Research Topics
Genomes and Genes
| C DicksonSummaryAffiliation: Imperial Cancer Research Fund Country: UK Publications
| Collaborators
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Detail Information
Publications
Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptorsC Dickson
Imperial Cancer Research Fund, London, UK
Breast Cancer Res 2:191-6. 2000..Although examination of human breast cancers has shown an altered expression of FGFs or of their receptors in some tumours, their role in the causation of breast disease is unclear and remains controversial...- An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesisL De Moerlooze
Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, UK
Development 127:483-92. 2000..Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis... - Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIbJ M Revest
Imperial Cancer Research Fund, London, UK
J Immunol 167:1954-61. 2001..Nevertheless, sufficient epithelial cell differentiation occurs in the severely hypoplastic thymus to allow the development of CD4/CD8-double-positive thymocytes and a very small number of single-positive thymocytes expressing TCRs... - Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4J M Revest
Imperial Cancer Research Fund, Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
Dev Biol 231:47-62. 2001..5, providing evidence that Fgfs act primarily as survival factors. We propose that FgfR2-IIIb is not required for limb bud initiation, but is essential for its maintenance and growth... - Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary glandD Jackson
Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, London, UK
J Cell Sci 110:1261-8. 1997..These findings demonstrate that fibroblast growth factor signalling is necessary for pregnancy dependent lobuloalveolar development of the mammary gland... - Secretion and mitogenic activity of zebrafish FGF3 reveal intermediate properties relative to mouse and Xenopus homologuesP Kiefer
Imperial Cancer Research Fund Laboratories, London, UK
Oncogene 12:1503-11. 1996..Thus, ZFGF3 shows the structural and secretory properties of XFGF3, but has biological properties more akin to those of the mouse homologue... - FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactionsI J Mason
Division of Anatomy and Cell Biology, U M D S Guy s Hospital, London, UK
Mech Dev 45:15-30. 1994..Our results suggest that FGF-7 is likely to have diverse roles during development... - The mouse homologue of hst/k-FGF: sequence, genome organization and location relative to int-2S Brookes
Imperial Cancer Research Fund Laboratories, St Bartholomew s Hospital, London, UK
Nucleic Acids Res 17:4037-45. 1989..Translation of the major open reading frame would yield a 202 amino acid protein that is 82% homologous to human HST but lacking 4 residues at the presumed signal peptide cleavage site... - Mice lacking cyclin D1 are small and show defects in eye and mammary gland developmentV Fantl
Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund ICRF, London, UK
Genes Dev 9:2364-72. 1995..Thus although cyclin D1 kinase activity may facilitate G1 progression, it is not essential for the development of most tissues and organs, and only a few specialized cell lineages are demonstrably sensitive to its absence... - Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomousV Fantl
Viral Carcinogenesis Laboratory, Histopathology Unit, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
Dev Biol 212:1-11. 1999.... - Multiple roles for FGF-3 during cranial neural development in the chickenR Mahmood
MRC Brain Development Programme, UMDS Guy s Hospital, London, UK
Development 121:1399-410. 1995..Expression was also detected in the segmental plate and in the posterior half of the three most-recently generated somites... - Mouse mammary-tumor virus activates Fgf-3/Int-2 less frequently in tumors from virgin than from parous miceN Clausse
Imperial Cancer Research Fund Laboratories, London, UK
Int J Cancer 55:157-63. 1993..These data strengthen the link between Fgf-3 and a pregnancy-dependent phenotype and suggest that, in the strains analyzed, the frequency of Int-gene activation was influenced more by the hormonal status than by the genetic background... - Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factorsR Smith
Imperial Cancer Research Fund Laboratories, London, UK
EMBO J 7:1013-22. 1988.... - A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypesM K Hajihosseini
Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Proc Natl Acad Sci U S A 98:3855-60. 2001..This phenotype has strong parallels to some Apert's and Pfeiffer's syndrome patients... - Characterization of int-2: a member of the fibroblast growth factor familyC Dickson
Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, Lincoln s Inn Fields, London, UK
J Cell Sci Suppl 13:87-96. 1990..These findings suggest the potential for a dual role of int-2; an autocrine function acting at the cell nucleus, and a possible paracrine action through a secreted product... - Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell linesI Palmero
Imperial Cancer Research Fund Laboratories, London, UK
Oncogene 8:1049-54. 1993..The data imply that the D-type cyclins may have non-overlapping functions at specific stages of lymphocyte differentiation and that the expression of cyclin D2 may be influenced, directly or indirectly, by EBV... - CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1S Bates
Imperial Cancer Research Fund Laboratories, London, UK
