Tarek El-Toukhy

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..A favourable ethical opinion has been obtained (REC reference: 09/H0804/32). TRAIL REGISTRATION: The trial has been assigned the following ISRCTN number: ISRCTN35859078...

..The history and ethics involved in performing PGD together with human leukocyte antigen (HLA) testing (PGD-H) to create matched siblings suitable for haematopoietic stem cell transplant (HSCT) are discussed...

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..To examine the relationship between endometrial thickness and outcome of medicated frozen-thawed embryo replacement (FER) cycles...

..We assessed the effect of BMI on the risk of miscarriage in women conceiving following single blastocyst transfer (SBT) after controlling for confounding factors...

..Currently available evidence does not favour any one pituitary suppression regimen for women with poor ovarian response undergoing IVF/ICSI treatment...

..82) showing only marginal improvement over dAFC alone. In conclusion, the performance of dAFC is the same regardless of the definition used for the size of antral follicles...

..In conclusion, raised BMI is associated with adverse pregnancy outcome in women undergoing IVF/ICSI treatment, including lower live birth rates. This effect is present in overweight as well as obese women...

..However, there is uncertainty about the effect of intramural fibroids that do not distort the endometrial cavity on IVF outcomes...

..A brief overview of the respective UK legislative system is also presented...

..There are conflicting results on whether the rate of blastocyst development before freezing influences the outcome of frozen-thawed blastocyst transfers...

..We describe our experience of using pre-implantation genetic diagnosis (PGD) for the prevention of SCD at a tertiary referral centre in London...

..Future robust randomized trials comparing outpatient hysteroscopy or mini-hysteroscopy with no intervention before IVF treatment would be a useful addition to further guide clinical practice...

..To assess the impact of survival of cryopreservation and thawing with all blastomeres intact on the outcome of frozen embryo replacement (FER) cycles...

..We conducted a systematic review of trials of aspirin during IVF or ICSI treatment to generate more precise estimates of effects and attempt to explore the reasons for the inconsistencies...

..The aim of this study was to assess the quality of websites providing information on infertility and its management in the UK. Differences between website types and affiliations were assessed...

..To evaluate the impact of acupuncture on the outcome of in-vitro fertilization treatment using data from published randomized studies. The main outcome measure of interest is the clinical pregnancy rate...

..The literature on such rare presentation is also reviewed to highlight its diagnostic features and prognosis...

..4%) compared to group B. All differences were statistically significant. CONCLUSION: The poor outcome of cycles with initial low response to COH appears not to be averted by doubling or increasing the hMG dose after 5 days of stimulation...

..Larger randomized trials with adequate sample size and standardized definition, classification and diagnosis of OHSS remain necessary...

..Such information may be helpful in counselling these patients who otherwise might anticipate an outcome related to their chronological age...

..This study compares the birth defect rate in women using preconception TNF-? inhibitor (Adalimumab) during an in vitro fertilization (IVF) cycle to a similar population of women not using these immunologic therapies...

..Retrospective analysis of large national databases is useful in identifying trends and generating hypothesis, but evaluation of these hypotheses in randomized trials remains necessary for objective validation...