Research Topics
| E A GouldSummaryAffiliation: Centre for Ecology and Hydrology Country: UK Publications
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Detail Information
Publications
Complete sequence of two tick-borne flaviviruses isolated from Siberia and the UK: analysis and significance of the 5' and 3'-UTRsT S Gritsun
Institute of Virology and Environmental Microbiology, Oxford, UK
Virus Res 49:27-39. 1997..The possible implications of these findings are discussed...- The 3' untranslated region of tick-borne flaviviruses originated by the duplication of long repeat sequences within the open reading frameT S Gritsun
Centre for Ecology and Hydrology, Mansfield Rd, Oxford 0X1 3SR, UK
Virology 350:269-75. 2006..We propose that the 3'UTR, and possibly the open reading frame, evolved through multiple duplications, deletions and mutations of a primordial sequence element... - First case of rabbit haemorrhagic disease in Canada: contaminated flying insect, vs. long-term infection hypothesisE A Gould
Unite des Virus Emergents, Faculte de Medecine Timone, 27 Bd Jean Moulin, Marseille Cedex 05, France
Mol Ecol 21:1042-7. 2012..The flying insect hypothesis of Peacock et al. is based on circumstantial evidence and, I believe, has a lower probability of being correct than my evidence-based long-term infection proposal... - Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?Xavier de Lamballerie
Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
Virol J 5:33. 2008..This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities... - Detection of seroconversion to West Nile virus, Usutu virus and Sindbis virus in UK sentinel chickensAlan Buckley
CEH Oxford, Mansfield Road, Oxford OX1 3SR, UK
Virol J 3:71. 2006..The proportion of seropositive chickens was higher for WNV than for Usutu virus or Sindbis virus. Attempts to isolate infectious virus or to detect viral RNA in the sera, failed... - Universal primers that amplify RNA from all three flavivirus subgroupsSheryl L Maher-Sturgess
Australian Biosecurity CRC, University of Queensland, St Lucia, QLD 4067, Australia
Virol J 5:16. 2008..Here we review the specificity of published primers, and describe a new universal primer pair that can detect a wide range of flaviviruses, including viruses from each of the recognised subgroups... - Pathogenic flavivirusesE A Gould
CEH Oxford, Mansfield Road, Oxford, UK
Lancet 371:500-9. 2008.... - Does antiviral therapy have a role in the control of Japanese encephalitis?E A Gould
Unite des Virus Emergents, Faculte de Medecine, 27 Boulevard Jean Moulin, 13005 Marseille, France
Antiviral Res 78:140-9. 2008..Here we briefly review the epidemiological problems presented by this virus, the present state of drug development and the contributory role that antiviral therapy might play in developing future control strategies for JE... - Impact of climate change and other factors on emerging arbovirus diseasesE A Gould
Unite des Virus Emergents, Faculte de Medecine Timone, 13385 Marseille, Cedex 05, France
Trans R Soc Trop Med Hyg 103:109-21. 2009..In this brief review we ask the question, are these diseases emerging because of climate change or do other factors play an equal or even more important role in their emergence?.. - Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their controlE A Gould
Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
Antiviral Res 87:111-24. 2010.... - Long-term survival of New Zealand rabbit haemorrhagic disease virus RNA in wild rabbits, revealed by RT-PCR and phylogenetic analysisN L Forrester
Centre for Ecology and Hydrology formerly Institute of Virology, Mansfield Road, Oxford OX1 3SR, UK
J Gen Virol 84:3079-86. 2003..Moreover, the co-circulation of other strains of RHDV in the same rabbit population, such as the Spanish strain, might also impact on their susceptibility to the bio-control agent... - Co-circulation of widely disparate strains of rabbit haemorrhagic disease virus could explain localised epidemicity in the United KingdomN L Forrester
Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
Virology 393:42-8. 2009.... - Phylogenetic analysis of rabbit haemorrhagic disease virus strains from the Arabian Peninsula: did RHDV emerge simultaneously in Europe and Asia?N L Forrester
Centre for Ecology and Hydrology formerly Institute of Virology, Mansfield Road, Oxford OX1 3SR, UK
Virology 344:277-82. 2006.... - Benign circulation of rabbit haemorrhagic disease virus on Lambay Island, EireN L Forrester
Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
Virology 358:18-22. 2007.... - Direct repeats in the 3' untranslated regions of mosquito-borne flaviviruses: possible implications for virus transmissionT S Gritsun
Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
J Gen Virol 87:3297-305. 2006.... - The degree of attenuation of tick-borne encephalitis virus depends on the cumulative effects of point mutationsT S Gritsun
Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford OX1 3SR, UK
J Gen Virol 82:1667-75. 2001..In terms of developing flavivirus vaccines, the impact of accumulating apparently minor mutations should be assessed in detail... - Genome sequence analysis of Tamana bat virus and its relationship with the genus FlavivirusX De Lamballerie
Unite des Virus Emergents, EA3292 IFR48, Universite de la Mediterranee, Faculte de Medecine, 27 Bd J Moulin, F13005 Marseille, France
