M Bower

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Current issues in the biology of AIDS-related lymphoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    HIV Med 2:141-5. 2001
  2. ncbi Weekly alternating combination chemotherapy for good prognosis AIDS-related lymphoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    Eur J Cancer 36:363-7. 2000
  3. ncbi AIDS-associated malignancies
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Cancer Chemother Biol Response Modif 22:687-706. 2005
  4. ncbi AIDS-related malignancies: changing epidemiology and the impact of highly active antiretroviral therapy
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Curr Opin Infect Dis 19:14-9. 2006
  5. ncbi Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    J Clin Oncol 23:5224-8. 2005
  6. ncbi HIV-related lung cancer in the era of highly active antiretroviral therapy
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    AIDS 17:371-5. 2003
  7. ncbi HIV-associated anal cancer: has highly active antiretroviral therapy reduced the incidence or improved the outcome?
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1563-5. 2004
  8. ncbi Pulmonary Kaposi sarcoma in the era of highly active antiretroviral therapy
    C Palmieri
    Department of Medical Oncology, The Chelsea and Westminster Hospital, London, UK
    HIV Med 7:291-3. 2006
  9. ncbi Assessment of the efficacy of total lymphocyte counts as predictors of AIDS defining infections in HIV-1 infected people
    J Stebbing
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    Postgrad Med J 81:586-8. 2005
  10. ncbi Absence of association between individual thymidine analogues or nonnucleoside analogues and lipid abnormalities in HIV-1-infected persons on initial therapy
    G V Matthews
    Chelsea and Westminster Hospital, London, U K
    J Acquir Immune Defic Syndr 24:310-5. 2000

Detail Information

Publications112 found, 100 shown here

  1. ncbi Current issues in the biology of AIDS-related lymphoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    HIV Med 2:141-5. 2001
    ..These topics are covered in this article and their potential application to the clinical management of AIDS-related lymphomas are discussed...
  2. ncbi Weekly alternating combination chemotherapy for good prognosis AIDS-related lymphoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London, UK
    Eur J Cancer 36:363-7. 2000
    ..For selected patients with good prognosis ARL 12 weeks BEMOP/CA therapy produces good overall survival at 2 years...
  3. ncbi AIDS-associated malignancies
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Cancer Chemother Biol Response Modif 22:687-706. 2005
  4. ncbi AIDS-related malignancies: changing epidemiology and the impact of highly active antiretroviral therapy
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    Curr Opin Infect Dis 19:14-9. 2006
    ..This review discusses the impact of highly active antiretroviral therapy on the epidemiology and outcome of AIDS-defining cancers...
  5. ncbi Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    J Clin Oncol 23:5224-8. 2005
    ..This clinical response, known as the immune reconstitution inflammatory syndrome (IRIS), occurs secondary to an immune response against previously diagnosed pathogens...
  6. ncbi HIV-related lung cancer in the era of highly active antiretroviral therapy
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    AIDS 17:371-5. 2003
    ..To address the impact of highly active antiretroviral therapy (HAART) on the incidence and outcome of patients with HIV-related lung cancer...
  7. ncbi HIV-associated anal cancer: has highly active antiretroviral therapy reduced the incidence or improved the outcome?
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1563-5. 2004
    ..We wished to evaluate its effects on incidence and survival in HIV-associated anal cancer...
  8. ncbi Pulmonary Kaposi sarcoma in the era of highly active antiretroviral therapy
    C Palmieri
    Department of Medical Oncology, The Chelsea and Westminster Hospital, London, UK
    HIV Med 7:291-3. 2006
    ..0001). CONCLUSION: PKS remains an ominous diagnosis in the era of HAART, with a median survival of just 1.6 years...
  9. ncbi Assessment of the efficacy of total lymphocyte counts as predictors of AIDS defining infections in HIV-1 infected people
    J Stebbing
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK
    Postgrad Med J 81:586-8. 2005
    ..This study assessed the utility of the total lymphocyte count (TLC) in place of the CD4 count to predict the development of AIDS defining opportunistic infections (ADOI)...
  10. ncbi Absence of association between individual thymidine analogues or nonnucleoside analogues and lipid abnormalities in HIV-1-infected persons on initial therapy
    G V Matthews
    Chelsea and Westminster Hospital, London, U K
    J Acquir Immune Defic Syndr 24:310-5. 2000
    ..In conclusion, no differences were observed between choice of drug or combination on cholesterol or triglyceride values during therapy. Older individuals may be more likely to have elevated cholesterol values...
