Research Topics
| Timothy R WalshSummaryAffiliation: Cardiff University Country: UK Publications
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Publications
Emerging carbapenemases: a global perspectiveTimothy R Walsh
Cardiff University, Heath Park Hospital, UK
Int J Antimicrob Agents 36:S8-14. 2010..In particular, the media attention given to the NDM-1 metallo-?-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance...- Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological studyKarthikeyan K Kumarasamy
Department of Microbiology, Dr ALM PG IBMS, University of Madras, Chennai, India
Lancet Infect Dis 10:597-602. 2010..We investigated the prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in India, Pakistan, and the UK... - A multi-center blinded study on the efficiency of phenotypic screening methods to detect glycopeptide intermediately susceptible Staphylococcus aureus (GISA) and heterogeneous GISA (h-GISA)Andreas Voss
Radboud University Nijmegen Medical Centre, Nijmegen University Centre of Infectious Diseases, The Netherlands
Ann Clin Microbiol Antimicrob 6:9. 2007..To determine the true incidence of hGISA/GISA and its consequent clinical impact, methods must be defined that will reliably and reproducibly discriminate these resistant phenotypes from vancomycin susceptible S. aureus (VSSA)... - Clinically significant carbapenemases: an updateTimothy R Walsh
Department of Medical Microbiology, School of Medical Sciences, Cardiff University, Heath Park Hospital, Cardiff, UK
Curr Opin Infect Dis 21:367-71. 2008..To provide a brief synopsis of studies which have extended our understanding of carbapenem resistance in clinical isolates in terms of epidemiology, mechanism of action and genetic factors affecting their carriage and spread... - Evolution of the ISCR3 group of ISCR elementsMark A Toleman
School of Medicine, Department of Medical Microbiology, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
Antimicrob Agents Chemother 52:3789-91. 2008..The combined information is consistent with the descent from an ancestral ISCR element in a Xanthomonas-like organism... - Role of the 'cre/blr-tag' DNA sequence in regulation of gene expression by the Aeromonas hydrophila beta-lactamase regulator, BlrAMatthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 53:197-202. 2004.... - ISCR elements: novel gene-capturing systems of the 21st century?Mark A Toleman
Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Microbiol Mol Biol Rev 70:296-316. 2006..It appears that ISCR elements have now firmly established themselves within that regimen... - Combinatorial genetic evolution of multiresistanceTimothy R Walsh
Department of Molecular and Cellular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
Curr Opin Microbiol 9:476-82. 2006.... - Molecular analysis of the sequences surrounding blaOXA-45 reveals acquisition of this gene by Pseudomonas aeruginosa via a novel ISCR element, ISCR5Hongyang Li
Department of Medical Microbiology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
Antimicrob Agents Chemother 53:1248-51. 2009..The gene is located between nonidentical repeats of a new ISCR element, ISCR5, which is likely responsible for its acquisition. Sequence analysis indicates that ISCR5 is a chimera of ISCR3 and ISCR16... - Analysis of AmpC beta-lactamase expression and sequence in biochemically atypical ceftazidime-resistant Enterobacteriaceae from paediatric patientsMatthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 53:584-91. 2004..To analyse the variation of ampC beta-lactamase gene sequence and expression in biochemically atypical Enterobacteriaceae isolates, and to identify them definitively... - Common regions e.g. orf513 and antibiotic resistance: IS91-like elements evolving complex class 1 integronsMark A Toleman
Bristol Centre for Antimicrobial Research and Evaluation (BCARE, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk Bristol BS8 1TD, UK
J Antimicrob Chemother 58:1-6. 2006..In this article, we provide a brief description of these new and clinically important mobile elements, and how they are able to mobilize antibiotic resistance genes... - blaVIM-2-harboring integrons isolated in India, Russia, and the United States arise from an ancestral class 1 integron predating the formation of the 3' conserved sequenceMark A Toleman
Department of Medical Microbiology, University of Cardiff, Heath Park, Cardiff CF14 4XN, United Kingdom
Antimicrob Agents Chemother 51:2636-8. 2007..These unusual structures are likely to have arisen from an ancestral integron predating the formation of the 3' conserved sequence... - Combinatorial events of insertion sequences and ICE in Gram-negative bacteriaMark A Toleman
Department of Infection, Immunity and Biochemistry, Cardiff University, Heath Hospital, Heath Park Campus, Cardiff, UK
FEMS Microbiol Rev 35:912-35. 2011.... - The emergence of pan-resistant Gram-negative pathogens merits a rapid global political responseTimothy R Walsh
Section of Medical Microbiology, 6th Floor Main Building, IIB, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