J Gen Virol 83:2443-54. 2002.... - Biological consequences of deletions within the 3'-untranslated region of flaviviruses may be due to rearrangements of RNA secondary structureV Proutski
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
Virus Res 64:107-23. 1999..The functional significance of certain structural elements and their possible effect on the efficiency of viral replication in different cells are also discussed... - Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi ArabiaR N Charrel
Unité des Virus Emergents EA 3292, Universite de la Mediterranee, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille 13005, France
Biochem Biophys Res Commun 287:455-61. 2001.... - Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications?T S Gritsun
Centre for Ecology and Hydrology, Mansfield Rd, Oxford, 0X1 3SR, UK
Virology 366:8-15. 2007..Analysis of the alignments revealed that the panhandles represent evolutionary remnants of a long cyclisation domain that probably emerged through duplication of one of the UTR termini... - Louping ill virus envelope protein expressed by recombinant baculovirus and vaccinia virus fails to stimulate protective immunityS Y Shiu
NERC Institute of Virology and Environmental Microbiology, Oxford, UK
Virus Res 26:213-29. 1992.... - Tick-borne virus diseases of human interest in EuropeR N Charrel
Unite des Virus Emergents, Faculte de Medecine, Marseille, France
Clin Microbiol Infect 10:1040-55. 2004..Their ability to cause severe disease in man means that these viruses, as well as any clinical samples suspected of containing them, must be handled with specific and stringent precautions... - Molecular epidemiology of dengue virus type 3 in VenezuelaN Y Uzcategui
Centre for Ecology and Hydrology (CEH) Oxford, Formerly the Institute of Virology and Environmental Microbiology, Mansfield Road, UK
J Gen Virol 84:1569-75. 2003..Finally, no evidence of the re-emergence of the strain that circulated in Venezuela in the late 1960s and 1970s (genotype V) was found... - Evolution of the Japanese encephalitis serocomplex virusesE A Gould
Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford, OX1 3SR, UK
Curr Top Microbiol Immunol 267:391-404. 2002 - The 3' untranslated regions of Kamiti River virus and Cell fusing agent virus originated by self-duplicationT S Gritsun
Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
J Gen Virol 87:2615-9. 2006..These data provide new insights into the evolution of the flavivirus 3'UTR... - The 3' untranslated region of tick-borne flaviviruses originated by the duplication of long repeat sequences within the open reading frameT S Gritsun
Centre for Ecology and Hydrology, Mansfield Rd, Oxford 0X1 3SR, UK
Virology 354:217-23. 2006..We propose that the 3'UTR, and possibly the open reading frame, evolved through multiple duplications, deletions and mutations of a primordial sequence element... - Direct repeats in the flavivirus 3' untranslated region; a strategy for survival in the environment?T S Gritsun
Centre for Ecology and Hydrology, Mansfield Rd, Oxford 0X1 3SR, UK
Virology 358:258-65. 2007..We propose that short DRs represent the evolutionary remnants of LRSs rather than distinct molecular duplications. The relevance of DRs to virus replication enhancer function, and thus survival, is discussed... - Molecular epidemiology of Rabbit haemorrhagic disease virusS R Moss
Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK
J Gen Virol 83:2461-7. 2002..The high stability of RHDV RNA is also demonstrated by showing that it can be amplified and sequenced from rabbit bone marrow samples collected at least 7 weeks after the animal has died... - Cytotoxic T-cell activity is not detectable in Venezuelan equine encephalitis virus-infected miceL D Jones
CEH Institute of Virology, Mansfield Road, OX1 3SR, Oxford, UK
Virus Res 91:255-9. 2003..These data suggest that VEEV infection of mice does not elicit detectable CTL activity, and that CTL are unlikely to play a role in protection against virulent VEEV... - Tick-borne encephalitisT S Gritsun
CEH Institute of Virology and Environmental Microbiology, Mansfield Road, Oxford OX1 3SR, UK
Antiviral Res 57:129-46. 2003..This review also contains a brief history of vaccination against TBE including trials with live attenuated vaccine and modern tendencies in developing of vaccine virus strains... - Phylogeny of the genus flavivirus using complete coding sequences of arthropod-borne viruses and viruses with no known vectorF Billoir
Laboratoire de Virologie Moleculaire, Tropicale et Transfusionnelle, Unite des Virus Emergents, Faculte de Medecine de Marseille, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
J Gen Virol 81:781-90. 2000..In contrast, branching patterns at the deeper nodes of the tree were different from those reported in the previous study of NS5 sequences. The significance of these observations is discussed... - Evolution of base composition and codon usage bias in the genus FlavivirusG M Jenkins
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
J Mol Evol 52:383-90. 2001.... - The VIZIER project: preparedness against pathogenic RNA virusesB Coutard
Architecture et Fonction des Macromolecules Biologiques, CNRS, and Universités d Aix Marseille I et II, UMR 6098, ESIL case 925, 13288 Marseille Cedex 09, France
Antiviral Res 78:37-46. 2008.... - Pseudocowpox virus: the etiological agent of contagious ecthyma (Auzdyk) in camels (Camelus dromedarius) in the Arabian peninsulaM I Abubakr