  11. ncbi Impact of antiretroviral choice on hypercholesterolaemia events: the role of the nucleoside reverse transcriptase inhibitor backbone
    R Jones
    Department of HIV and GU Medicine, The Chelsea and Westminster Hospital, London, UK
    HIV Med 6:396-402. 2005
    ..Metabolic abnormalities associated with antiretrovirals and cumulative exposure to combination antiretroviral therapy, including dyslipidaemia and insulin resistance, have been linked to an increased risk of myocardial infarction...
  12. ncbi Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi's sarcoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    AIDS 13:2105-11. 1999
    ..To evaluate the impact of highly active antiretroviral therapy (HAART) on Kaposi's sarcoma...
  13. ncbi Outcome of patients with HIV-related germ cell tumours: a case-control study
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
    Br J Cancer 90:1526-30. 2004
    ..78). The overall survival has not improved since the introduction of highly active antiretroviral therapy (log rank P=0.4). Thus, HIV-related GCT is not more aggressive than GCT in the general population...
  14. ncbi Highly active anti-retroviral therapy (HAART)-induced maintenance of adaptive but not innate immune parameters is associated with protection from HIV-induced mortality
    J Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Clin Exp Immunol 145:271-6. 2006
    ..001). Effective HAART-induced maintenance of the adaptive immune system (CD4, CD8 and CD19 counts) protects from HIV-related mortality...
  15. ncbi The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily
    M Y Tung
    St Stephens Centre, Chelsea and Westminster Hospital, London, UK
    HIV Med 6:151-4. 2005
    ..Low-dose ddI 250 mg once daily plus TDF as part of antiretroviral therapy was effective...
  16. ncbi EMA/CO for high-risk gestational trophoblastic tumors: results from a cohort of 272 patients
    M Bower
    Medical Oncology Unit, Charing Cross Hospital, London, United Kingdom
    J Clin Oncol 15:2636-43. 1997
    ....
  17. ncbi The successful treatment of haemophagocytic syndrome in patients with human immunodeficiency virus-associated multi-centric Castleman's disease
    J Stebbing
    Department of Oncology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London UK
    Clin Exp Immunol 154:399-405. 2008
    ..Systemic activation of cytokines was limited, suggesting that immunosuppressive therapy with steroids is not indicated in HHV-8-driven HPS...
  18. ncbi Multicenter study of human immunodeficiency virus-related germ cell tumors
    T Powles
    Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 21:1922-7. 2003
    ..After a median follow-up of 4.6 years, 9% of the patients died from GCT. Most of the mortality relates to HIV infection...
  19. ncbi The role of immune suppression and HHV-8 in the increasing incidence of HIV-associated multicentric Castleman's disease
    T Powles
    Department of Medical Oncology, Barts and the London Medical School, London, UK
    Ann Oncol 20:775-9. 2009
    ..In HIV cohorts with access to highly active antiretroviral therapy (HAART), the incidence of Kaposi's sarcoma (KS) is falling; however, the incidence of multicentric Castleman's disease (MCD) in HIV has not previously been described...
  20. ncbi Head and neck cancer in patients with human immunodeficiency virus-1 infection: incidence, outcome and association with Epstein-Barr virus
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    J Laryngol Otol 118:207-12. 2004
    ..All but one of the patients died of cancer with a median survival of 28 months. Head and neck cancer occurs more frequently in HIV. It is an aggressive disease and EBV may play a role in its pathogenesis...
  21. ncbi A comparison of the CD4 response to antiretroviral regimens in patients commencing therapy with low CD4 counts
    L Waters
    St Stephen s Centre, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    J Antimicrob Chemother 54:503-7. 2004
    ..To compare the immunological response to highly active antiretroviral therapy (HAART) in treatment-naive patients with a baseline CD4 count of <200 cells/mm(3)...
  22. ncbi A single centre cohort experience with a new once daily antiretroviral drug
    J Stebbing
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK
    Postgrad Med J 82:343-6. 2006
    ..CONCLUSIONS: These data should provide reassurance for clinicians wishing to introduce a new antiretroviral into an established cohort...
