Aaron N Cranston

Summary

Country: UK

Publications

  1. ncbi Modulation of medullary thyroid carcinoma penetrance suggests the presence of modifier genes in a RET transgenic mouse model
    Aaron N Cranston
    University of Cambridge and Cancer Research UK Department of Oncology, CIMR, Hills Road, Cambridge, CB2 2XY, United Kingdom
    Cancer Res 63:4777-80. 2003
  2. ncbi RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B
    Aaron N Cranston
    Cancer Research UK Department of Oncology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Cancer Res 66:10179-87. 2006
  3. ncbi Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma
    Matthias Drosten
    Department of Vectorology and Experimental Gene Therapy, University of Rostock, Schillingalle 70, D 18055 Rostock, Germany
    J Natl Cancer Inst 96:1231-9. 2004

Collaborators

Detail Information

Publications4

  1. ncbi Modulation of medullary thyroid carcinoma penetrance suggests the presence of modifier genes in a RET transgenic mouse model
    Aaron N Cranston
    University of Cambridge and Cancer Research UK Department of Oncology, CIMR, Hills Road, Cambridge, CB2 2XY, United Kingdom
    Cancer Res 63:4777-80. 2003
    ..These results are relevant to human MEN2 disease, because this model system may be used to study genes modifying thyroid tumor penetrance in the dominantly inherited human cancer syndrome...
  2. ncbi RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B
    Aaron N Cranston
    Cancer Research UK Department of Oncology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Cancer Res 66:10179-87. 2006
    ..Our findings have implications both in the clinic and in the successful development of novel kinase-targeted anticancer drugs...
  3. ncbi Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma
    Matthias Drosten
    Department of Vectorology and Experimental Gene Therapy, University of Rostock, Schillingalle 70, D 18055 Rostock, Germany
    J Natl Cancer Inst 96:1231-9. 2004
    ..We investigated the role of endogenous oncogenic RET autophosphorylation in maintaining the neoplastic phenotype in medullary thyroid carcinoma cells and orthotopic medullary thyroid carcinomas in RET transgenic mice...