Dorian O Haskard

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses
    Karen Y Larbi
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    J Leukoc Biol 73:65-73. 2003
  2. ncbi Interactions between leukocytes and endothelial cells in gout: lessons from a self-limiting inflammatory response
    Dorian O Haskard
    BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Arthritis Res 4:S91-7. 2002
  3. ncbi Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice
    Viola W Y Leung
    Vascular Science Section, Imperial College, National Heart and Lung Institute, the Division of Investigative Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Am J Pathol 175:1757-67. 2009
  4. ncbi JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration
    Abigail Woodfin
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Blood 110:1848-56. 2007
  5. ncbi Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation
    Darshna R Yagnik
    Imperial College London, Hammersmith Hospital, London, UK
    Arthritis Rheum 50:2273-80. 2004
  6. ncbi PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress
    Faisal Ali
    Bywaters Center for Vascular Inflammation, Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cardiovasc Res 85:701-10. 2010
  7. ncbi The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice
    Talat H Malik
    Rheumatology Section, Division of Immunology and Inflammation, Department of Medicine, Imperial College, London, UK
    Circulation 122:1948-56. 2010
  8. ncbi Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin
    Anne R Kinderlerer
    Bywaters Center for Vascular Inflammation, Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK
    Blood 113:1598-607. 2009
  9. ncbi Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice
    Myles J Lewis
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College, Hammersmith Hospital, Du Cane Rd, London, W12 0NN, UK
    Circulation 120:417-26. 2009
  10. ncbi KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature
    Anne R Kinderlerer
    Cardiovascular Sciences, Bywaters Center for Vascular Inflammation, National Heart and Lung Institute, Imperial College London, London, UK
    J Biol Chem 283:14636-44. 2008

Detail Information

Publications63

  1. ncbi P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses
    Karen Y Larbi
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, DuCane Road, London W12 0NN, UK
    J Leukoc Biol 73:65-73. 2003
    ..In conclusion, the regulatory role of P-selectin in leukocyte transmigration elicited by IL-13 appears to be tissue-specific, a phenomenon that is independent of the ability of the cytokine to stimulate eotaxin generation...
  2. ncbi Interactions between leukocytes and endothelial cells in gout: lessons from a self-limiting inflammatory response
    Dorian O Haskard
    BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Arthritis Res 4:S91-7. 2002
    ....
  3. ncbi Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice
    Viola W Y Leung
    Vascular Science Section, Imperial College, National Heart and Lung Institute, the Division of Investigative Sciences, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Am J Pathol 175:1757-67. 2009
    ..Because upstream complement activation is potentially protective, this study underlines the importance of DAF in shielding the arterial wall from the atherogenic effects of complement...
  4. ncbi JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration
    Abigail Woodfin
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Blood 110:1848-56. 2007
    ..The latter appeared to be due to the fact that JAM-A and PECAM-1 can act sequentially to mediate leukocyte migration through venular walls in vivo...
  5. ncbi Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation
    Darshna R Yagnik
    Imperial College London, Hammersmith Hospital, London, UK
    Arthritis Rheum 50:2273-80. 2004
    ..The purpose of this study was to investigate whether MSU crystals induce macrophages to secrete antiinflammatory factor instead...
  6. ncbi PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress
    Faisal Ali
    Bywaters Center for Vascular Inflammation, Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cardiovasc Res 85:701-10. 2010
    ..We investigated the role of PPARdelta and its co-activator, PPARgamma co-activator 1alpha (PGC1alpha), in vasculoprotection against oxidant-induced injury via induction of haem oxygenase-1...
  7. ncbi The alternative pathway is critical for pathogenic complement activation in endotoxin- and diet-induced atherosclerosis in low-density lipoprotein receptor-deficient mice
    Talat H Malik
    Rheumatology Section, Division of Immunology and Inflammation, Department of Medicine, Imperial College, London, UK
    Circulation 122:1948-56. 2010
    ..However, the role of the alternative pathway remained unknown, and that was investigated in this study...
  8. ncbi Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin
    Anne R Kinderlerer
    Bywaters Center for Vascular Inflammation, Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK
    Blood 113:1598-607. 2009
    ....
  9. ncbi Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice
    Myles J Lewis
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College, Hammersmith Hospital, Du Cane Rd, London, W12 0NN, UK
    Circulation 120:417-26. 2009
    ..We have directly investigated the requirement for IgM by studying the effects of IgM deficiency in LDL receptor-deficient (Ldlr(-/-)) mice...