  23. ncbi A comparison of patients with relapsed and chemo-refractory gestational trophoblastic neoplasia
    T Powles
    Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Hammersmith Hospitals Campus of Imperial College London, London, UK
    Br J Cancer 96:732-7. 2007
    ..01)). The outcome of patients with relapsed GTN is good. However, patients with primary chemo-refractory disease do poorly and novel therapies are required for this group of patients...
  24. ncbi Programmed death (PD)-1 molecule and its ligand PD-L1 distribution among memory CD4 and CD8 T cell subsets in human immunodeficiency virus-1-infected individuals
    G Rosignoli
    Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 157:90-7. 2009
    ....
  25. ncbi AIDS-related non-Hodgkin's lymphoma in the first decade of highly active antiretroviral therapy
    C Palmieri
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    QJM 99:811-26. 2006
    ..In the era of HAART, the goal of therapy for these patients is now complete remission rather than palliation...
  26. ncbi Paclitaxel for anthracycline-resistant AIDS-related Kaposi's sarcoma: clinical and angiogenic correlations
    J Stebbing
    Departments of Oncology and HIV Medicine, Chelsea and Westminster Hospital, London, UK
    Ann Oncol 14:1660-6. 2003
    ..Overall, clinical response in KS correlates poorly with known angiogenic cytokines...
  27. ncbi Immune reconstitution inflammatory syndrome mimicking relapse of AIDS related lymphoma in patients with HIV 1 infection
    T Powles
    Departments of Oncology and HIV Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Leuk Lymphoma 44:1417-9. 2003
    ..We present three cases of IRIS following a diagnosis of AIDS related non-Hodgkin's lymphoma that resembled lymphoma relapse...
  28. ncbi Pneumonia due to antibiotic resistant Streptococcus pneumoniae and Pseudomonas aeruginosa in the HAART era
    S H Allen
    Department of Microbiology, Chelsea and Westminster Hospital, London
    Postgrad Med J 79:691-4. 2003
    ..These findings have implications for the treatment of individuals presenting with serious infections in which antibiotic therapy needs to be instituted before identification and sensitivities are known...
  29. ncbi Outcome in AIDS-related systemic non-Hodgkin lymphoma and leptomeningeal disease is not predicted by a CT brain scan
    C L Davies
    Department of Oncology, Imperial College School of Science, Medicine and Technology, Chelsea and Westminster Hospital, London, United Kingdom
    AJNR Am J Neuroradiol 28:1988-90. 2007
    ..We investigated the utility of brain CT in determining the outcome of leptomeningeal disease, despite MR imaging being the gold standard...
  30. ncbi Does HIV adversely influence the outcome in advanced non-small-cell lung cancer in the era of HAART?
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Br J Cancer 89:457-9. 2003
    ..This suggests that the survival of patients with HIV-related NSCLC may have improved since the introduction of HAART, and this may be due to a decrease in HIV-related deaths...
  31. ncbi Anal intraepithelial neoplasia in HIV positive people
    F Martin
    Department of Oncology, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
    Sex Transm Infect 77:327-31. 2001
    ..However, routine anal cytological screening will surely have to await an effective proved intervention for AIN and this would seem to be a pressing clinical goal...
  32. ncbi CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
    Mark Bower
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Haematologica 94:875-80. 2009
    ..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma...
  33. ncbi Treatment outcome in presumed and confirmed AIDS-related primary cerebral lymphoma
    M Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, U K
    Eur J Cancer 35:601-4. 1999
    ..Recent improvements in outcome have been reported with systemic chemotherapy in HIV-PCNSL and may influence the need for earlier definitive diagnosis in the future...
  34. ncbi The significance of Epstein-Barr virus detected in the cerebrospinal fluid of people with HIV infection
    J Wang
    Department of Oncology and HIV Medicine, Chelsea and Westminster Hospital, London, UK
    HIV Med 8:306-11. 2007
    ..However, EBV may also be detected in the CSF of patients without PCL, and here the significance is uncertain...
  35. ncbi Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre
    K Fife
    Medical Oncology Unit, Charing Cross Hospital, London, UK
    Int J STD AIDS 9:751-5. 1998
    ..This preliminary study demonstrates that thalidomide has activity in the treatment of AIDS-KS and that clinical response is associated with a reduction of HHV8 DNA titre in peripheral blood...
