Julia J Inglis

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 56:4015-23. 2007
  2. ncbi Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3110-9. 2008
  3. ncbi Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    Clare A Notley
    Kennedy Institute of Rheumatology Division, Imperial College London, London, W6 8LH, England, UK
    J Exp Med 205:2491-7. 2008
  4. ncbi Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    Fiona E McCann
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 12:R107. 2010
  5. ncbi Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 149:386-92. 2010
  6. ncbi Protocol for the induction of arthritis in C57BL/6 mice
    Julia J Inglis
    Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Nat Protoc 3:612-8. 2008
  7. ncbi ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis
    Clare A Notley
    Imperial College London, London, UK
    Arthritis Rheum 62:171-8. 2010
  8. ncbi Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 9:R113. 2007
  9. ncbi Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis
    Gabriel Criado
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 60:1342-51. 2009
  10. ncbi IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 152:1838-45. 2011

Detail Information

Publications15

  1. ncbi Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 56:4015-23. 2007
    ..We then validated the model using anti-tumor necrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as in human RA...
  2. ncbi Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3110-9. 2008
    ..However, up to 40% of individuals with radiologic damage are asymptomatic. The purpose of this study was to assess the role of the endogenous opioid system in delaying the onset of pain in a murine model of osteoarthritis (OA)...
  3. ncbi Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    Clare A Notley
    Kennedy Institute of Rheumatology Division, Imperial College London, London, W6 8LH, England, UK
    J Exp Med 205:2491-7. 2008
    ....
  4. ncbi Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    Fiona E McCann
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 12:R107. 2010
    ..We assessed the anti-inflammatory effects of a novel PDE4 inhibitor, apremilast, in human synovial cells from rheumatoid arthritis (RA) patients, as well as two murine models of arthritis...
  5. ncbi Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 149:386-92. 2010
    ..They also suggest that, unlike post-operative pain, induction of pain in OA may not necessarily be driven by classical inflammatory processes...
  6. ncbi Protocol for the induction of arthritis in C57BL/6 mice
    Julia J Inglis
    Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Nat Protoc 3:612-8. 2008
    ..The incidence of arthritis varies from 50 to 80% and is milder than the classical collagen-induced arthritis model. This procedure takes approximately 3 months to complete...
  7. ncbi ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis
    Clare A Notley
    Imperial College London, London, UK
    Arthritis Rheum 62:171-8. 2010
    ..To assess the therapeutic potential of anti-CD3 monoclonal antibodies (mAb) for rheumatoid arthritis, using collagen-induced arthritis as an animal model...
  8. ncbi Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 9:R113. 2007
    ....
  9. ncbi Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis
    Gabriel Criado
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 60:1342-51. 2009
    ..The aim of this study was to investigate the regulation of collagen-induced arthritis by tryptophan catabolism mediated by IDO...
  10. ncbi IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 152:1838-45. 2011
    ..The subsequent production of keratinocyte chemoattractant then triggers neutrophil chemotaxis to the plantar tissue, releasing algesic mediators locally to sensitise the nerve...
  11. ncbi The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation
    Julia J Inglis
    Bone and Joint Research Unit, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London, UK
    Arthritis Res Ther 7:R807-16. 2005
    ..These results highlight the potential for TNF to play a vital role in inflammatory hyperalgesia, both by a direct action on neurons via TNFR1 and by facilitating the accumulation of macrophages in the DRG via a TNFR2-mediated pathway...
  12. ncbi Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood
    Theresa H Page
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 185:3694-701. 2010
    ..Thus, by reducing the level of PGE(2), NSAIDs can increase TNF production and may exacerbate the proinflammatory environment both within the rheumatoid arthritis joint and the systemic environment...
  13. ncbi Analysing the effect of novel therapies on cytokine expression in experimental arthritis
    Richard O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, London, UK
    Int J Exp Pathol 86:267-78. 2005
    ..In this review, we outline the various techniques used to detect cytokines in experimental arthritis and describe how these techniques have been used to quantify changes in cytokine expression following therapeutic intervention...
  14. ncbi In vivo fluorescence imaging of E-selectin: quantitative detection of endothelial activation in a mouse model of arthritis
    Luke L Gompels
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 63:107-17. 2011
    ..The purpose of this study was to demonstrate E-selectin-targeted fluorescence imaging in vivo in a mouse model of paw edema generated by local injection of TNF? as well as in mice with CIA...
  15. ncbi Inhibition of inflammation and hyperalgesia in NK-1 receptor knock-out mice
    Bruce L Kidd
    Barts and the London School of Medicine, Queen Mary University of London, London, UK
    Neuroreport 14:2189-92. 2003
    ..The results point to a previously unrecognised influence of substance P on peripheral tissue injury and the maintenance of hyperalgesia during more severe or more chronic phases of inflammatory disease...