Research Topics
| N S HopkinsonSummaryAffiliation: Imperial College Country: UK Publications
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Detail Information
Publications
Non-invasive ventilation (NIV) as an aid to rehabilitation in acute respiratory diseaseFran Dyer
The NIHR Respiratory Biomedical Research Unit at Royal Brompton, London, UK
BMC Pulm Med 11:58. 2011..It is not known whether it can be applied to increase exercise capacity in patients admitted with non-hypercapnic acute exacerbations of COPD (AECOPD). We investigated the acceptability and feasibility of using NIV for this purpose...- Designing and implementing a COPD discharge care bundleNicholas S Hopkinson
NIHR Collaboration for Leadership in Applied Health Research and Care for North West London, Chelsea and Westminster NHS Foundation Trust, London, UK
Thorax 67:90-2. 2012..Implementation of a care bundle has the potential to produce a dramatic improvement in compliance with optimum health care practice... - Atelectasis and survival after bronchoscopic lung volume reduction for COPDN S Hopkinson
NIHR Respiratory Disease Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, National Heart and Lung Institute, Royal Brompton Hospital campus, London, SW3 6NP, UK
Eur Respir J 37:1346-51. 2011..6±2.9 versus 28.4±2.9 kg·m(-2); p<0.001). The data in the present study suggest that atelectasis following BLVR is associated with a survival benefit that is not explained by baseline differences... - Abdominal muscle fatigue following exercise in chronic obstructive pulmonary diseaseNicholas S Hopkinson
National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, UK
Respir Res 11:15. 2010..In healthy subjects, prior expiratory muscle fatigue has been shown itself to contribute to the development of quadriceps fatigue. It is not known whether fatigue of the abdominal muscles occurs during exercise in COPD... - Does physical inactivity cause chronic obstructive pulmonary disease?Nicholas S Hopkinson
National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London SW3 6NP, UK
Clin Sci (Lond) 118:565-72. 2010..There is sufficient evidence to justify population trials of lifestyle interventions aimed at improving physical activity levels and reducing lung function decline in people diagnosed with early COPD through spirometry screening... - Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary diseaseNicholas S Hopkinson
Respiratory Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom
Am J Clin Nutr 87:385-90. 2008..Its etiology is multifactorial, and evidence is growing that it is partly determined by genetic susceptibility... - A prospective study of decline in fat free mass and skeletal muscle strength in chronic obstructive pulmonary diseaseNicholas S Hopkinson
Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, UK
Respir Res 8:25. 2007..We therefore prospectively investigated the impact of disease severity, exacerbation frequency and treatment with corticosteroids on change in body composition and maximum isometric quadriceps strength (QMVC) over one year... - Bronchoscopic lung volume reduction: indications, effects and prospectsNicholas S Hopkinson
Royal Brompton Hospital, London, UK
Curr Opin Pulm Med 13:125-30. 2007..Bronchoscopic techniques are less hazardous than lung volume reduction surgery... - +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary diseaseNicholas S Hopkinson
Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Road, London SW3 6NP, United Kingdom
Am J Clin Nutr 83:912-7. 2006.... - Corticospinal control of respiratory muscles in chronic obstructive pulmonary diseaseNicholas S Hopkinson
Respiratory Muscle Laboratory, Royal Brompton Hospital, London SW3 6NP, UK
Respir Physiol Neurobiol 141:1-12. 2004..These results suggest that there is a ceiling effect in motor control output to the respiratory muscles of patients with COPD... - Acute effect of oral steroids on muscle function in chronic obstructive pulmonary diseaseN S Hopkinson
Respiratory Muscle Laboratory, Royal Brompton Hospital, London, UK
Eur Respir J 24:137-42. 2004..In conclusion, in stable patients with chronic obstructive pulmonary disease, a 2-week course of 30 mg prednisolone daily does not cause significant skeletal muscle dysfunction or alter metabolic parameters during exercise... - Angiotensin converting enzyme genotype and strength in chronic obstructive pulmonary diseaseNicholas S Hopkinson
Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Road, London, SW3 6NP, United Kingdom
Am J Respir Crit Care Med 170:395-9. 2004..In chronic obstructive pulmonary disease the deletion allele is associated with greater quadriceps strength independent of confounding factors... - Effect of bronchoscopic lung volume reduction on dynamic hyperinflation and exercise in emphysemaNicholas S Hopkinson
Respiratory Muscle Laboratory, Department of Respiratory Medicine, Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK
Am J Respir Crit Care Med 171:453-60. 2005..47; p = 0.03). Endobronchial valve placement can improve lung volumes and gas transfer in patients with chronic obstructive pulmonary disease and prolong exercise time by reducing dynamic hyperinflation... - Quadriceps muscle strength in scoliosisE B Swallow
Muscle Laboratory, Royal Brompton Hospital and NHLI, Imperial College, London, UK
Eur Respir J 34:1429-35. 2009..5)% compared with 11.3 (13.0)%, p = 0.01. Quadriceps weakness is a feature of severe scoliosis; the similarities between patients with scoliosis and patients with COPD suggest a common aetiology to quadriceps weakness in both conditions... - Abdominal muscle and quadriceps strength in chronic obstructive pulmonary diseaseW D C Man
Respiratory Muscle Laboratory, Guy s, King s and St Thomas School of Medicine, King s College Hospital, Bessemer Road, London SE5 9PJ, UK
