Patricia A Zunszain

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Crystal structural analysis of human serum albumin complexed with hemin and fatty acid
    Patricia A Zunszain
    Department of Biological Sciences, Imperial College London, Room 746 Huxley Building, South Kensington Campus, London SW7 2AZ, United Kingdom
    BMC Struct Biol 3:6. 2003
  2. ncbi Structural basis of the drug-binding specificity of human serum albumin
    Jamie Ghuman
    Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Mol Biol 353:38-52. 2005
  3. ncbi Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha
    Patricia A Zunszain
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington Campus, Exhibition Road, London SW7 2AZ, UK
    J Mol Biol 381:394-406. 2008
  4. ncbi Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin
    Ali J Ryan
    Biophysics Section, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, United Kingdom
    J Struct Biol 174:84-91. 2011
  5. ncbi Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target
    Stephen Curry
    Biophysics Section, Division of Cell and Molecular Biology, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, UK
    Int J Biochem Cell Biol 39:1-6. 2007
  6. ncbi Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia
    Isabelle Petitpas
    Biophysics Section, Department of Biological Sciences, Imperial College London, South Kensington Campus, United Kingdom
    Proc Natl Acad Sci U S A 100:6440-5. 2003
  7. ncbi Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis
    Jeffrey R Simard
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 715 Albany Street Boston, MA 02118, USA
    J Mol Biol 361:336-51. 2006
  8. ncbi O2 and CO binding properties of artificial hemoproteins formed by complexing iron protoporphyrin IX with human serum albumin mutants
    Teruyuki Komatsu
    Advanced Research Institute for Science and Engineering, Waseda University, 3 4 1 Okubo, Shinjuku ku, Tokyo 169 8555, Japan
    J Am Chem Soc 127:15933-42. 2005
  9. ncbi Photosensitized reduction of water to hydrogen using human serum albumin complexed with zinc-protoporphyrin IX
    Teruyuki Komatsu
    Advanced Research Institute for Science and Engineering, Waseda University, 3 4 1 Okubo, Shinjuku ku, Tokyo 169 8555, Japan
    J Am Chem Soc 128:16297-301. 2006
  10. ncbi Genetic engineering of the heme pocket in human serum albumin: modulation of O2 binding of iron protoporphyrin IX by variation of distal amino acids
    Teruyuki Komatsu
    Research Institute for Science and Engineering, Waseda University, 3 4 1 Okubo, Shinjuku ku, Tokyo 169 8555, Japan
    J Am Chem Soc 129:11286-95. 2007

Collaborators

Detail Information

Publications11

  1. ncbi Crystal structural analysis of human serum albumin complexed with hemin and fatty acid
    Patricia A Zunszain
    Department of Biological Sciences, Imperial College London, Room 746 Huxley Building, South Kensington Campus, London SW7 2AZ, United Kingdom
    BMC Struct Biol 3:6. 2003
    ..Although HSA-heme complexes do not bind oxygen reversibly, it may be possible to develop modified HSA proteins or heme groups that will confer this ability on the complex...
  2. ncbi Structural basis of the drug-binding specificity of human serum albumin
    Jamie Ghuman
    Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Mol Biol 353:38-52. 2005
    ..These results clarify the interpretation of accumulated drug binding data and provide a valuable template for design efforts to modulate the interaction with HSA...
  3. ncbi Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha
    Patricia A Zunszain
    Biophysics Section, Blackett Laboratory, Imperial College, South Kensington Campus, Exhibition Road, London SW7 2AZ, UK
    J Mol Biol 381:394-406. 2008
    ....
  4. ncbi Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin
    Ali J Ryan
    Biophysics Section, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, United Kingdom
    J Struct Biol 174:84-91. 2011
    ..They also show that fatty acid binding has only a modest effect on binding of dansylated amino acids to drug site 1 and identify the location of secondary binding sites...
  5. ncbi Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target
    Stephen Curry
    Biophysics Section, Division of Cell and Molecular Biology, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, UK
    Int J Biochem Cell Biol 39:1-6. 2007
    ....
  6. ncbi Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia
    Isabelle Petitpas
    Biophysics Section, Department of Biological Sciences, Imperial College London, South Kensington Campus, United Kingdom
    Proc Natl Acad Sci U S A 100:6440-5. 2003
    ..These structural observations are consistent with binding data showing that HSA retains a high-affinity site for thyroxine in the presence of excess fatty acid that is insensitive to FDH mutations...
  7. ncbi Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis
    Jeffrey R Simard
    Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, 715 Albany Street Boston, MA 02118, USA
    J Mol Biol 361:336-51. 2006
    ..Our results also yield direct insights into the interactions between FA and other ligands...
  8. ncbi O2 and CO binding properties of artificial hemoproteins formed by complexing iron protoporphyrin IX with human serum albumin mutants
    Teruyuki Komatsu
    Advanced Research Institute for Science and Engineering, Waseda University, 3 4 1 Okubo, Shinjuku ku, Tokyo 169 8555, Japan
    J Am Chem Soc 127:15933-42. 2005
    ..Changing Leu-161 to Phe-161 at the distal side increased the association rates of both O2 and CO, which resulted in enhanced binding affinity...
  9. ncbi Photosensitized reduction of water to hydrogen using human serum albumin complexed with zinc-protoporphyrin IX
    Teruyuki Komatsu
    Advanced Research Institute for Science and Engineering, Waseda University, 3 4 1 Okubo, Shinjuku ku, Tokyo 169 8555, Japan
    J Am Chem Soc 128:16297-301. 2006
    ..The efficiency of the photoproduction of H2 was greater than that of the system using the well-known organic chromophore, tetrakis(1-methylpyridinium-4-yl)porphinatozinc(II) (ZnTMPyP4+), under the same conditions...
  10. ncbi Genetic engineering of the heme pocket in human serum albumin: modulation of O2 binding of iron protoporphyrin IX by variation of distal amino acids
    Teruyuki Komatsu
    Research Institute for Science and Engineering, Waseda University, 3 4 1 Okubo, Shinjuku ku, Tokyo 169 8555, Japan
    J Am Chem Soc 129:11286-95. 2007
    ....
  11. ncbi Dioxygenation of human serum albumin having a prosthetic heme group in a tailor-made heme pocket
    Teruyuki Komatsu
    Advanced Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan
    J Am Chem Soc 126:14304-5. 2004
    ....