  36. ncbi The common heat shock protein receptor CD91 is up-regulated on monocytes of advanced melanoma slow progressors
    J Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 138:312-6. 2004
    ....
  37. ncbi HIV-related lung cancer -- a growing concern?
    T Powles
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Int J STD AIDS 14:647-51. 2003
    ..Thus lung cancer and possibly other non-AIDS-defining malignancies may become an increasingly frequent problem whose prognosis has not improved in the era of HAART...
  38. ncbi The changing role of radiotherapy in AIDS-related malignancies
    J Lukawska
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Clin Oncol (R Coll Radiol) 15:2-6. 2003
    ..Chemoradiotherapy remains the mainstay of management for anal cancer, has a central role in cervical cancer and non-AIDS defining malignancies in this population...
  39. ncbi Altered phenotype of regulatory T cells associated with lack of human immunodeficiency virus (HIV)-1-specific suppressive function
    C T Burton
    Department of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK
    Clin Exp Immunol 166:191-200. 2011
    ..We propose that before immunotherapeutic manipulation of T(regs) is considered, the immunoregulatory profile and distribution kinetics of this population in chronic HIV-1 infection must be elucidated fully...
  40. ncbi The value of anal cytology and human papillomavirus typing in the detection of anal intraepithelial neoplasia: a review of cases from an anoscopy clinic
    P A Fox
    Department of HIV and Genitourinary Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Sex Transm Infect 81:142-6. 2005
    ..Previous studies have reached differing conclusions about the utility of anal cytology as a screening tool for anal intraepithelial neoplasia (AIN). There is a need also to establish whether HPV typing offers a useful adjunct to screening...
  41. ncbi Chemoradiotherapy for anal cancer in HIV patients causes prolonged CD4 cell count suppression
    M Alfa-Wali
    Department of Surgery and Cancer, Imperial College London, and Department of Clinical Oncology, Royal Marsden Hospital, London, UK
    Ann Oncol 23:141-7. 2012
    ..We present the clinical features and treatment outcomes of anal cancer in 60 HIV-positive patients over a 20-year period...
  42. ncbi Imaging features of multicentric Castleman's disease in HIV infection
    J C Hillier
    Clinical Radiology, Chelsea and Westminster Hospital, London, UK
    Clin Radiol 59:596-601. 2004
    ..To describe the computed tomography (CT) features of human immunodeficiency virus (HIV)-associated Castleman's disease...
  43. ncbi HIV-related testicular cancer
    T Powles
    Department of HIV, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Int J STD AIDS 14:24-7. 2003
  44. ncbi The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours
    T Powles
    Charing Cross Gestational Trophoblastic Centre, London, UK
    Br J Cancer 95:1145-7. 2006
    ..The interval between antecedent pregnancy and diagnosis in high-risk GTT is of prognostic significance. This gives some insight into the pathogenesis of the disease...
  45. ncbi A questionnaire survey of stress and bullying in doctors undertaking research
    J Stebbing
    Chelsea and Westminster Hospital, London, UK
    Postgrad Med J 80:93-6. 2004
    ..Research is an increasingly important aspect of higher medical training for many doctors. Studies investigating sources of stress, isolation, and workplace bullying have not previously sought information in this setting...
  46. ncbi Randomized trial to compare the efficacy and toxicity of cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with methotrexate mitoxantrone (MM) in advanced carcinoma of the breast
    C Harper Wynne
    Department of Medical Oncology, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    Br J Cancer 81:316-22. 1999
    ....
  47. ncbi Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer
    A M Waterston
    Department of Cancer Medicine, Faculty of Medicine, Imperial College School of Medicine, London, W12 0HS, UK
    Cancer Immunol Immunother 54:848-57. 2005
    ..However, since the antibodies were only able to cross-react with partly denatured TNFalpha, evaluation of safety and tumour responses to the TNFalpha vaccine was compromised...
  48. ncbi High-dose therapy including carboplatin adjusted for renal function in patients with relapsed or refractory germ cell tumour: outcome and prognostic factors
    M P Lyttelton
    Department of Haematology, Imperial College School of Medicine, Hammersmith Hospitals NHS Trust, London, UK
    Br J Cancer 77:1672-6. 1998
    ....
