I R Hart

Summary

Affiliation: Imperial Cancer Research Fund
Country: UK

Publications

  1. ncbi Perspective: tumour spread--the problems of latency
    I R Hart
    Richard Dimbleby Department of Cancer Research Imperial Cancer Research Fund, Rayne Institute, St Thomas Hospital, London, U K
    J Pathol 187:91-4. 1999
  2. ncbi The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells
    V Assmann
    Richard Dimbleby Department of Cancer Research ICRF Laboratory, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Cell Sci 111:1685-94. 1998
  3. ncbi The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments
    V Assmann
    Richard Dimbleby Department of Cancer Research ICRF Laboratory, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Cell Sci 112:3943-54. 1999
  4. ncbi The pattern of expression of the microtubule-binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cells
    V Assmann
    Richard Dimbleby Department of Cancer Research/Imperial Cancer Research Fund Laboratory, St. Thomas' Hospital, London SE1 7EH, UK
    J Pathol 195:191-6. 2001
  5. ncbi Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression
    G Francia
    Richard Dimbleby Department of Cancer Research, Rayne Institute, United Medical School, St Thomas Hospital, London, United Kingdom
    Cancer Res 56:3855-8. 1996
  6. ncbi Binding of TGF-beta1 latency-associated peptide (LAP) to alpha(v)beta6 integrin modulates behaviour of squamous carcinoma cells
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    Br J Cancer 87:859-67. 2002
  7. ncbi BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data
    P A Townsend
    Cancer Sciences Division, School of Medicine, University of Southampton, Southampton General Hospital, UK
    J Pathol 197:51-9. 2002
  8. ncbi Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    J Invest Dermatol 117:67-73. 2001
  9. ncbi Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast
    S Droufakou
    Richard Dimbleby Department of Cancer Research/Imperial Cancer Research Fund, Rayne Institute, St. Thomas' Hospital, London, United Kingdom
    Int J Cancer 92:404-8. 2001
  10. ncbi Problems with RHAMM: a new link between surface adhesion and oncogenesis?
    M Hofmann
    Forschungszentrum Karlsruhe and University of Karlsruhe, Institutes of Genetics, Germany
    Cell 95:591-2; author reply 592-3. 1998

Collaborators

  • V Assmann
  • S W Duffy
  • R Poulsom
  • R Roylance
  • J P Sleeman
  • M Hofmann
  • G J Thomas
  • R L Bowen
  • J F Marshall
  • P A Townsend
  • P M Speight
  • S Droufakou
  • J L Jones
  • A M Hanby
  • D A Ryan
  • D M Barnes
  • K Ryder
  • G Francia
  • G Packham
  • R H Kao
  • R I Cutress
  • E Dublin
  • I Tomlinson
  • V Deshmane
  • M P Lewis
  • D Sheppard
  • A Russell
  • A Hanby
  • S A Whawell
  • S D Mitchell
  • S E Moss

Detail Information

Publications11

  1. ncbi Perspective: tumour spread--the problems of latency
    I R Hart
    Richard Dimbleby Department of Cancer Research Imperial Cancer Research Fund, Rayne Institute, St Thomas Hospital, London, U K
    J Pathol 187:91-4. 1999
    ..Targeting tumour vasculature by the administration or induction of such anti-angiogenic peptides is close to clinical evaluation...
  2. ncbi The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells
    V Assmann
    Richard Dimbleby Department of Cancer Research ICRF Laboratory, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Cell Sci 111:1685-94. 1998
    ....
  3. ncbi The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments
    V Assmann
    Richard Dimbleby Department of Cancer Research ICRF Laboratory, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    J Cell Sci 112:3943-54. 1999
    ....
  4. ncbi The pattern of expression of the microtubule-binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cells
    V Assmann
    Richard Dimbleby Department of Cancer Research/Imperial Cancer Research Fund Laboratory, St. Thomas' Hospital, London SE1 7EH, UK
    J Pathol 195:191-6. 2001
    ..017). These results suggest that RHAMM/IHABP expression may contribute to the motility and invasiveness of a tumour cell sub-population in breast cancers...
  5. ncbi Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression
    G Francia
    Richard Dimbleby Department of Cancer Research, Rayne Institute, United Medical School, St Thomas Hospital, London, United Kingdom
    Cancer Res 56:3855-8. 1996
    ..Our results provide further evidence for a potential role of Annexin VI in tumor suppression...
  6. ncbi Binding of TGF-beta1 latency-associated peptide (LAP) to alpha(v)beta6 integrin modulates behaviour of squamous carcinoma cells
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    Br J Cancer 87:859-67. 2002
    ....
  7. ncbi BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data
    P A Townsend
    Cancer Sciences Division, School of Medicine, University of Southampton, Southampton General Hospital, UK
    J Pathol 197:51-9. 2002
    ..These results are consistent with the hypothesis that BAG-1 plays an important but variable role in breast cancers developing in pre-menopausal and post-menopausal women...
  8. ncbi Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    J Invest Dermatol 117:67-73. 2001
    ..alphavbeta6 expression may have a significant role in contributing to the malignant behavior of epithelial cells...
  9. ncbi Multiple ways of silencing E-cadherin gene expression in lobular carcinoma of the breast
    S Droufakou
    Richard Dimbleby Department of Cancer Research/Imperial Cancer Research Fund, Rayne Institute, St. Thomas' Hospital, London, United Kingdom
    Int J Cancer 92:404-8. 2001
    ..In all cases in which there was loss of expression, this was consistent with biallelic inactivation of CDH1 by promoter methylation, mutation or allelic loss in any combination...
  10. ncbi Problems with RHAMM: a new link between surface adhesion and oncogenesis?
    M Hofmann
    Forschungszentrum Karlsruhe and University of Karlsruhe, Institutes of Genetics, Germany
    Cell 95:591-2; author reply 592-3. 1998
  11. ncbi Early onset of breast cancer in a group of British black women
    R L Bowen
    Centre for Tumour Biology, Institute of Cancer and CR UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    Br J Cancer 98:277-81. 2008
    ..There were no disparities in socioeconomic status or treatment received. Our findings could have major implications for the biology of breast cancer and the detection and treatment of the disease in black women...