Research Topics
Genomes and GenesSpecies | Jacob G BundySummaryAffiliation: Imperial College Country: UK Publications
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Publications
Environmental metabonomics: applying combination biomarker analysis in earthworms at a metal contaminated siteJacob G Bundy
Biological Chemistry, Biomedical Sciences Division, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, London SW7 2AZ, UK
Ecotoxicology 13:797-806. 2004..terrestris. This study demonstrates the utility of NMR spectroscopy in detecting previously unknown potential biomarkers for ecotoxicity testing and identified maltose as a potential biomarker compound deserving of further study...- The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strainsLisa F Dawson
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
BMC Microbiol 11:86. 2011..It has been proposed that the hpdBCA operon, rarely found in other gut microflora, encodes the enzymes responsible for the conversion of p-HPA to p-cresol... - 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellusJacob G Bundy
Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology, and Anaesthetics, Faculty of Medicine, Imperial College London, SW7 2AZ, London, UK
BMC Biol 6:25. 2008.... - Metabolic profile biomarkers of metal contamination in a sentinel terrestrial species are applicable across multiple sitesJacob G Bundy
Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ
Environ Sci Technol 41:4458-64. 2007..This study therefore acts as a proof of principle for the use of NMR-based metabolic profiling as a diagnostic tool for ecotoxicological research in polluted field soils... - Metabonomic assessment of toxicity of 4-fluoroaniline, 3,5-difluoroaniline and 2-fluoro-4-methylaniline to the earthworm Eisenia veneta (Rosa): identification of new endogenous biomarkersJacob G Bundy
Imperial College of Science, Technology and Medicine, Biological Chemistry, Faculty of Medicine, South Kensington, London, United Kingdom
Environ Toxicol Chem 21:1966-72. 2002..These changes could potentially be used as novel biomarkers of xenobiotic toxicity and could be used to determine the mechanism of action of other toxic chemicals... - Between-person comparison of metabolite fitting for NMR-based quantitative metabolomicsGregory D Tredwell
Department of Surgery and Cancer, Imperial College London, London, UK
Anal Chem 83:8683-7. 2011..Overall, the effect of the person was less than the experimental group (in this case, sampling method) for almost all of the metabolites... - C. elegans metallothioneins: response to and defence against ROS toxicitySukaina Zeitoun-Ghandour
King s College London, School of Biomedical Sciences, Pharmaceutical Science Division, London, UK
Mol Biosyst 7:2397-406. 2011..In summary, this study highlights that C. elegans metallothioneins scavenge and protect against reactive oxygen species and potentially against oxidative stress, with CeMT-2 being more effective than CeMT-1... - Cross-platform comparison of Caenorhabditis elegans tissue extraction strategies for comprehensive metabolome coverageFlorian M Geier
Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, South Kensington, SW7 2AZ, United Kingdom
Anal Chem 83:3730-6. 2011.... - Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegansSarah K Davies
Department of Life Sciences, Imperial College London, London, UK
Mech Ageing Dev 133:46-9. 2012..This indicates that FUdR should only be used with caution for C. elegans ageing experiments, and should not be assumed to be independent of other factors being studied... - A software complement to AMDIS for processing GC-MS metabolomic dataVolker Behrends
Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
Anal Biochem 415:206-8. 2011..The freely available package runs within the commercial Matlab environment and is useful where GC-MS is used to profile complex mixtures... - Metabolic profiling of Pseudomonas aeruginosa demonstrates that the anti-sigma factor MucA modulates osmotic stress toleranceVolker Behrends
Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK SW7 2AZ
Mol Biosyst 6:562-9. 2010.... - Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profilingJacob G Bundy
Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, UK
FEBS Lett 521:115-20. 2002..fetida and E. andrei) differ markedly in their biochemical profiles despite apparently occupying the same ecological niche, and indicate that metabolic phenotype profiling can be used as a powerful functional genomics tool... - Multivariate metabolic profiling using 1H nuclear magnetic resonance spectroscopy of freeze-tolerant and freeze-intolerant earthworms exposed to frostJacob G Bundy
Biological Chemistry, Imperial College of Science, Technology and Medicine, Division of Biomedical Sciences, Faculty of Medicine, Sir Alexander Fleming Building, London SW7 2AZ, UK
Cryo Letters 24:347-58. 2003..octaedra. Furthermore there was no lactate accumulation in D. octaedra, whereas three of the other four species accumulated lactate. This indicates that anoxic metabolism was lowest in the freeze-tolerant species... - A metabolic signature of long life in Caenorhabditis elegansSilke Fuchs
Division of Biology, Silwood Park Campus, Imperial College London, UK
BMC Biol 8:14. 2010..Here we use one of these, 1H nuclear magnetic resonance spectroscopy, to investigate what makes long-lived worms metabolically distinctive... - The development of metabolomic sampling procedures for Pichia pastoris, and baseline metabolome dataGregory D Tredwell
Department of Surgery and Cancer, Imperial College London, London, United Kingdom
PLoS ONE 6:e16286. 2011..pastoris for future studies. The P. pastoris metabolome is significantly different from that of Saccharomyces cerevisiae, with the most notable difference being the production of high concentrations of arabitol by P. pastoris... - Time-resolved metabolic footprinting for nonlinear modeling of bacterial substrate utilizationVolker Behrends
Imperial College London, Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology, and Anaesthetics, Faculty of Medicine, Sir Alexander Fleming Building, London SW7 2AZ, United Kingdom
Appl Environ Microbiol 75:2453-63. 2009..We believe time-resolved metabolic footprinting could be a valuable tool for many questions in bacteriology, including isolate comparisons, phenotyping deletion mutants, and as a functional complement to taxonomic classifications... - Investigation of the physiological relationship between the cyanide-insensitive oxidase and cyanide production in Pseudomonas aeruginosaJames E A Zlosnik
Division of Biology, Faculty of Natural Sciences, Imperial College London, Sir Alexander Fleming Building, London SW7 2AZ, UK
Microbiology 152:1407-15. 2006..The CIO mutant had delayed killing kinetics, demonstrating that the CIO is required for full pathogenicity of P. aeruginosa in this animal model... - The cellular geometry of growth drives the amino acid economy of Caenorhabditis elegansJonathan Swire
Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK
Proc Biol Sci 276:2747-54. 2009..We expect these relations to be universal in single cells and in whole multicellular organisms that grow largely by increases in cell size, but not those that grow by cell proliferation... - Establishing principal soil quality parameters influencing earthworms in urban soils using bioassaysPeter K Hankard
Centre for Ecology and Hydrology, Monks Wood, Abbots Ripton, Huntingdon PE28 2LS, UK
Environ Pollut 133:199-211. 2005..We thus conclude that chemical analysis alone is not sufficient to characterize soil quality and confirms the value of biological assays for risk assessment of potentially contaminated soils... - Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profilingJacob G Bundy
Department of Biochemistry, University of Cambridge, Cambridge, UK
Genome Res 17:510-9. 2007.... - Discrimination of pathogenic clinical isolates and laboratory strains of Bacillus cereus by NMR-based metabolomic profilingJacob G Bundy
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
FEMS Microbiol Lett 242:127-36. 2005.... - Metabolomic profiling of rapid cold hardening and cold shock in Drosophila melanogasterJohannes Overgaard
National Environmental Research Institute, University of Aarhus, Department of Terrestrial Ecology, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
J Insect Physiol 53:1218-32. 2007..These findings suggest a putative role of cryoprotectants during RCH which are discussed in the light of the existing literature on the mechanistic background of RCH...