  49. ncbi An open-label study of tenofovir in HIV-1 and Hepatitis B virus co-infected individuals
    M Nelson
    Chelsea and Westminster Hospital, London, UK
    AIDS 17:F7-10. 2003
    ..INTERPRETATION: These results indicate that 52 weeks of tenofovir in addition to antiretroviral therapy is active against HBV, and it appears to overcome lamivudine resistance...
  50. ncbi Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir
    N Kumar
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK
    Int J STD AIDS 23:59-60. 2012
    ..This emphasizes that while monitoring for adverse effects is recommended, physicians must consider all alternative causes for biochemical abnormalities prior to discontinuing tenofovir and delaying appropriate management...
  51. ncbi Absence of cyclin-D2 and Bcl-2 expression within the germinal centre type of diffuse large B-cell lymphoma identifies a very good prognostic subgroup of patients
    F Amen
    Department of Histopathology, Hammersmith Hospital and Imperial College, London, UK
    Histopathology 51:70-9. 2007
    ..To validate and improve the existing algorithm (proposed by Hans et al.) to classify diffuse large B-cell lymphoma (DLBCL)...
  52. ncbi The current role of surgery in the management of residual disease
    T J Christmas
    Department of Urology, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    Curr Opin Urol 9:439-42. 1999
    ..Retroperitoneal lymph node dissection also appears to be worthwhile in chemotherapy-resistant disease ('desperation retroperitoneal lymph node dissection'), although the relapse rate is higher in this group...
  53. ncbi Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas
    S Balesaria
    Department of Cancer Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    Br J Cancer 81:1371-7. 1999
    ..We conclude that LOH for chromosome 10 is an independent, adverse prognostic variable in high-grade glioma...
  54. ncbi DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma
    S Lee
    Laboratory of Cancer Genetics and Epigenetics, Breakthrough Breast Cancer, Institute of Cancer Research, Fulham Road, London, UK
    Br J Cancer 103:265-74. 2010
    ..Little is known of the expression, regulation or function of the DUSPs in human neoplasia...
  55. ncbi Clostridium difficile infection, hospital geography and time-space clustering
    P B Kroker
    Department of Medicine, Day Unit, Chelsea and Westminster Hospital, Fulham Road, London SW10 9NH, UK
    QJM 94:223-5. 2001
    ..The results support the importance of infection control measures in the prevention of C. difficile-related disease...
  56. ncbi Prognostic significance of immune subset measurement in individuals with AIDS-associated Kaposi's sarcoma
    Justin Stebbing
    Imperial College of Science, Medicine, and Technology, Department of Oncology, The Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 25:2230-5. 2007
    ..Because immune subset measurement is often performed in HIV-positive individuals, we examined whether these were predictive of mortality independently of the prognostic index, or could predict time to progression of KS...
  57. ncbi The effects of HAART on AIDS-related Kaposi's sarcoma and non-Hodgkin's lymphoma
    Gail Clayton
    J HIV Ther 11:51-3. 2006
  58. ncbi Non-AIDS-defining cancers in people with HIV infection: a sleeping giant?
    Thomas Powles
    Department of Medical Oncology, St Bartholomew's Hospital, West Smithfield, London
    J HIV Ther 11:57-60. 2006
  59. ncbi Immunologic recovery in survivors following chemotherapy for AIDS-related non-Hodgkin lymphoma
    Mark Bower
    Department of Oncology, Imperial College School of Medicine, London, UK
    Blood 111:3986-90. 2008
    ..Chemotherapy and concomitant HAART for AIDS-related NHL does not cause prolonged suppression of lymphocyte subsets. These data should provide reassurance regarding the long-term consequences of chemotherapy in these individuals...
  60. ncbi The role of transbronchial fine needle aspiration in an integrated care pathway for the assessment of patients with suspected lung cancer
    Pallav L Shah
    Department of Respiratory Medicine, Royal Brompton Hospital, London, England, UK
    J Thorac Oncol 1:324-7. 2006
    ..TBNA improves the diagnostic yield and staging of patients with lung cancer. Moreover, it is a simple, low-cost, and safe test, which should be incorporated into the diagnostic pathway of patients with suspected lung cancer...
  61. ncbi Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor
    Justin Stebbing
    Department of Immunology, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 102:1806-14. 2003
    ..These results have important implications for the etiopathogenesis of KS and for the development and design of any compounds, including vaccines, derived from cellular lysates...
