesis Unit, Edinburgh, UK
    EMBO J 20:5070-8. 2001
  4. ncbi Comparison of expression patterns of PrP mRNA in the developing sheep and mouse
    N Hunter
    Institute for Animal Health, AFRC/MRC Neuropathogenesis Unit, Edinburgh, Scotland
    Ann N Y Acad Sci 724:353-4. 1994
  5. ncbi Predicting susceptibility and incubation time of human-to-human transmission of vCJD
    M T Bishop
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh, UK
    Lancet Neurol 5:393-8. 2006
  6. ncbi PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology
    J C Manson
    Institute for Animal Health, BBSRC and MRC Neuropathogenesis Unit, Edinburgh
    Neurodegeneration 3:331-40. 1994
  7. ncbi Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations
    R C Moore
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland
    Biotechnology (N Y) 13:999-1004. 1995
  8. ncbi Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent
    R C Moore
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nat Genet 18:118-25. 1998
  9. ncbi Altered circadian activity rhythms and sleep in mice devoid of prion protein
    I Tobler
    Institute of Pharmacology, University of Zurich, Switzerland
    Nature 380:639-42. 1996
  10. ncbi 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal
    J C Manson
    Institute for Animal Health, Edinburgh
    Mol Neurobiol 8:121-7. 1994

Collaborators

Detail Information

Publications12

  1. ncbi A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy
    J C Manson
    BBSRC Neuropathogenesis Unit, Institute for Animal Health, Ogston Building, West Mains Road, Edinburgh EH9 3JF
    EMBO J 18:6855-64. 1999
    ..Additionally, a rapid TSE transmission was demonstrated despite extremely low levels of disease-associated PrP...
  2. ncbi The transmissible spongiform encephalopathies: emerging and declining epidemics
    J C Manson
    Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, Scotland, UK
    Biochem Soc Trans 34:1155-8. 2006
    ..This review examines the emergence of various TSE strains and their transmission, and discusses disease surveillance and control...
  3. ncbi Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers
    R M Barron
    Institute for Animal Health, Neuropathogenesis Unit, Edinburgh, UK
    EMBO J 20:5070-8. 2001
    ..These findings suggest a critical role for the structurally 'flexible' region of PrP in agent replication and targeting of TSE pathology...
  4. ncbi Comparison of expression patterns of PrP mRNA in the developing sheep and mouse
    N Hunter
    Institute for Animal Health, AFRC/MRC Neuropathogenesis Unit, Edinburgh, Scotland
    Ann N Y Acad Sci 724:353-4. 1994
  5. ncbi Predicting susceptibility and incubation time of human-to-human transmission of vCJD
    M T Bishop
    National CJD Surveillance Unit, Bryan Matthews Building, Western General Hospital, Edinburgh, UK
    Lancet Neurol 5:393-8. 2006
    ..A lengthy preclinical disease is predicted by these models, which may represent a risk for further disease transmission and thus a significant public-health issue...
  6. ncbi PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology
    J C Manson
    Institute for Animal Health, BBSRC and MRC Neuropathogenesis Unit, Edinburgh
    Neurodegeneration 3:331-40. 1994
    ..These results show that signs of disease, vacuolation and PrP deposition are dependent upon PrPc in a rate dependent manner...
  7. ncbi Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations
    R C Moore
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland
    Biotechnology (N Y) 13:999-1004. 1995
    ..We anticipate that this procedure will have applications to the study of human inherited diseases and the development of therapies...
  8. ncbi Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent
    R C Moore
    Institute of Cell and Molecular Biology, University of Edinburgh, UK
    Nat Genet 18:118-25. 1998
    ..Challenge with a mouse-adapted BSE strain results in dramatically shortened incubation times and demonstrates that PrP dimorphisms at codon 108 and/or 189 control incubation time, and that Sinc/Prni and Prnp are congruent...
  9. ncbi Altered circadian activity rhythms and sleep in mice devoid of prion protein
    I Tobler
    Institute of Pharmacology, University of Zurich, Switzerland
    Nature 380:639-42. 1996
    ....
  10. ncbi 129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal
    J C Manson
    Institute for Animal Health, Edinburgh
    Mol Neurobiol 8:121-7. 1994
    ..The mice are being used in experiments designed to address the role of PrP in the pathogenesis of scrapie and the replication of infectivity...
  11. ncbi In vitro amplification and detection of variant Creutzfeldt-Jakob disease PrPSc
    M Jones
    National CJD Surveillance Unit, School of Molecular and Clinical Medicine Pathology, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    J Pathol 213:21-6. 2007
    ....
  12. ncbi Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein
    B S Wong
    Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurochem 76:565-72. 2001
    ..Taken together, these findings are indicative of a role for PrP in oxidative homeostasis in vivo...