West Riffa, Kingdom of Bahrain
Vector Borne Zoonotic Dis 7:257-60. 2007..The phylogeny also demonstrated that PCPV in Arabian camels was phylogenetically distinct from, and circulates independently of, ruminant-associated PCPV from Europe... - Recombination in rabbit haemorrhagic disease virus: possible impact on evolution and epidemiologyN L Forrester
Centre for Ecology and Hydrology, formerly Institute of Virology Mansfield Road Oxford OX1 3SR, United Kingdom
Virology 376:390-6. 2008..These observations imply that recombination may play a significant role in the evolution, epidemiology and diversity of RHDV... - Origin and evolution of 3'UTR of flaviviruses: long direct repeats as a basis for the formation of secondary structures and their significance for virus transmissionT S Gritsun
Centre for Ecology and Hydrology, Oxford, 0X1 3SR, United Kingdom
Adv Virus Res 69:203-48. 2007..The relevance of these flavivirus DRs to evolution, diversity, 3'UTR enhancer function, and virus transmission is reviewed... - Detection of Louping ill virus in clinical specimens from mammals and birds using TaqMan RT-PCRL Marriott
Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK
J Virol Methods 137:21-8. 2006.... - Rapid subgroup identification of the flaviviruses using degenerate primer E-gene RT-PCR and site specific restriction enzyme analysisM W Gaunt
Pathogen Molecular Biology and Biochemistry Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
J Virol Methods 128:113-27. 2005..Ninety percent of the known vector-borne flaviviruses with published full length E-gene sequences could be identified within 10 h... - The relationships between West Nile and Kunjin virusesJ H Scherret
Department of Microbiology and Parasitology, University of Queensland, Brisbane, Queensland 4072, Australia
Emerg Infect Dis 7:697-705. 2001..Our results suggest that KUN and WN viruses comprise a group of closely related viruses that can be differentiated into subgroups on the basis of genetic and antigenic analyses... - Dengue virus type 2 in Cuba, 1997: conservation of E gene sequence in isolates obtained at different times during the epidemicR Rodriguez-Roche
Department of Virology, PAHO/WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Havana, Cuba
Arch Virol 150:415-25. 2005..This "American/Asian" genotype has therefore gradually dispersed across the Caribbean region during the past 5 years... - Characterization of a siberian virus isolated from a patient with progressive chronic tick-borne encephalitisT S Gritsun
CEH Institute of Virology and Environmental Microbiology, Oxford OX1 3SR, United Kingdom
J Virol 77:25-36. 2003..These studies suggest that the patient from whom Za virus was isolated died due to increased pathogenicity of the latent virus following spontaneous mutagenesis... - Molecular epidemiology of dengue type 2 virus in Venezuela: evidence for in situ virus evolution and recombinationN Y Uzcategui
Centre for Ecology and Hydrology (CEH) Oxford, Oxford OX1 3SR, UK
J Gen Virol 82:2945-53. 2001.... - Characterization of tick-borne encephalitis virus-specific human T lymphocyte responses by stimulation with structural TBEV proteins expressed in a recombinant baculovirusI Gomez
Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Innsbruck, Austria
Viral Immunol 16:407-14. 2003..These lines were CD4+ and had a TH0 cytokine production pattern. Our results demonstrate the utility of recombinant viral proteins to study the generation and characterization of TBEV specific T cell responses... - Comparative analysis of the NS 1 gene sequences of dengue-1 viruses prototype Hawaii strain and Thai isolate TH-Sman, and determination of the intratypic variation of NS 1 protein among dengue-1 virusesS Y Shiu
Department of Microbiology, University of Hong Kong
Arch Virol 131:447-54. 1993..1% to 3.1% difference in the NS 1 protein among dengue-1 strains, which is comparable to that reported for dengue-1 envelope protein (0.2% to 3.6% difference) but less than that of dengue-2 NS 1 protein (0.6% to 7.4% difference)... - T cells from elderly persons respond to neoantigenic stimulation with an unimpaired IL-2 production and an enhanced differentiation into effector cellsI Gomez
Institute for Biomedical Ageing Research, Austrian Academy of Sciences, Rennweg 10, A-6020 Innsbruck, Austria
Exp Gerontol 39:597-605. 2004..Rapid generation of effector cells from naïve cells may at least partly counterbalance the decreasing size of the naïve T cell pool in elderly persons... - Epidemiology of rabbit haemorrhagic disease virus in the United Kingdom: evidence for seasonal transmission by both virulent and avirulent modes of infectionP J White
Institute of Biological Science, University of Stirling, Stirling FK9 4LA, UK
Epidemiol Infect 132:555-67. 2004..These findings suggest that many--perhaps most--strains of RHDV may be propagated through both 'pathogenic' and 'non-pathogenic' modes of behaviour. Transmission occurred predominantly during and just after the breeding season... - Susceptibility of mosquito and tick cell lines to infection with various flavivirusesC H Lawrie
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK
Med Vet Entomol 18:268-74. 2004.... - Phylogeny and molecular epidemiology of West Nile and Kunjin virusesJ H Scherret
Center for Tropical Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA
Curr Top Microbiol Immunol 267:373-90. 2002