  62. ncbi A comparison of regimens based on non-nucleoside reverse transcriptase inhibitors or protease inhibitors in preventing Kaposi's sarcoma
    Simon Portsmouth
    Department of Immunology, Chelsea and Westminster Hospital, London, UK
    AIDS 17:F17-22. 2003
    ..CONCLUSION: PI- and NNRTI-based HAART regimens are equally effective as protection against KS. This is the first study to demonstrate a decreased incidence of an AIDS-defining disease with NNRTI-based therapy...
  63. ncbi Highly active antiretroviral therapy and human immunodeficiency virus-associated primary cerebral lymphoma
    Mark Bower
    Department of Oncology and HIV Medicine, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    J Natl Cancer Inst 98:1088-91. 2006
    ..013), and patients were more likely to have the diagnosis of PCL confirmed histologically or by polymerase chain reaction (77% versus 26%; P<.001). Exposure to specific antiretroviral agents was not associated with risk for PCL...
  64. ncbi Effects of combination chemotherapy and highly active antiretroviral therapy on immune parameters in HIV-1 associated lymphoma
    Tom Powles
    Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    AIDS 16:531-6. 2002
    ..The CD4 T-cell count falls by 50% during chemotherapy and this will help to identify patients who require opportunistic infection prophylaxis during chemotherapy...
  65. ncbi Should cervical cancer be an acquired immunodeficiency syndrome-defining cancer?
    Mark Bower
    Department of Oncology, Chelsea and Westminster Hospital, London, United Kingdom
    J Clin Oncol 24:2417-9. 2006
  66. ncbi Virological failure and subsequent resistance profiles in individuals exposed to atazanavir
    Justin Stebbing
    Department of HIV Medicine, The Chelsea and Westminster Hospital, Imperial College School of Science, Technology and Medicine, London, UK
    AIDS 21:1826-8. 2007
    ..This is particularly important because of the increasing use of atazanavir monotherapy, and implies that treatment failure is caused by lack of potency...
  67. ncbi Risk of cancers during interrupted antiretroviral therapy in the SMART study
    Michael J Silverberg
    Division of Research, Kaiser Permanente Northern California, Oakland, California 94110, USA
    AIDS 21:1957-63. 2007
    ..To compare rates of AIDS-defining and non-AIDS-defining malignancies between patients on a CD4 T-cell-guided antiretroviral therapy (ART) strategy and continuous ART...
  68. ncbi Lack of response of anal intra-epithelial neoplasia to highly active antiretroviral therapy
    Paul Fox
    AIDS 17:279-80. 2003
  69. ncbi Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: a cohort study
    Gail V Matthews
    Department of HIV Medicine, Chelsea Hospital, London, UK
    AIDS 16:53-61. 2002
    ..Clinical trial data is required to confirm these findings...
  70. ncbi The immunological effects of concomitant highly active antiretroviral therapy and liposomal anthracycline treatment of HIV-1-associated Kaposi's sarcoma
    Ben Esdaile
    Department of Oncology, Chelsea and Westminster Hospital, London, UK
    AIDS 16:2344-7. 2002
    ..We showed in 50 patients that liposomal anthracyclines used with HAART did not lead to a significant loss of CD4 or CD8 cells or an increase in HIV-1 viral load during or up to 12 months after chemotherapy...
  71. ncbi The heat-shock protein receptor CD91 is up-regulated in monocytes of HIV-1-infected "true" long-term nonprogressors
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Blood 101:4000-4. 2003
    ..The ability of CD91 to internalize alpha-defensins and to cross-present exogenous antigen to cytotoxic T lymphocytes through major histocompatibility complex (MHC) class 1 may maintain CD8(+) responses in these patients...
  72. ncbi Triple-class antiretroviral agent resistance in a large cohort: prevalence and clinical outcomes
    Rachael Jones
    Arch Intern Med 168:1926-7. 2008
  73. ncbi Lymph nodes involved by multicentric Castleman disease among HIV-positive individuals are often involved by Kaposi sarcoma
    Kikkeri N Naresh
    Department of Histopathology, Hammersmith Hospital and Imperial College, London, UK
    Am J Surg Pathol 32:1006-12. 2008
    ....
