Research Topics
| Stuart J ForbesSummaryAffiliation: Imperial College Country: UK Publications
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Detail Information
Publications
The bone marrow functionally contributes to liver fibrosisFrancesco P Russo
Department of Medicine, Imperial College, London, United Kingdom
Gastroenterology 130:1807-21. 2006..Clinical trials of BM cell therapy for liver regeneration should be vigilant for the possibility of enhanced organ fibrosis...- Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted miceNatalie C Direkze
Histopathology Unit, Cancer Research UK London Research Institute, London, United Kingdom
Stem Cells 21:514-20. 2003..005). Bone-marrow-derived fibroblasts were also found. We suggest that bone marrow contributes to a circulating population of cells and, in the context of injury, these cells are recruited and contribute to tissue repair... - A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosisStuart J Forbes
Hepatology Section, Department of Medicine, Imperial College, London, England
Gastroenterology 126:955-63. 2004.... - Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell responseYiannis N Kallis
Department of Medicine, St Mary s Hospital Campus, Imperial College London, London, UK
Gut 60:525-33. 2011.... - Bone marrow cells in the liver: diverse cells, diverse effectsFrancesco P Russo
Hepatology 46:604-5; author reply 605-6. 2007 - Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signalingDavid C Hay
Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
Proc Natl Acad Sci U S A 105:12301-6. 2008..These studies represent an important step toward the use of hESC-derived hepatocytes in high-throughput metabolic analysis of human liver function... - Regulation of alternative macrophage activation by galectin-3Alison C Mackinnon
Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
J Immunol 180:2650-8. 2008..Pharmacological modulation of galectin-3 function represents a novel therapeutic strategy in pathologies associated with alternatively activated macrophages... - Progenitor cell characterization and location in the developing human liverJohn D Terrace
Centre for Regenerative Medicine, University of Edinburgh Medical School, EH16 4SB, Edinburgh, United Kingdom
Stem Cells Dev 16:771-8. 2007..Therefore, this structure may constitute a novel progenitor compartment with hemangioblast-like properties... - The sources of parenchymal regeneration after chronic hepatocellular liver injury in micePamela Vig
Hepatology Section, Imperial College London, United Kingdom
Hepatology 43:316-24. 2006..In conclusion, during regenerative stress, the contribution to parenchymal regeneration from the BM is minor and frequently attributable to cell fusion. OCs and SHPCs are of intrinsic hepatic origin, and OCs can form SHPC nodules... - Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X proteinVictor V Keasler
Department of Molecular Virology and Microbiology, Baylor College of Medicine (BCM-385, One Baylor Plaza, Houston, TX 77030-3411, USA
Virology 347:466-75. 2006..These results indicate that HBx expression contributes to increased liver pathogenesis in HCV transgenic mice by a mechanism that involves an imbalance in hepatocyte death and regeneration within the context of severe steatosis... - Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repairJeremy S Duffield
Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
J Clin Invest 115:56-65. 2005..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring... - Bone marrow-derived liver stem cells: their therapeutic potentialStuart J Forbes
Gastroenterology 123:654-5. 2002 - Adult stem cell plasticityRichard Poulsom
Histopathology Unit, Cancer Research UK, London Research Institute, London, UK
J Pathol 197:441-56. 2002..This article reviews some of the evidence for stem cell plasticity in rodents and man...