Oliver Billker

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite
    Oliver Billker
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Cell 117:503-14. 2004
  2. ncbi Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion
    Inga Siden-Kiamos
    Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 60:1355-63. 2006
  3. ncbi An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite
    Rita Tewari
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 58:1253-63. 2005
  4. ncbi Generation of gene targeting constructs for Plasmodium berghei by a PCR-based method amenable to high throughput applications
    Andrea Ecker
    Division of Cell and Molecular Biology, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Mol Biochem Parasitol 145:265-8. 2006
  5. ncbi Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut
    Meiji Arai
    Department of Biological Sciences, Imperial College of Science, Technology, and Medicine, London SW7 2AZ, UK
    Exp Parasitol 106:30-6. 2004
  6. ncbi Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase
    Louisa McRobert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Biol 6:e139. 2008
  7. ncbi Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes
    Christian Doerig
    INSERM U609, Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 Glasgow University Place, Glasgow G12 8TA, Scotland, UK
    Biochim Biophys Acta 1754:132-50. 2005
  8. ncbi A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites
    Luc Reininger
    INSERM U609, Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow G11 6NU, Scotland, United Kingdom
    J Biol Chem 280:31957-64. 2005
  9. ncbi Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells
    Alida Coppi
    Department of Medical Parasitology, 341 East 25th Street, New York University School of Medicine, New York, NY 10010, USA
    Cell Host Microbe 2:316-27. 2007
  10. ncbi The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes
    Yanjie Liu
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 22:1051-68. 2008

Collaborators

  • Rita Tewari
  • Christian Doerig
  • Andrea Ecker
  • Inga Siden-Kiamos
  • Meiji Arai
  • R E Sinden
  • William Snell
  • Yanjie Liu
  • Louisa McRobert
  • Alida Coppi
  • Luc Reininger
  • Ross M Cummings
  • Andrew M Blagborough
  • David A Baker
  • Robert E Steele
  • Sara Garbom
  • Nick V Grishin
  • Quinton L Fivelman
  • Cathy J Taylor
  • Jue Ning
  • Spencer D Polley
  • Wensheng Deng
  • Jimin Pei
  • Jeffrey D Esko
  • Roger Lawrence
  • Photini Sinnis
  • Brandy L Bennett
  • Joseph R Bishop
  • Lisa Ranford-Cartwright
  • Leonie Harmse
  • Clare Fennell
  • Jeremy Packer
  • Dominique Dorin-Semblat
  • Dean Goldring
  • Arunima Mukhopadhyay

Detail Information

Publications11

  1. ncbi Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite
    Oliver Billker
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Cell 117:503-14. 2004
    ..berghei. This study reveals an unexpected function for a plant-like signaling pathway in cell cycle regulation and life cycle progression of a malaria parasite...
  2. ncbi Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion
    Inga Siden-Kiamos
    Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 60:1355-63. 2006
    ....
  3. ncbi An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite
    Rita Tewari
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Mol Microbiol 58:1253-63. 2005
    ....
  4. ncbi Generation of gene targeting constructs for Plasmodium berghei by a PCR-based method amenable to high throughput applications
    Andrea Ecker
    Division of Cell and Molecular Biology, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Mol Biochem Parasitol 145:265-8. 2006
  5. ncbi Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut
    Meiji Arai
    Department of Biological Sciences, Imperial College of Science, Technology, and Medicine, London SW7 2AZ, UK
    Exp Parasitol 106:30-6. 2004
    ..Further elucidation of the mechanism how INH inhibits parasite development specifically on mosquito stages may allow us to identify new targets for malaria control strategy...
  6. ncbi Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase
    Louisa McRobert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Biol 6:e139. 2008
    ..falciparum, and demonstrates the feasibility of selective inhibition of a crucial regulator of the malaria parasite life cycle...
  7. ncbi Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes
    Christian Doerig
    INSERM U609, Wellcome Centre for Molecular Parasitology, University of Glasgow, 120 Glasgow University Place, Glasgow G12 8TA, Scotland, UK
    Biochim Biophys Acta 1754:132-50. 2005
    ....
  8. ncbi A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites
    Luc Reininger
    INSERM U609, Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow G11 6NU, Scotland, United Kingdom
    J Biol Chem 280:31957-64. 2005
    ..Cell cycle progression in the zygote is identified as a likely precondition for its morphological transition to the ookinete and for the successful establishment of a malaria infection in the mosquito...
  9. ncbi Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells
    Alida Coppi
    Department of Medical Parasitology, 341 East 25th Street, New York University School of Medicine, New York, NY 10010, USA
    Cell Host Microbe 2:316-27. 2007
    ..These findings explain how sporozoites retain their infectivity for an organ that is far from their site of entry...
  10. ncbi The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes
    Yanjie Liu
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 22:1051-68. 2008
    ..Membrane dye experiments show that HAP2 is essential for membrane merger. Thus, in two distantly related eukaryotes, species-limited proteins govern access to a conserved protein essential for membrane fusion...
  11. ncbi Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei
    Oliver Billker
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AZ UK
    J Eukaryot Microbiol 49:489-97. 2002
    ..Our observations suggest that azadarachtin specifically disrupts the patterning of microtubules into more complex structures, such as mitotic spindles and axonemes...