  74. ncbi Use of antidepressants and risk of cancer in individuals infected with HIV
    Justin Stebbing
    Imperial College, Imperial Healthcare NHS Trust, Charing Cross Hospital, Department of Medical Oncology, London, UK
    J Clin Oncol 26:2305-10. 2008
    ..We aimed to assess whether different classes of antidepressants were associated with changes in cancer incidence in a population of HIV-1 infected individuals, based on duration of exposure...
  75. ncbi Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era
    Douglas C Macdonald
    Chelsea and Westminster Hospital, London, United Kingdom
    World J Gastroenterol 14:1657-63. 2008
    ..Once HCC develops, there is growing evidence that HIV co-infection should not preclude conventional therapeutic strategies, including liver transplantation...
  76. ncbi AIDS-associated Kaposi's sarcoma associated with a low viral load and a high CD4 cell count
    Justin Stebbing
    AIDS 22:551-2. 2008
  77. ncbi Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin's lymphoma: a cohort study
    Laura Waters
    Department of HIV Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 116:161-3. 2005
    ..1 of 10(4) patient years during HIV alone (p = 0.9). In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma...
  78. ncbi The risks and incidence of K65R and L74V mutations and subsequent virologic responses
    Laura Waters
    Department of HIV Medicine, Chelsea and Westminster Hospital and Imperial College School of Medicine, London, United Kingdom
    Clin Infect Dis 46:96-100. 2008
    ..If suboptimal HAART was used, patients with K65R experienced significantly higher rates of virologic suppression than did those with L74V (P = .01)...
  79. ncbi Emtricitabine intolerance in treatment-experienced patients switched from lamivudine: a method of assessing toxicity
    Katrina Pollock
    J Antimicrob Chemother 58:227-8. 2006
  80. ncbi Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Chelsea and Westminster Hospital, London SW10 9NH, UK
    AIDS 17:1998-2000. 2003
    ..KS-associated herpesvirus replication was not demonstrated in vivo or in vitro within NK cells, suggesting that NK cells do not contribute to the resolution of KS. Their role appears limited to events occurring during early infection...
  81. ncbi A prognostic index for systemic AIDS-related non-Hodgkin lymphoma treated in the era of highly active antiretroviral therapy
    Mark Bower
    The Chelsea and Westminster Hospital, London, United Kingdom
    Ann Intern Med 143:265-73. 2005
    ..The established International Prognostic Index for lymphomas has not included patients with systemic AIDS-related non-Hodgkin lymphoma...
  82. ncbi A randomized trial to investigate the recycling of stavudine and didanosine with and without hydroxyurea in salvage therapy (RESTART)
    Justin Stebbing
    The St Stephen s Centre, The Chelsea and Westminster Hospital, London, UK
    J Antimicrob Chemother 53:501-5. 2004
    ....
  83. ncbi The effect of statins on HIV rebound and blips
    Laura Waters
    J Acquir Immune Defic Syndr 39:637-8. 2005
  84. ncbi Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and a decreased cholesterol
    Victoria Latham
    The St Stephen's Centre, The Chelsea and Westminster Hospital, London, UK
    J Antimicrob Chemother 56:186-9. 2005
    ..CONCLUSIONS: In compliant heavily pre-treated individuals with less than 2 TAMs, salvage therapy with trizivir and tenofovir is associated with suppression of viraemia and an improved lipid profile...
  85. ncbi HIV and the risk of lung cancer
    Thomas Powles
    J Clin Oncol 22:1348-9; author reply 1349-50. 2004
  86. ncbi Conservation of unique cell-surface CD antigen mosaics in HIV-1-infected individuals
    Adrian Woolfson
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Box 111, Cambridge CB2 2SP, United Kingdom
    Blood 106:1003-7. 2005
    ..Their invariant nature indicates an irreversible component to retroviral infection and suggests the utility of CD antigen expression patterns in other disease settings...
  87. ncbi Fifty years of multicentric Castleman's disease
    Ashita Waterston
    Department of Oncology The Chelsea and Westminster Hospital London UK
    Acta Oncol 43:698-704. 2004
    ..The introduction of HAART has altered the natural history of HIV infection; however, its impact on MCD is difficult to ascertain. Optimization and consensus in treatment of these patients remains a target for the future...
