Research Topics
Genomes and Genes | Andrew P CopeSummaryAffiliation: Imperial College Country: UK Publications
| Collaborators
|
Detail Information
Publications
22nd European Workshop for Rheumatology Research, Leiden, The Netherlands, 28 February-3 March 2002Andrew P Cope
The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Hammersmith, London, UK
Arthritis Res 4:276-9. 2002..Opportunities for exploring whether pharmacogenomics has a place in the clinic are now a reality, and phage display technology has been applied to in vivo arthritis models to identify human synovial microvascular 'post codes'...- Studies of T-cell activation in chronic inflammationAndrew P Cope
The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
Arthritis Res 4:S197-211. 2002.... - Tracking antigen-experienced effector T cells in vitro and in vivoClaire L Gorman
Faculty of Medicine, Imperial College London, The Kennedy Institute of Rheumatology, London, UK
Methods Mol Biol 616:253-67. 2010.... - Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controlsClaire L Gorman
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, UK
J Immunol 180:1060-70. 2008..033). This suggests that a genetically determined reduction in TCRzeta expression has functional consequences manifested by systemic autoimmunity... - Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine productionMatthew J Peirce
Kennedy Institute of Rheumatology Division, Imperial College London, London, UK
PLoS ONE 5:e11465. 2010.... - Proteomic analysis of the lymphocyte plasma membrane using cell surface biotinylation and solution-phase isoelectric focusingMatthew J Peirce
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK
Methods Mol Biol 528:135-40. 2009..We discuss the application of this protocol to the semiquantitative comparison of the plasma membrane proteins from resting and activated murine lymphocytes... - Immune-mediated pathways in chronic inflammatory arthritisClaire L Gorman
The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
Best Pract Res Clin Rheumatol 22:221-38. 2008..Over recent years, a number of crucial advances in our understanding of the disease have had a major impact on the treatment of patients with RA... - TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissuesZhuoli Zhang
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, Hammersmith, London, United Kingdom
Blood 109:4328-35. 2007..Taken together, the functional properties of TCRzeta(dim) T cells make them promising cellular targets for the treatment of chronic inflammatory disease... - Harmful waste products as novel immune modulators for treating inflammatory arthritis?Andrew P Cope
Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, United Kingdom
PLoS Med 3:e385. 2006 - T cells in rheumatoid arthritisAndrew P Cope
The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Aspenlea Road, Hammersmith, London, W6 8LH, UK
Arthritis Res Ther 10:S1. 2008..This review summarizes current perspectives on RA disease pathogenesis, with particular emphasis on what RA T cells look like, what they are likely to see, and how they contribute to persistence of the chronic inflammatory response... - Rheumatoid arthritis: a disease of chronic, low-amplitude signals transduced through T cell antigen receptors?Zhuoli Zhang
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom
Wien Med Wochenschr 156:2-10. 2006.... - Two-stage affinity purification for inducibly phosphorylated membrane proteinsMatthew J Peirce
Kennedy Institute of Rheumatology Division, Imperial College, London, UK
Proteomics 5:2417-21. 2005.... - Emerging approaches for the therapy of autoimmune and chronic inflammatory diseaseAndrew P Cope
The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
Curr Opin Immunol 16:780-6. 2004..It is our belief that the future of immunotherapy in the clinic will depend to some extent upon the availability of biomarkers for defining biological signatures of immune function in vivo... - T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alphaJoanna M Clark
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, United Kingdom
Proc Natl Acad Sci U S A 101:1696-701. 2004..We provide additional evidence that TNF also uncouples distal TCR signaling pathways independently of its effects on TCRzeta expression... - Altered signalling thresholds in T lymphocytes cause autoimmune arthritisAndrew P Cope
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK
Arthritis Res Ther 6:112-6. 2004..They will also provide unique tools for dissecting precisely how chronically activated T cells contribute to the effector phase of arthritis through mechanisms that may be less dependent on antigen receptor signalling... - Pathways of T cell activation and terminal differentiation in chronic inflammationPia Isomäki
Institute of Medical Technology, Tampere University and Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Curr Drug Targets Inflamm Allergy 4:287-93. 2005..The possible implications of this inbalance are discussed... - Nitric oxide, chronic inflammation and autoimmunityGyorgy Nagy
Department of Rheumatology, Semmelweis University, Medical School, Arpád fejedelem u 7, 1023 Budapest, Hungary
Immunol Lett 111:1-5. 2007.... - Mapping lymphocyte plasma membrane proteins: a proteomic approachMatthew J Peirce
Kennedy Institute of Rheumatology Division, Imperial College London, UK
Methods Mol Med 136:361-7. 2007..The method is applicable to a wide variety of cell types... - Expression profiling of lymphocyte plasma membrane proteinsMatthew J Peirce
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London W6 8LH, United Kingdom
Mol Cell Proteomics 3:56-65. 2004..This approach offers a generic and powerful strategy for investigating differential expression of surface proteins in many cell types under varying environmental and pathophysiological conditions... - Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cellsAthanasios Mavropoulos
Kennedy Institute of Rheumatology Division, Imperial College London, London, United Kingdom
Blood 105:282-8. 2005..Therefore, the synergistic induction of IFN-gamma by IL-12 and IL-18 in natural killer cells is mediated at least in part by p38-dependent and 3' UTR-mediated stabilization of IFN-gamma mRNA... - Nitric oxide production of T lymphocytes is increased in rheumatoid arthritisGyorgy Nagy
Department of Rheumatology, Semmelweis University, Medical School, Budapest, Hungary
Immunol Lett 118:55-8. 2008..005). Together, these data indicate that TNF induced NO production in T lymphocytes may contribute to perturbations of immune homeostasis in RA... - The role of tumour necrosis factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU)Andrew D Dick
Department of Clinical Sciences at South Bristol, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
Prog Retin Eye Res 23:617-37. 2004.... - Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexesFrances C Hall
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
Eur J Immunol 32:662-70. 2002..These data indicate that kinetic stability of peptide/MHC complexes in vivo is a key determinant of immunogenicity...