  10. ncbi KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature
    Anne R Kinderlerer
    Cardiovascular Sciences, Bywaters Center for Vascular Inflammation, National Heart and Lung Institute, Imperial College London, London, UK
    J Biol Chem 283:14636-44. 2008
    ..We propose that up-regulation of CD59 via ERK5/KLF2 activation leads to endothelial resistance to complement-mediated injury and protects from atherogenesis in regions of laminar shear stress...
  11. ncbi Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification?
    Imad Nadra
    British Heart Foundation Cardiovascular Medicine Unit, Eric Bywaters Centre for Vascular Inflammation, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK
    Circ Res 96:1248-56. 2005
    ....
  12. ncbi ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration
    Miao Tzu Huang
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
    Blood 107:4721-7. 2006
    ..Furthermore, ICAM-2 appears capable of mediating PECAM-1-independent leukocyte transmigration...
  13. ncbi Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin
    Graeme M Birdsey
    National Heart and Lung Institute Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, UK
    Blood 111:3498-506. 2008
    ..These results identify a new pathway regulating angiogenesis and endothelial survival, via the transcription factor Erg and the adhesion molecule VE-cadherin...
  14. ncbi Sphingosine 1-phosphate enhances Fc gamma receptor-mediated neutrophil activation and recruitment under flow conditions
    Oliver Florey
    British Heart Foundation Cardiovascular Medicine Unit, Imperial College, Hammersmith Hospital, London, United Kingdom
    J Immunol 183:2330-6. 2009
    ..Taken together, S1P from activated platelets or endothelial cells may serve to amplify leukocyte recruitment and tissue injury at sites of immune complex deposition in vasculitis...
  15. ncbi Aprotinin inhibits proinflammatory activation of endothelial cells by thrombin through the protease-activated receptor 1
    Jonathan R S Day
    Eric Bywaters Centre, Imperial College London, Faculty of Medicine, Hammersmith Hospital, London, United Kingdom
    J Thorac Cardiovasc Surg 131:21-7. 2006
    ..Our results provide a new molecular basis to help explain the anti-inflammatory properties of aprotinin reported clinically...
  16. ncbi Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium
    Shahir S Hamdulay
    Cardiovascular Sciences, Bywaters Center for Vascular Inflammation, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London W12 ONN, UK
    Free Radic Biol Med 48:1013-23. 2010
    ..HO-1 induction provides a molecular mechanism for clinical observations indicating relative freedom from atherothrombotic complications in patients taking celecoxib compared to other NSAIDs with comparable anti-inflammatory activity...
  17. ncbi Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis
    Anne R Kinderlerer
    Cardiovascular Medicine Unit, Eric Bywaters Center for Vascular Inflammation, Imperial College London, Hammersmith Hospital, London, UK
    Arthritis Res Ther 8:R130. 2006
    ..The modulation of EC CD59 and DAF by statins under hypoxic conditions therefore inhibits both early and late complement activation and may contribute to the anti-inflammatory effects of statins in RA...
  18. ncbi Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59
    Sheng Yun
    NHLI Cardiovascular Sciences, Imperial College, Hammersmith Hospital, Du Cane Road, London, UK
    Arterioscler Thromb Vasc Biol 28:1714-6. 2008
    ..We tested the hypothesis that the terminal pathway inhibitor CD59 plays an essential role in limiting the proinflammatory effects of complement activation...
  19. ncbi A role for proteinase-activated receptor 2 and PKC-epsilon in thrombin-mediated induction of decay-accelerating factor on human endothelial cells
    Elaine A Lidington
    Cardiovascular Medicine Unit, Imperial College, Hammersmith Hospital, DuCane Road, London W12 ONN, UK
    Am J Physiol Cell Physiol 289:C1437-47. 2005
    ..This may represent an important, novel pathway for endothelial cytoprotection during inflammation and angiogenesis and suggests that PAR2 may play a central role in some thrombin-induced responses...
  20. ncbi Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between Fc{gamma}RIIa and CXCR1/2
    Oliver J Florey
    British Heart Foundation, Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, Du Cane Road, London, UK
    Blood 109:3881-9. 2007
    ..Furthermore, the observation that FcgammaRIIa and CXCR1/2 cooperate to enhance PMN recruitment in the presence of AECAs suggests a mechanism whereby AECAs may augment tissue injury during inflammatory responses...
  21. ncbi Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection
    Joseph J Boyle
    Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK
    Circ Res 110:20-33. 2012
    ..When clearing tissue hemorrhage, macrophages are typically seen storing either iron or lipid. We have recently defined hemorrhage-associated macrophages (HA-mac) as a plaque macrophage population that responds adaptively to IPH...