  88. ncbi The evidence-based treatment of AIDS-related non-Hodgkin's lymphoma
    Justin Stebbing
    Medical Day Unit, Department of Oncology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cancer Treat Rev 30:249-53. 2004
    ..In this review, we discuss the evidence for choosing particular therapies in patients with AIDS-related NHL...
  89. ncbi Antiretroviral treatment regimens and immune parameters in the prevention of systemic AIDS-related non-Hodgkin's lymphoma
    Justin Stebbing
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    J Clin Oncol 22:2177-83. 2004
    ..5; 95% CI, 0.4 to 0.7) or no antiretrovirals (P <.001). CONCLUSION: Effective HAART-induced maintenance of CD4 and CD8 counts protects from systemic AIDS-related NHL...
  90. ncbi A randomized study comparing a three- and four-drug HAART regimen in first-line therapy (QUAD study)
    Chloe Orkin
    The St Stephen's Centre, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH
    J Antimicrob Chemother 55:246-51. 2005
    ..CONCLUSIONS: No differences in any analyses were observed between a standard of care regimen (zidovudine/lamivudine and efavirenz) and the quad regimen (zidovudine/lamivudine/abacavir and efavirenz)...
  91. ncbi Renal dysfunction with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy regimens is not observed more frequently: a cohort and case-control study
    Rachael Jones
    Department of HIV and Genitourinary Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1489-95. 2004
    ..We investigated the overall incidence and risk of renal dysfunction in individuals receiving tenofovir DF and compared this with other antiretrovirals...
  92. ncbi Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients
    Justin Stebbing
    The Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Cell Res 14:251-6. 2004
    ..These findings are compatible with results of prior clinical studies that found no evidence that HCV co-infection altered HIV disease progression and has implications for immunotherapeutic approaches in co-infected individuals...
  93. ncbi Hepatitis C virus infection in HIV type 1-infected individuals does not accelerate a decrease in the CD4+ cell count but does increase the likelihood of AIDS-defining events
    Justin Stebbing
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, United Kingdom
    Clin Infect Dis 41:906-11. 2005
    ..In conclusion, there was an increased number of adverse events in coinfected individuals, compared with individuals infected with HIV-1 alone...
  94. ncbi The efficacy of ritonavir in the prevention of AIDS-related Kaposi's sarcoma
    Justin Stebbing
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom
    Int J Cancer 108:631-3. 2004
    ..This is consistent with data suggesting that regression of KS is mediated by an overall improvement in immune function and not by the effects of specific antiretrovirals...
  95. ncbi Transmission of hepatitis C virus among HIV-positive homosexual men and response to a 24-week course of pegylated interferon and ribavirin
    Yvonne C Gilleece
    St. Stephen's Centre, Chelsea and Westminster Hospital, London, UK
    J Acquir Immune Defic Syndr 40:41-6. 2005
    ..Because a high percentage of individuals seroconvert spontaneously, treatment should be delayed until after 12 weeks...
  96. ncbi A prognostic index for AIDS-associated Kaposi's sarcoma in the era of highly active antiretroviral therapy
    Justin Stebbing
    Department of Oncology, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Lancet 367:1495-502. 2006
    ..We developed a simple model for predicting mortality on the basis of clinical characteristics present at the time of diagnosis of Kaposi's sarcoma...
  97. ncbi The management of meningeal lymphoma in patients with HIV in the era of HAART: intrathecal depot cytarabine is effective and safe
    Danish Mazhar
    Blood 107:3412-4. 2006
  98. ncbi A tale of three Hs: HPV, HIV & HAART
    Justin Stebbing
    Future Oncol 2:1-9. 2006
  99. ncbi The host control of lytic and latent infection with human herpesvirus-8
    Justin Stebbing
    J Infect Dis 193:1051-3. 2006
  100. ncbi Protease inhibitors potentiate chemotherapy-induced neutropenia
    Mark Bower
    Department of Oncology, The Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, United Kingdom
    Blood 104:2943-6. 2004
    ..PI-based HAART appears to significantly potentiate the myelotoxicity of CDE chemotherapy. This potentiation may be a consequence of microsomal enzyme inhibition reducing the metabolism of cytotoxics in this regimen...
  101. ncbi Multiple human papillomavirus types appear to be a feature of anal not cervical intra-epithelial neoplasia
    Justin Stebbing
    AIDS 17:2401. 2003