R A C Hughes

Summary

Country: UK

Publications

  1. ncbi Give or take? Intravenous immunoglobulin or plasma exchange for Guillain-Barré syndrome
    Richard Ac Hughes
    Cochrane Neuromuscular Disease Group, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Crit Care 15:174. 2011
  2. ncbi Clinical applications of intravenous immunoglobulins in neurology
    R A C Hughes
    National Hospital for Neurology and Neurosurgery, Queens Square, London, UK
    Clin Exp Immunol 158:34-42. 2009
  3. ncbi European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Socie
    R D M Hadden
    Department of Neurology, King s College Hospital, London, UK
    Eur J Neurol 13:809-18. 2006
  4. ncbi Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy
    L Sanvito
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 80:333-8. 2009
  5. ncbi Practice parameter: immunotherapy for Guillain-Barré syndrome: report of the Quality Standards Subcommittee of the American Academy of Neurology
    R A C Hughes
    Department of Neuroimmunology, Guy's, King's and St. Thomas' School of Medicine, London, UK
    Neurology 61:736-40. 2003
  6. ncbi A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barré syndrome
    J Pritchard
    Department of Clinical Neurosciences, Guy's, King's and St. Thomas' School of Medicine, London, UK
    Neurology 61:1282-4. 2003
  7. ncbi Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    Lancet Neurol 7:136-44. 2008
  8. ncbi European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripher
    R A C Hughes
    King s College London School of Medicine, London, UK
    Eur J Neurol 13:326-32. 2006
  9. ncbi A prospective study of physiotherapist prescribed community based exercise in inflammatory peripheral neuropathy
    R C Graham
    Applied Biomedical Research Division, Shepherd s House, Guy s Campus, King s College London, London, UK
    J Neurol 254:228-35. 2007
  10. ncbi Characterization of matrix metalloproteinases in denervated muscle
    M Demestre
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, London, SEI 1UL, UK
    Neuropathol Appl Neurobiol 31:545-55. 2005

Detail Information

Publications13

  1. ncbi Give or take? Intravenous immunoglobulin or plasma exchange for Guillain-Barré syndrome
    Richard Ac Hughes
    Cochrane Neuromuscular Disease Group, MRC Centre for Neuromuscular Disease, PO Box 114, National Hospital for Neurology and Neurosurgery, 8 11 Queen Square, London WC1N 3BG, UK
    Crit Care 15:174. 2011
    ..Two larger trials in adults showed the opposite result...
  2. ncbi Clinical applications of intravenous immunoglobulins in neurology
    R A C Hughes
    National Hospital for Neurology and Neurosurgery, Queens Square, London, UK
    Clin Exp Immunol 158:34-42. 2009
    ..These changes at the molecular level were accompanied by improved cognitive function, and large-scale randomized trials are under way...
  3. ncbi European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Socie
    R D M Hadden
    Department of Neurology, King s College Hospital, London, UK
    Eur J Neurol 13:809-18. 2006
    ..Objectives. To prepare evidence-based and consensus guidelines on the clinical management of patients with both a demyelinating neuropathy and a paraprotein (paraproteinaemic demyelinating neuropathy, PDN)...
  4. ncbi Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy
    L Sanvito
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 80:333-8. 2009
    ..Evidence that chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease was sought, by studying cellular and humoral immune responses to peripheral nerve myelin proteins...
  5. ncbi Practice parameter: immunotherapy for Guillain-Barré syndrome: report of the Quality Standards Subcommittee of the American Academy of Neurology
    R A C Hughes
    Department of Neuroimmunology, Guy's, King's and St. Thomas' School of Medicine, London, UK
    Neurology 61:736-40. 2003
    ....
  6. ncbi A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barré syndrome
    J Pritchard
    Department of Clinical Neurosciences, Guy's, King's and St. Thomas' School of Medicine, London, UK
    Neurology 61:1282-4. 2003
    ..IFN[beta] did not have any unexpected interaction with IVIg and there was no significant difference in rate of improvement...
  7. ncbi Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London, Guy s Hospital, London, UK
    Lancet Neurol 7:136-44. 2008
    ..We aimed to establish whether 10% caprylate-chromatography purified immune globulin intravenous (IGIV-C) has short-term and long-term benefit in patients with CIDP...
  8. ncbi European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripher
    R A C Hughes
    King s College London School of Medicine, London, UK
    Eur J Neurol 13:326-32. 2006
    ....
  9. ncbi A prospective study of physiotherapist prescribed community based exercise in inflammatory peripheral neuropathy
    R C Graham
    Applied Biomedical Research Division, Shepherd s House, Guy s Campus, King s College London, London, UK
    J Neurol 254:228-35. 2007
    ..Future randomised controlled trials are needed to examine the efficacy of this complex community based intervention...
  10. ncbi Characterization of matrix metalloproteinases in denervated muscle
    M Demestre
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, London, SEI 1UL, UK
    Neuropathol Appl Neurobiol 31:545-55. 2005
    ..Further experiments are required to test the hypothesis that MMP inhibition may be beneficial in protecting muscle from excessive remodelling following denervation and therefore improve reinnervation...
  11. ncbi Intravenous immunoglobulin modulates lymphocyte CD54 and monocyte FcgammaRII expression in patients with chronic inflammatory neuropathies
    A Creange
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, SE1 1UL, London, UK
    J Neuroimmunol 135:91-5. 2003
    ..Thus, the mechanism of action of IVIg in both CIDP and MMN may involve inhibition of T cell transmigration and modulation of antigen presentation capacities through FcgammaR expression...
  12. ncbi Variable phenotypes are associated with PMP22 missense mutations
    M Russo
    MRC Centre for Neuromuscular Diseases, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
    Neuromuscul Disord 21:106-14. 2011
    ....
  13. ncbi Systematic reviews of treatment for inflammatory demyelinating neuropathy
    R A C Hughes
    Cochrane Neuromuscular Disease Review Group, Guy's, King's and St Thomas' School of Medicine, Guy's Hospital, London, UK
    J Anat 200:331-9. 2002
    ..They already demonstrate major deficiencies in the existing evidence base...