Felix M Munkonge

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Emerging significance of plasmid DNA nuclear import in gene therapy
    Felix M Munkonge
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Adv Drug Deliv Rev 55:749-60. 2003
  2. ncbi Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import
    Felix M Munkonge
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LR, United Kingdom
    J Biol Chem 284:26978-87. 2009
  3. ncbi Limitations of the murine nose in the development of nonviral airway gene transfer
    Uta Griesenbach
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, Manresa Road, London SW3 6LR, UK
    Am J Respir Cell Mol Biol 43:46-54. 2010
  4. ncbi Nondisruptive, sequence-specific coupling of fluorochromes to plasmid DNA
    Elizabeth Hillery
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LR, UK
    Anal Biochem 352:169-75. 2006
  5. ncbi The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways
    Uta Griesenbach
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London SW3 6LR, UK
    Biomaterials 31:2665-72. 2010
  6. ncbi Assessment of CFTR function after gene transfer in vitro and in vivo
    Uta Griesenbach
    Department of Gene Therapy, Faculty of Medicine, Imperial College London, UK
    Methods Mol Biol 433:229-42. 2008
  7. ncbi The efficacy of a 'master switch gene' HIF-1alpha in a porcine model of chronic myocardial ischaemia
    Amanda Heinl-Green
    Department of Gene Therapy, Faculty of Medicine, The National Heart and Lung Institute, Imperial College London, Manresa Road, London SW3 6LR, UK
    Eur Heart J 26:1327-32. 2005
  8. ncbi CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
    Stephen C Hyde
    Gene Medicine Research Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK
    Nat Biotechnol 26:549-51. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Emerging significance of plasmid DNA nuclear import in gene therapy
    Felix M Munkonge
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Adv Drug Deliv Rev 55:749-60. 2003
    ....
  2. ncbi Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import
    Felix M Munkonge
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LR, United Kingdom
    J Biol Chem 284:26978-87. 2009
    ..Increasing the potential for exogenously added pDNA to bind intracellular transport cofactors may enhance the potency of non-viral gene transfer...
  3. ncbi Limitations of the murine nose in the development of nonviral airway gene transfer
    Uta Griesenbach
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, Manresa Road, London SW3 6LR, UK
    Am J Respir Cell Mol Biol 43:46-54. 2010
    ..At the current levels of gene transfer efficiency achievable with nonviral vectors, the murine nose is of limited value as a stepping stone to human trials...
  4. ncbi Nondisruptive, sequence-specific coupling of fluorochromes to plasmid DNA
    Elizabeth Hillery
    Department of Gene Therapy, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW3 6LR, UK
    Anal Biochem 352:169-75. 2006
    ..Thus, this method allows for the sequence-specific coupling of commercially available fluorochromes to DNA expression vectors while retaining biological function...
  5. ncbi The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways
    Uta Griesenbach
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London SW3 6LR, UK
    Biomaterials 31:2665-72. 2010
    ..0001, n=18). This study suggests that contact time of non-viral gene transfer agents is a key factor for gene delivery, and suggests two methods which may be translatable for use in man...
  6. ncbi Assessment of CFTR function after gene transfer in vitro and in vivo
    Uta Griesenbach
    Department of Gene Therapy, Faculty of Medicine, Imperial College London, UK
    Methods Mol Biol 433:229-42. 2008
    ..Here, we describe pre-clinical methods related to assessing correction of the CF chloride transport defect...
  7. ncbi The efficacy of a 'master switch gene' HIF-1alpha in a porcine model of chronic myocardial ischaemia
    Amanda Heinl-Green
    Department of Gene Therapy, Faculty of Medicine, The National Heart and Lung Institute, Imperial College London, Manresa Road, London SW3 6LR, UK
    Eur Heart J 26:1327-32. 2005
    ..Therapeutic angiogenesis is a potential new treatment for patients unsuitable for conventional revascularization strategies. We investigated angiogenesis via a 'master switch gene' hypoxia inducible factor (HIF-1alpha)...
  8. ncbi CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
    Stephen C Hyde
    Gene Medicine Research Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK
    Nat Biotechnol 26:549-51. 2008
    ..Using a CpG-free pDNA expression vector, we achieved sustained (>or=56 d) in vivo transgene expression in the absence of lung inflammation...