Claire L Shovlin

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism
    Claire L Shovlin
    NHLI Cardiovascular Sciences, Imperial College London, UK
    Thromb Haemost 98:1031-9. 2007
  2. ncbi Post-NICE 2008: Antibiotic prophylaxis prior to dental procedures for patients with pulmonary arteriovenous malformations (PAVMs) and hereditary haemorrhagic telangiectasia
    C Shovlin
    NHLI Cardiovascular Sciences, Imperial College London Respiratory Medicine, Imperial College Healthcare NHS Trust, London
    Br Dent J 205:531-3. 2008
  3. ncbi Flight-related complications are infrequent in patients with hereditary haemorrhagic telangiectasia/pulmonary arteriovenous malformations, despite low oxygen saturations and anaemia
    Christopher G Mason
    Department of Respiratory Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Thorax 67:80-1. 2012
  4. ncbi Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment
    Claire L Shovlin
    NHLI Cardiovascular Sciences, Imperial College London, UK and HHTIC London, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
    Blood Rev 24:203-19. 2010
  5. ncbi Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2, Sprouty4 and other interval genes
    Fatima S Govani
    NHLI Cardiovascular Sciences, Imperial College London, UK, Hammersmith Campus, Du Cane Rd, London W12 0NN, UK
    J Angiogenes Res 2:15. 2010
  6. ncbi Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia
    C L Shovlin
    NHLI Cardiovascular Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Thorax 63:259-66. 2008
  7. ncbi Embolisation of pulmonary arteriovenous malformations: no consistent effect on pulmonary artery pressure
    C L Shovlin
    NHLI Cardiovascular Sciences Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Eur Respir J 32:162-9. 2008
  8. ncbi Estimates of maternal risks of pregnancy for women with hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): suggested approach for obstetric services
    C L Shovlin
    NHLI Cardiovascular Sciences, Imperial College London, London, UK
    BJOG 115:1108-15. 2008
  9. ncbi Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension
    Claire L Shovlin
    National Heart and Lung Institute Cardiovascular Sciences, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9154. 2010
  10. ncbi Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia
    John A Livesey
    Imperial College School of Medicine, Imperial College, London, UK
    Thorax 67:328-33. 2012

Collaborators

  • D Wray
  • James S O'Donnell
  • KKN Namboodri
  • P L Lasjaunias
  • Fatima S Govani
  • Christopher G Mason
  • John A Livesey
  • M E Begbie
  • Jonathan L Hart
  • S G Cole
  • G M F Wallace
  • P Gupta
  • Michael A Laffan
  • James E Jackson
  • John H Meek
  • Richard A Manning
  • Elena Kulinskaya
  • Zaid Aldin
  • Philip Braude
  • James Jackson
  • J E Jackson
  • J Curtis
  • J M B Hughes
  • C Mordin