  22. ncbi A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2
    Rivka Steinberg
    Bywaters Center for Vascular Inflammation and Histopathology Section, Imperial College London, Hammersmith Hospital, London, W12 ONN United Kingdom
    J Biol Chem 282:32288-97. 2007
    ....
  23. ncbi Effect of particle size on hydroxyapatite crystal-induced tumor necrosis factor alpha secretion by macrophages
    Imad Nadra
    British Heart Foundation Cardiovascular Medicine Unit, Eric Bywaters Centre for Vascular Inflammation, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Atherosclerosis 196:98-105. 2008
    ..Microscopic calcific deposits in early stages of atherosclerosis may therefore pose a greater inflammatory risk to the plaque than macroscopically or radiologically visible deposits in more advanced lesions...
  24. ncbi Anti-inflammatory haemoglobin scavenging monocytes are induced following coronary artery bypass surgery
    Pandelis Philippidis
    Cardiothoracic Surgery and Cardiovascular Medicine Units, Imperial College Healthcare NHS Trust, Imperial College London, London, UK
    Eur J Cardiothorac Surg 37:1360-6. 2010
    ..This prospective study aims to assess the effects of coronary artery bypass grafting with and without cardiopulmonary bypass (CPB) on haemoglobin scavenging and anti-inflammatory monocyte behaviour...
  25. ncbi Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, UK
    Arterioscler Thromb Vasc Biol 29:1851-7. 2009
    ..Here we investigated whether the transcription factor Nrf2 regulates EC activation in arteries...
  26. ncbi Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype
    Joseph J Boyle
    Vascular Sciences Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Am J Pathol 174:1097-108. 2009
    ....
  27. ncbi Effect of aprotinin and recombinant variants on platelet protease-activated receptor 1 activation
    Jonathan R S Day
    Eric Bywaters Centre, British Heart Foundation Cardiovascular Medicine Unit, Imperial College, Hammersmith Hospital, London, United Kingdom
    Ann Thorac Surg 81:619-24. 2006
    ....
  28. ncbi Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: a novel antiinflammatory treatment for vein grafts?
    Mustafa Zakkar
    British Heart Fund Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London, UK
    Circulation 123:524-32. 2011
    ..Here, we have tested the hypothesis that p38 MAP kinase activation in response to arterial shear stress (flow) may occur more readily in venous ECs, leading to greater proinflammatory activation...
  29. ncbi Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response
    Betsy J Evans
    BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Blood 107:3593-9. 2006
    ..We hypothesize that LFA-1 shedding may play a role in leukocyte detachment after transendothelial migration and in regulating integrin-dependent outside-in signaling...
  30. ncbi Targeting gene delivery to activated vascular endothelium using anti E/P-Selectin antibody linked to PAMAM dendrimers
    Stefanos Theoharis
    Immunology Department, Imperial College London, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    J Immunol Methods 343:79-90. 2009
    ..We have therefore investigated the potential of targeting PAMAM dendrimers, a non viral vector system, to cells expressing P/E-selectin using a monoclonal antibody that recognises these molecules...
  31. ncbi Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall
    Marc Jevon
    Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
    Cardiovasc Pathol 20:e91-4. 2011
    ..We used an interposition vein graft model to determine the source of neointimal cells in a clinically relevant large animal model...
  32. ncbi Monocyte Fc gamma receptor expression in patients undergoing coronary artery bypass grafting
    Demetrios C Stefanou
    British Heart Foundation, Cardiothoracic Surgery Unit and Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, England, UK
    Ann Thorac Surg 77:951-5. 2004
    ..CONCLUSIONS: Our study demonstrated that cardiopulmonary bypass is associated with a biphasic Fc gamma receptor III expression on a subpopulation of peripheral blood monocytes up to 3 days postoperatively...
  33. ncbi The state of macrophage differentiation determines the TNF alpha response to nitrated lipoprotein uptake
    Cheryl D W Smythe
    BHF Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W120NN, UK
    Atherosclerosis 170:213-21. 2003
    ....
  34. ncbi bFGF and VEGF synergistically enhance endothelial cytoprotection via decay-accelerating factor induction
    Justin C Mason
    British Heart Foundation Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College School of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, United Kingdom
    Am J Physiol Cell Physiol 282:C578-87. 2002
    ..Further elucidation of these pathways may provide important insights into innate cytoprotective mechanisms in endothelium...
  35. ncbi Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury
    Justin C Mason
    British Heart Foundation Cardiovascular Medicine Unit, National Heart and Lung Institute, Imperial College, Hammersmith Hospital, London, UK
    Circ Res 91:696-703. 2002
    ..Modulation of complement regulatory protein expression may contribute to the early beneficial effects of statins in reducing the morbidity and mortality associated with atherosclerosis...