Oncogene 9:71-9. 1994..The data suggest that D-type cyclins participate in multiple interactions with CDKs but that the nature or stoichiometry of these associations may differ in different types of cell... - FGF3 from Xenopus laevisP Kiefer
Imperial Cancer Research Fund, London, UK
EMBO J 12:4159-68. 1993..Increasing the contribution from mouse FGF3 led to a more restricted host range for the chimeric ligand... - Sequence organization of the human int-2 gene and its expression in teratocarcinoma cellsS Brookes
Imperial Cancer Research Fund Laboratories, St Bartholomew s Hospital, London, UK
Oncogene 4:429-36. 1989..This divergence occurs distal to the region of int-2 that shows homology to other members of the FGF family of growth modulators and oncogenes... - Fibroblast growth factor signalling in mouse mammary gland developmentB Spencer-Dene
Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
Endocr Relat Cancer 8:211-7. 2001.... - A subset of fibroblast growth factors (Fgfs) promote survival, but Fgf-8b specifically promotes astroglial differentiation of rat cortical precursor cellsM K Hajihosseini
Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, London, United Kingdom
Mol Cell Neurosci 14:468-85. 1999..These studies demonstrate that cortical precursor cells respond to Fgf stimulation in different ways depending on the ligand and by inference the Fgf receptors activated... - Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1S Brookes
Imperial Cancer Research Fund Laboratory, Lincoln s Inn Fields, London, United Kingdom
Genes Chromosomes Cancer 6:222-31. 1993..EMS1 and CCND1 (formerly PRAD1), the best candidates for the key gene on the 11q13 amplicon, are > or = 800 kb apart... - Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouseD G Wilkinson
Laboratory of Developmental Biochemistry, National Institute for Medical Research, Mill Hill, London, UK
EMBO J 7:691-5. 1988..The data suggest multiple roles for int-2 in development which may include migration of early mesoderm cells and induction of the otocyst... - Cell transformation by kFGF requires secretion but not glycosylationF Fuller-Pace
Imperial Cancer Research Fund Laboratories, Lincoln s Inn Fields, London, United Kingdom
J Cell Biol 115:547-55. 1991.... - Skeletal disorders associated with fibroblast growth factor receptor mutationsL De Moerlooze
Imperial Cancer Research Fund, London, UK
Curr Opin Genet Dev 7:378-85. 1997..A functional analysis of several of these mutations has demonstrated that a constitutive activation of the receptor kinase is a common theme... - A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowthR Mahmood
Division of Anatomy and Cell Biology, UMDS Guy s Hospital, London, UK
Curr Biol 5:797-806. 1995..Likewise, the other FGFs studied to date are not candidates for this activity... - Proviral insertions near cyclin D1 in mouse lymphomas: a parallel for BCL1 translocations in human B-cell neoplasmsG A Lammie
Molecular Oncology Laboratory, Imperial Cancer Research Fund, London, UK
Oncogene 7:2381-7. 1992..The data suggest that proviral insertions near Cyl-1 in mouse lymphomas are functionally equivalent to the BCL1 translocations that activate cyclin D1 expression in human B-cell malignancies... - Nonuniform expression of a mouse mammary tumor virus-driven int-2/Fgf-3 transgene in pregnancy-responsive breast tumorsG Stamp
Histopathology Laboratory, Imperial Cancer Research Fund, London, United Kingdom
Cell Growth Differ 3:929-38. 1992.... - FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesisU Pirvola
Institute of Biotechnology and Department of Otorhinolaryngology, University of Helsinki, 00014 Helsinki, Finland
J Neurosci 20:6125-34. 2000..Our findings provide genetic evidence that signaling by FGFR-2(IIIb) is critical for the morphological development of the inner ear... - Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs that is preferentially expressed in the skin and the brainH D Beer
Institute of Cell Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
J Biol Chem 275:16091-7. 2000.... - Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouseR C Burns
Division of Developmental Biology, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
Dev Biol 265:61-74. 2004..Thus, FGF10 signaling via FGFR2b appears to be critical in the extension of the epithelium into the mesenchyme during cecal development... - Genomic organization of the mouse cyclin D1 gene (Cyl-1)R Smith
Imperial Cancer Research Fund Laboratories, London, United Kingdom
Genomics 25:85-92. 1995..However, hybridization with specific probes revealed that the minor transcript lacks approximately 800 nucleotides from the 3' end of the major transcript and may be generated by a novel mechanism or by RNA processing... - Differential cyclin D1 requirements of proliferating Schwann cells during development and after injuryS Atanasoski
Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, , CH-8093 Zurich, Switzerland
Mol Cell Neurosci 18:581-92. 2001..Thus, our data indicate that the molecular mechanisms regulating proliferation of Schwann cells during development or activated by axonal damage are fundamentally different... - Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signalingL E Reynolds
Cell Adhesion and Disease Laboratory, Department of Tumour Biology, Cancer Research UK, Bart s and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
Nat Med 11:167-74. 2005..These data indicate that alpha(v)beta(3)-integrin can suppress TGF-beta1-mediated signaling, thereby controlling the rate of wound healing, and highlight a new mechanism for TGF-beta1 regulation by beta(3)-integrins...