Thorax 60:718-22. 2005..A study was undertaken to test the hypothesis that more severe weakness exists in the quadriceps than in the abdominal muscles of patients with COPD compared with healthy elderly controls... - A novel technique for nonvolitional assessment of quadriceps muscle endurance in humansE B Swallow
Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Rd, London SW3 6NP, United Kingdom
J Appl Physiol 103:739-46. 2007..68, P = 0.004) and CS-to-PFK ratio (CS/PFK) (r = 0.67, P = 0.005). We conclude that quadriceps endurance assessed using rMS is feasible in clinical studies... - Motor control of the costal and crural diaphragm--insights from transcranial magnetic stimulation in manTarek Sharshar
Respiratory Muscle Laboratory, Royal Brompton and Harefield NHS Trust, Fulham Road, London, SW3 6NP, UK
Respir Physiol Neurobiol 146:5-19. 2005..We conclude that supraspinal control of the costal and crural diaphragm is identical during inspiratory tasks... - Depression of diaphragm motor cortex excitability during mechanical ventilationTarek Sharshar
Respiratory Muscle Laboratory, Royal Brompton Hospital, Sydney St, London SW3 6NP UK
J Appl Physiol 97:3-10. 2004..Our results demonstrate that mechanical ventilation directly inhibits central projections to the diaphragm... - Sniff nasal inspiratory pressure versus IC/TLC ratio as predictors of mortality in COPDAlastair J Moore
Royal Brompton Hospital, London SW3 6NP, UK
Respir Med 104:1319-25. 2010..We therefore compared the SnIP to the inspiratory capacity-to-total lung capacity (IC/TLC) ratio as predictors of mortality in advanced COPD... - Effect of voluntary facilitation on the diaphragmatic response to transcranial magnetic stimulationTarek Sharshar
Respiratory Muscle Laboratory, Royal Brompton and Harefield National Health Service, Trust and King s College Hospital, London SW3 6NP, UK
J Appl Physiol 95:26-34. 2003.... - Demonstration of a second rapidly conducting cortico-diaphragmatic pathway in humansTarek Sharshar
Respiratory Muscle Laboratory, Royal Brompton and Harefield NHS Trust, Fulham Road, London SW3 6NP, UK
J Physiol 560:897-908. 2004..We conclude that the two coil positions represent discrete areas that are likely to be the PMC and SMA, with the latter wielding a more excitatory effect on the diaphragm... - Exercise-induced depression of the diaphragm motor evoked potential is not affected by non-invasive ventilationMark J Dayer
Respiratory Muscle Laboratory, Royal Brompton Hospital, London SW3 6NP, United Kingdom
Respir Physiol Neurobiol 155:243-54. 2007..098). We conclude that the work of breathing during whole body exercise is not the primary driver of exercise-induced diaphragm MEP depression... - Does symptom-limited cycle exercise cause low frequency diaphragm fatigue in patients with heart failure?Mark J Dayer
Respiratory Muscle Laboratory, Royal Brompton and Harefield N H S Trust, Royal Brompton Hospital, London, UK
Eur J Heart Fail 8:68-73. 2006..We hypothesised that patients with congestive heart failure (CHF) might be especially vulnerable to the development of low frequency diaphragm fatigue after exhaustive exercise... - Bronchoscopic volume reduction with valve implants in patients with severe emphysemaTudor P Toma
Department of Thoracic Medicine, National Heart and Lung Institute, London, UK
Lancet 361:931-3. 2003..Lung-volume reduction can be achieved with unilateral bronchoscopically placed valve implants in patients with severe emphysema with acceptable short-term safety and worthwhile functional benefits... - Mechanisms of improvement of respiratory failure in patients with COPD treated with NIVAnnabel H Nickol
Respiratory Muscle Laboratory, Royal Brompton Hospital, London, UK
Int J Chron Obstruct Pulmon Dis 3:453-62. 2008..We hypothesized NIV reverses respiratory failure by one or all of increased ventilatory response to carbon-dioxide, reduced respiratory muscle fatigue, or improved pulmonary mechanics... - Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary diseaseElisabeth B Swallow
Respiratory Muscle Laboratory, Royal Brompton Hospital, Fulham Road, London SW3 6NP, UK
Thorax 62:115-20. 2007..Prognosis in chronic obstructive pulmonary disease (COPD) is poorly predicted by indices of air flow obstruction, because other factors that reflect the systemic nature of the disease also influence prognosis... - The COPD assessment test (CAT): response to pulmonary rehabilitation. A multicentre, prospective studyJames W Dodd
St George s Hospital NHS Trust, London, UK
Thorax 66:425-9. 2011..It is not known how the CAT score performs in the context of clinical pulmonary rehabilitation (PR) programmes or what the minimum clinically important difference is... - Singing teaching as a therapy for chronic respiratory disease--a randomised controlled trial and qualitative evaluationVictoria M Lord
Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London SW3 6NP, UK
BMC Pulm Med 10:41. 2010..There is a need to develop additional strategies to alleviate symptoms. Learning to sing requires control of breathing and posture and might have benefits that translate into daily life... - Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposureAli Reza Hosseini-Khalili
UCL Institute for Human Health and Performance, Ground Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, Archway, London N19 5LW, UK
BMC Pulm Med 8:15. 2008..We hypothesized that the ACE genotype might influence the severity of late respiratory complications of mustard gas exposure... - Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shockTarek Sharshar
, , , Ile de France Ouest, Garches, France
Lancet 362:1799-805. 2003..INTERPRETATION: Septic shock is associated with neuronal and glial apoptosis within the autonomic centres, which is strongly associated with endothelial iNOS expression...