  36. ncbi A novel model for the pre-clinical imaging of inflamed human synovial vasculature
    Toby Garrood
    William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London, UK
    Rheumatology (Oxford) 48:926-31. 2009
    ..Here we report for the first time the imaging of human synovial tissue transplanted into SCID mice using a radiolabelled anti-E-selectin antibody and NanoSPECT/CT technology...
  37. ncbi Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition
    Saifur R Ahmad
    British Heart Foundation Cardiovascular Medicine Unit, The Bywaters Centre, Imperial College London, Hammersmith Hospital, London, UK
    Immunology 110:258-68. 2003
    ..The mouse represents a suitable model for the study of novel therapeutic approaches by which vascular endothelium may be conditioned against complement-mediated injury...
  38. ncbi The role of complement in atherosclerosis
    Dorian O Haskard
    Bywaters Centre for Vascular Inflammation, National Heart and Lung Institute, Imperial College, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 19:478-82. 2008
    ..This article highlights recent publications on the complement system in the atherosclerosis field...
  39. ncbi Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages
    R Clive Landis
    British Heart Foundation Cardiovascular Medicine Unit, National Heart and Lung Institute, London, UK
    Arthritis Rheum 46:3026-33. 2002
    ..This may be of clinical relevance to the maintenance of asymptomatic hyperuricemia and the resolution of acute gout...
  40. ncbi Endothelial von Willebrand factor regulates angiogenesis
    Richard D Starke
    Cardiovascular Sciences, National Heart and Lung Institute, Faculty of Medicine, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London, London, UK
    Blood 117:1071-80. 2011
    ..These results may have important consequences for the management of VWD, with potential therapeutic implications for vascular diseases...
  41. ncbi Inflammation and tissue damage in crystal deposition diseases
    Nicola Dalbeth
    Eric Bywaters Centre, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, UK
    Curr Opin Rheumatol 17:314-8. 2005
    ..Further analysis of these responses may identify potential therapeutic targets for management of the crystal-induced arthropathies...
  42. ncbi Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis
    Miao Tzu Huang
    Imperial College, BHF Cardiovascular Sciences Unit, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Blood 106:1636-43. 2005
    ..Our findings identify a novel pathway regulating angiogenesis through ICAM-2 and a novel mechanism for Rac activation during angiogenesis...
  43. ncbi The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis
    Graeme M Birdsey
    Cardiovascular Sciences, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom
    Blood 119:894-903. 2012
    ..Thus, we have identified a novel function for the transcription factor Erg in regulating HDAC6 and multiple pathways essential for EC migration and angiogenesis...
  44. ncbi Model IgG monoclonal autoantibody-anti-idiotype pair for dissecting the humoral immune response to oxidized low density lipoprotein
    Shang Hung Chang
    1 Vascular Sciences Section, Imperial College, Hammersmith Hospital, London United Kingdom
    Hybridoma (Larchmt) 31:87-98. 2012
    ..The MAb LO1-H3 combination therefore provides a very promising model for analyzing the structure and function of an individual IgG autoantibody in relation to atherosclerosis...
  45. ncbi T lymphocyte rolling and recruitment into peripheral lymph nodes is regulated by a saturable density of L-selectin (CD62L)
    Elena Galkina
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London, UK
    Eur J Immunol 37:1243-53. 2007
    ....
  46. ncbi Clinical overview of leukocyte adhesion and migration: where are we now?
    Diane Marshall
    BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Semin Immunol 14:133-40. 2002
    ....
  47. ncbi In vivo fluorescence imaging of E-selectin: quantitative detection of endothelial activation in a mouse model of arthritis
    Luke L Gompels
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 63:107-17. 2011
    ..The purpose of this study was to demonstrate E-selectin-targeted fluorescence imaging in vivo in a mouse model of paw edema generated by local injection of TNF? as well as in mice with CIA...
  48. ncbi Enhanced recruitment of Th2 and CLA-negative lymphocytes by the S128R polymorphism of E-selectin
    Ravi M Rao
    BHF Cardiovascular Medicine Unit, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London, U K W12 0NN
    J Immunol 169:5860-5. 2002
    ..Our results demonstrate that the S128R polymorphism extends the range of lymphocytes recruited by E-selectin, which may provide a mechanistic link between this polymorphism and vascular inflammatory disease...
  49. ncbi Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice
    Vinay K Bhatia
    British Heart Foundation Cardiovascular Medicine Unit, Hammersmith Hospital, Du Cane Road, London, W12 0NN UK
    Am J Pathol 170:416-26. 2007
    ..This study suggests the importance of effective apoptotic cell removal for containing the size and complexity of early lesions in atherosclerosis...
