R K Beal

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi Antibody response to Salmonella: its induction and role in protection against avian enteric salmonellosis
    Richard K Beal
    Institute for Animal Health, Enteric Immunology Group, Division of Immunology, Compton, Newbury, Berkshire, RG20 7NN, UK
    Expert Rev Anti Infect Ther 5:873-81. 2007
  2. ncbi Cross-reactive cellular and humoral immune responses to Salmonella enterica serovars Typhimurium and Enteritidis are associated with protection to heterologous re-challenge
    R K Beal
    Division of Immunology, Institute for Animal Health, Compton, Newbury RG20 7NN, UK
    Vet Immunol Immunopathol 114:84-93. 2006
  3. ncbi Age at primary infection with Salmonella enterica serovar Typhimurium in the chicken influences persistence of infection and subsequent immunity to re-challenge
    R K Beal
    Division of Immunology and Immunopathology, Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK
    Vet Immunol Immunopathol 100:151-64. 2004
  4. ncbi Temporal dynamics of the cellular, humoral and cytokine responses in chickens during primary and secondary infection with Salmonella enterica serovar Typhimurium
    R K Beal
    Enteric Immunology Group, Division of Immunopathology, Institute for Animal Health, Compton, Berkshire, UK
    Avian Pathol 33:25-33. 2004
  5. ncbi Clearance of enteric Salmonella enterica serovar Typhimurium in chickens is independent of B-cell function
    Richard K Beal
    Division of Immunology, Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Infect Immun 74:1442-4. 2006
  6. ncbi A strong antigen-specific T-cell response is associated with age and genetically dependent resistance to avian enteric salmonellosis
    Richard K Beal
    Division of Immunology, Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Infect Immun 73:7509-16. 2005
  7. ncbi Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium
    Muhammad Iqbal
    Division of Immunology and Pathology, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    Infect Immun 73:2344-50. 2005
  8. ncbi Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens
    Victoria J Philbin
    Division of Immunology and Pathology, Compton Laboratory, Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Immunology 114:507-21. 2005
  9. ncbi Regional and global changes in TCRalphabeta T cell repertoires in the gut are dependent upon the complexity of the enteric microflora
    William N Mwangi
    Division of Immunology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Dev Comp Immunol 34:406-17. 2010
  10. ncbi Infection of the reproductive tract and eggs with Salmonella enterica serovar pullorum in the chicken is associated with suppression of cellular immunity at sexual maturity
    Paul Wigley
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom
    Infect Immun 73:2986-90. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Antibody response to Salmonella: its induction and role in protection against avian enteric salmonellosis
    Richard K Beal
    Institute for Animal Health, Enteric Immunology Group, Division of Immunology, Compton, Newbury, Berkshire, RG20 7NN, UK
    Expert Rev Anti Infect Ther 5:873-81. 2007
    ..However, depletion of B cells and, therefore, removal of the capacity for antibody production in the chicken does not exacerbate the infection following either primary or secondary challenge...
  2. ncbi Cross-reactive cellular and humoral immune responses to Salmonella enterica serovars Typhimurium and Enteritidis are associated with protection to heterologous re-challenge
    R K Beal
    Division of Immunology, Institute for Animal Health, Compton, Newbury RG20 7NN, UK
    Vet Immunol Immunopathol 114:84-93. 2006
    ..The substantial level of cross-protection between serovars and the level of antigenic cross-reactivity indicates the potential for single serovar live vaccines to protect against both group B and D salmonellae...
  3. ncbi Age at primary infection with Salmonella enterica serovar Typhimurium in the chicken influences persistence of infection and subsequent immunity to re-challenge
    R K Beal
    Division of Immunology and Immunopathology, Institute for Animal Health, Compton Laboratory, Compton, Newbury RG20 7NN, UK
    Vet Immunol Immunopathol 100:151-64. 2004
    ..This feature of the development of protective immunity needs to be considered when developing vaccines for the broiler sector of the poultry industry...
  4. ncbi Temporal dynamics of the cellular, humoral and cytokine responses in chickens during primary and secondary infection with Salmonella enterica serovar Typhimurium
    R K Beal
    Enteric Immunology Group, Division of Immunopathology, Institute for Animal Health, Compton, Berkshire, UK
    Avian Pathol 33:25-33. 2004
    ....
  5. ncbi Clearance of enteric Salmonella enterica serovar Typhimurium in chickens is independent of B-cell function
    Richard K Beal
    Division of Immunology, Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Infect Immun 74:1442-4. 2006
    ..Infection induces high levels of specific antibody, but B cells do not play an essential role in clearance of primary infection or in the enhanced clearance after secondary challenge...
  6. ncbi A strong antigen-specific T-cell response is associated with age and genetically dependent resistance to avian enteric salmonellosis
    Richard K Beal
    Division of Immunology, Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Infect Immun 73:7509-16. 2005
    ..The data presented here implicate T-cell responses in the clearance of S. enterica serovar Typhimurium from the intestine of infected chickens...
  7. ncbi Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium
    Muhammad Iqbal
    Division of Immunology and Pathology, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    Infect Immun 73:2344-50. 2005
    ..Collectively, the data represent the identification and functional characterization of a nonmammalian TLR5 and indicate a role in restricting the entry of flagellated Salmonella into systemic sites of the chicken...
  8. ncbi Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens
    Victoria J Philbin
    Division of Immunology and Pathology, Compton Laboratory, Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Immunology 114:507-21. 2005
    ..The deletion of TLR8 in galliforms, accompanied with the differential response after exposure to TLR7 agonists, offers insight into the evolution of vertebrate TLR function...
  9. ncbi Regional and global changes in TCRalphabeta T cell repertoires in the gut are dependent upon the complexity of the enteric microflora
    William N Mwangi
    Division of Immunology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Dev Comp Immunol 34:406-17. 2010
    ..These data indicate the dramatic influence of enteric microflora complexity on the profile of TCRbeta repertoire in the gut at local and global levels...
  10. ncbi Infection of the reproductive tract and eggs with Salmonella enterica serovar pullorum in the chicken is associated with suppression of cellular immunity at sexual maturity
    Paul Wigley
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Leahurst, Neston CH64 7TE, United Kingdom
    Infect Immun 73:2986-90. 2005
    ....
  11. ncbi Two CD1 genes map to the chicken MHC, indicating that CD1 genes are ancient and likely to have been present in the primordial MHC
    Jan Salomonsen
    Department of Pathobiology, Laboratory of Immunology, Royal Veterinary and Agricultural University, Stigbøjlen 7, DK 1870 Frederiksberg C, Denmark
    Proc Natl Acad Sci U S A 102:8668-73. 2005
    ..The unexpected location of these genes in the chicken MHC suggests the CD1 system was present in the primordial MHC and is thus approximately 600 million years old...