Detail Information

Publications16

  1. ncbi Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism
    Claire L Shovlin
    NHLI Cardiovascular Sciences, Imperial College London, UK
    Thromb Haemost 98:1031-9. 2007
    ..In conclusion, HHT-related elevation of FVIII:Ag levels may influence thrombotic risk in HHT. Individualised risk-benefit considerations may be helpful in HHT management...
  2. ncbi Post-NICE 2008: Antibiotic prophylaxis prior to dental procedures for patients with pulmonary arteriovenous malformations (PAVMs) and hereditary haemorrhagic telangiectasia
    C Shovlin
    NHLI Cardiovascular Sciences, Imperial College London Respiratory Medicine, Imperial College Healthcare NHS Trust, London
    Br Dent J 205:531-3. 2008
    ....
  3. ncbi Flight-related complications are infrequent in patients with hereditary haemorrhagic telangiectasia/pulmonary arteriovenous malformations, despite low oxygen saturations and anaemia
    Christopher G Mason
    Department of Respiratory Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Thorax 67:80-1. 2012
    ..Nosebleeds that can bar individuals from boarding a flight occurred in 13.6% (11.5% to 15.8%) of long-haul flights. The findings should influence preflight advice...
  4. ncbi Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment
    Claire L Shovlin
    NHLI Cardiovascular Sciences, Imperial College London, UK and HHTIC London, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
    Blood Rev 24:203-19. 2010
    ..This review will focus on the new evidence and concepts in this complex and fascinating condition, placing these in context for both clinicians and scientists, with a particular emphasis on haematological settings...
  5. ncbi Fine mapping of the hereditary haemorrhagic telangiectasia (HHT)3 locus on chromosome 5 excludes VE-Cadherin-2, Sprouty4 and other interval genes
    Fatima S Govani
    NHLI Cardiovascular Sciences, Imperial College London, UK, Hammersmith Campus, Du Cane Rd, London W12 0NN, UK
    J Angiogenes Res 2:15. 2010
    ....
  6. ncbi Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia
    C L Shovlin
    NHLI Cardiovascular Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Thorax 63:259-66. 2008
    ..Brain abscesses and ischaemic strokes complicate pulmonary arteriovenous malformations (PAVMs). At risk individuals are poorly recognised. Stroke/abscess risk factors have not been defined...
  7. ncbi Embolisation of pulmonary arteriovenous malformations: no consistent effect on pulmonary artery pressure
    C L Shovlin
    NHLI Cardiovascular Sciences Unit, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Eur Respir J 32:162-9. 2008
    ..In the present series of patients, which excluded those with severe pulmonary hypertension, pulmonary artery pressure was not increased significantly by pulmonary arteriovenous malformation embolisation...
  8. ncbi Estimates of maternal risks of pregnancy for women with hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): suggested approach for obstetric services
    C L Shovlin
    NHLI Cardiovascular Sciences, Imperial College London, London, UK
    BJOG 115:1108-15. 2008
    ..Our aim was to estimate rates and types of major complications of HHT in pregnancy, to guide management decisions...
  9. ncbi Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension
    Claire L Shovlin
    National Heart and Lung Institute Cardiovascular Sciences, Imperial College London, London, United Kingdom
    PLoS ONE 5:e9154. 2010
    ..Extrahepatic sources of plasma FVIII are implicated, but have remained elusive...
  10. ncbi Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia
    John A Livesey
    Imperial College School of Medicine, Imperial College, London, UK
    Thorax 67:328-33. 2012
    ..Elevated plasma levels of coagulation factor VIII are a strong risk factor for pulmonary emboli and deep venous thromboses...
  11. ncbi Embolization of pulmonary arteriovenous malformations using the Amplatzer vascular plug: successful treatment of 69 consecutive patients
    Jonathan L Hart
    Department of Imaging, Imperial College Healthcare NHS Trust, London, England
    Eur Radiol 20:2663-70. 2010
    ..The purpose of this study is to assess the role of AVPs in the treatment of PAVMs...
  12. ncbi Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century
    M E Begbie
    Respiratory Medicine, National Heart and Lung Institute, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
    Postgrad Med J 79:18-24. 2003
    ..This review focuses on the evolving evidence base for HHT management, issues regarding pregnancy and prothrombotic treatments, and discusses the molecular and cellular changes that underlie this disease...
  13. ncbi Pulmonary arteriovenous malformations: effect of embolization on right-to-left shunt, hypoxemia, and exercise tolerance in 66 patients
    P Gupta
    Department of Imaging, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Rd, London W12 0NN, England
    AJR Am J Roentgenol 179:347-55. 2002
    ..Coil embolization of pulmonary arteriovenous malformations is well tolerated and has a low complication rate...
  14. ncbi Hereditary haemorrhagic telangiectasia: a clinical and scientific review
    Fatima S Govani
    NHLI Cardiovascular Sciences, Imperial College London, London, UK
    Eur J Hum Genet 17:860-71. 2009
    ....
  15. ncbi A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5
    S G Cole
    The Eric Bywaters Centre, Respiratory Section, National Heart and Lung Institute, Imperial College Faculty of Medicine, Hammersmith Hospital, London W12 ONN, UK
    J Med Genet 42:577-82. 2005
    ..Identification of HHT3 should further illuminate HHT pathogenic mechanisms in which aberrant transforming growth factor (TGF)-beta signalling is implicated...
  16. ncbi Supermodels and disease: insights from the HHT mice
    C L Shovlin
    Respiratory Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    J Clin Invest 104:1335-6. 1999