  50. ncbi Decay-accelerating factor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-alpha/epsilon (PKCalpha/epsilon)-dependent cytoprotective signaling pathway and is i
    Justin C Mason
    British Heart Foundation Cardiovascular Medicine Unit, Eric Bywaters Center, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Biol Chem 279:41611-8. 2004
    ..This may represent an important mechanism for the maintenance of vascular integrity during chronic inflammation involving complement activation. Moreover, inhibition of this pathway by CsA may play a role in CsA-mediated vascular injury...
  51. ncbi Quantifying inflammation in vivo using radiolabeled antibodies and leukocytes
    Diane Marshall
    Celltech, Slough, UK
    Methods Mol Biol 225:273-82. 2003
  52. ncbi Knockdown of mouse VCAM-1 by vector-based siRNA
    A K M Shamsul Alam
    Department of Immunology, Division of Medicine, Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Transpl Immunol 16:185-93. 2006
    ....
  53. ncbi Detection of vascular expression of E-selectin in vivo with MR imaging
    Peter R Reynolds
    Department of Neonatal Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W121 0NN, England
    Radiology 241:469-76. 2006
    ..CONCLUSION: E-selectin expression in vivo can be selectively and directly imaged noninvasively with MR. This has the potential to be useful in the study of inflammatory disease...
  54. ncbi Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells
    Jason Partridge
    BHF Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
    FASEB J 21:3553-61. 2007
    ..Thus modulation of NF-kappaB function may underlie the atheroprotective effects of laminar shear stress...
  55. ncbi Analysis of flow-based adhesion in vitro
    Oliver Florey
    Methods Mol Med 135:323-31. 2007
    ..Dynamic flow based adhesion assay protocols build on previous static assays of leukocyte adhesion in better modeling the environment in which these interactions actually take place in vivo...
  56. ncbi Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice
    Mark C Blades
    Rheumatology Unit, Guy's, King's and St. Thomas, School of Medicine, London, United Kingdom
    J Immunol 168:4308-17. 2002
    ..This model provides a powerful tool to investigate the pathways involved in cell migration into lymphoid organs and potentially to target them for therapeutic purposes...
  57. ncbi The neutrophil: the unnoticed threat in xenotransplantation?
    Lorraine A M Cardozo
    Department of Immunology, Hammersmith Campus, Imperial College London, London, United Kingdom
    Transplantation 78:1721-8. 2004
    ..CONCLUSIONS: On the basis of these observations, we should consider the potential for neutrophil-mediated low-grade damage to xenografts emerging as a significant problem when others have been circumvented...
  58. ncbi Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration
    Benedetta Bussolati
    Department of Reproductive and Vascular Biology, The Medical School, University of Birmingham, Edgbaston, Birmingham, B12 2TG, United Kingdom
    Blood 103:761-6. 2004
    ....
  59. ncbi Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells
    Nicola Dalbeth
    University of Auckland, Grafton, Auckland, New Zealand
    Arthritis Rheum 58:1854-65. 2008
    ..To analyze cellular mechanisms of bone erosion in gout...
  60. ncbi Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering
    Aleksandar Ivetic
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS United Kingdom
    J Biol Chem 279:33263-72. 2004
    ..These results suggest that ERM proteins are required for microvillar positioning of L-selectin and that this is important both for leukocyte tethering and L-selectin shedding...
  61. ncbi Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circ Res 103:726-32. 2008
    ..We conclude that MKP-1 induction is required for the antiinflammatory effects of shear stress. Thus, our findings reveal a novel molecular mechanism contributing to the spatial distribution of vascular inflammation and atherosclerosis...
  62. ncbi Conditional immortalization of growth factor-responsive cardiac endothelial cells from H-2K(b)-tsA58 mice
    Elaine A Lidington
    British Heart Foundation Cardiovascular Medicine Unit, National Heart and Lung Institute, London, United Kingdom
    Am J Physiol Cell Physiol 282:C67-74. 2002
    ..This novel line will allow further study of the role of the endothelium in cardiovascular disease. Moreover, this technique will allow EC to be readily obtained from genetically modified mice backcrossed with H-2K(b)-tsA58 mice...
  63. ncbi L-selectin shedding does not regulate constitutive T cell trafficking but controls the migration pathways of antigen-activated T lymphocytes
    Elena Galkina
    Division of Cellular Immunology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Exp Med 198:1323-35. 2003
    ..These results suggest that the ability to shed L-selectin is not required for T cell recirculation and homing to PLNs. However, L-selectin shedding from antigen-activated T cells prevents reentry into PLNs...