J Antimicrob Chemother 67:1-3. 2012.... - A new approach to the inhibition of metallo-beta-lactamasesJames Spencer
Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
Angew Chem Int Ed Engl 45:1022-6. 2006 - Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence studyTimothy R Walsh
Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
Lancet Infect Dis 11:355-62. 2011..We therefore measured the prevalence of the NDM-1 gene in drinking water and seepage samples in New Delhi... - Genetic and biochemical characterization of a novel metallo-?-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, LibyaAllaaeddin El Salabi
Cardiff University, Cardiff, United Kingdom
Antimicrob Agents Chemother 56:2241-5. 2012..The K(m) values were more similar to those of GIM-1 than those of DIM-1, with the overall k(cat)/K(m) values being lower than those for GIM-1 and DIM-1... - Genetic linkage of the penicillinase gene, amp, and blrAB, encoding the regulator of beta-lactamase expression in Aeromonas sppPannika Niumsup
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Antimicrob Chemother 51:1351-8. 2003..The same hierarchy is seen following beta-lactam challenge of A. hydrophila T429125, and correlates with the number of blr-tag sequences (TTCAC) found upstream of each beta-lactamase gene: ampH (one), cepH (two) and imiH (three)... - Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophiliaMatthew B Avison
Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 49:387-9. 2002..The frequency of isolating type 3 mutants is c. 10(-9), however, implying that there is a significant overlap between the regulatory mechanisms... - Emerging metallo-beta-lactamase-mediated resistances: a summary report from the worldwide SENTRY antimicrobial surveillance programThomas R Fritsche
Jones Microbiology Institute Laboratories, North Liberty, IA 52317, USA
Clin Infect Dis 41:S276-8. 2005.... - Integrons containing the VIM-2 metallo-beta-lactamase gene among imipenem-resistant Pseudomonas aeruginosa strains from different Chinese hospitalsYun-song Yu
Infectious Disease Department, The 1st Affiliated Hospital, Medical School, Zhejiang University, The Key Laboratory of the Infectious Diseases of Public Health Ministry, Hangzhou, Zhejiang, China
J Clin Microbiol 44:4242-5. 2006..Fourteen isolates were confirmed to contain the VIM-2 metallo-beta-lactamase gene. Twelve isolates harbored two kinds of class 1 integron, containing both VIM-2- and aminoglycoside-resistant genes... - Effects of phenotype and genotype on methods for detection of extended-spectrum-beta-lactamase-producing clinical isolates of Escherichia coli and Klebsiella pneumoniae in NorwayStåle Tofteland
Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
J Clin Microbiol 45:199-205. 2007..coli strains. The relatively high proportion of ESBL-producing E. coli organisms with a low ceftazidime MIC in Norway emphasizes that cefpodoxime alone or both cefotaxime and ceftazidime should be used as substrates for ESBL detection... - Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospitalRodrigo E Mendes
Laboratório Especial de Microbiologia Clínica and Laboratório ALERTA, Division of Infectious Disease, Federal University of Sao Paulo, Sao Paulo, Brazil
Antimicrob Agents Chemother 51:2611-4. 2007..This report describes the ability of nonfermentative nosocomial pathogens to acquire and disseminate antimicrobial resistance determinants... - Dissemination of CTX-M-15 beta-lactamase genes carried on Inc FI and FII plasmids among clinical isolates of Escherichia coli in a university hospital in Istanbul, TurkeyNevriye Gonullu
Department of Microbiology and Clinical Microbiology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul 34303, Turkey
J Clin Microbiol 46:1110-2. 2008..Plasmid typing of transconjugates carrying bla(CTX-M-15) showed that most isolates belonged to the Inc/rep FII group but that one isolate also belonged to the FI group... - The AmpC phenotype in Norwegian clinical isolates of Escherichia coli is associated with an acquired ISEcp1-like ampC element or hyperproduction of the endogenous AmpCBjørg Haldorsen
Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
J Antimicrob Chemother 62:694-702. 2008..The aim of the study was to examine resistance mechanisms associated with an AmpC phenotype in Norwegian clinical isolates of Escherichia coli... - Complete Sequence of p07-406, a 24,179-base-pair plasmid harboring the blaVIM-7 metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United StatesHongyang Li
Department of Cellular Molecular Medicine, University of Bristol, Bristol BS8 1TD, United Kingdom
Antimicrob Agents Chemother 52:3099-105. 2008..This is the first plasmid to be sequenced carrying an MBL gene and highlights the amelioration of DNA segments from disparate origins, most noticeably from plant pathogens... - Evolution of an integron carrying blaVIM-2 in Eastern Europe: report from the SENTRY Antimicrobial Surveillance ProgramTimothy R Walsh
Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 52:116-9. 2003..This appears to be the first report of a metallo-beta-lactamase gene arising from a pathogenic strain in Eastern Europe... - Global emergence of trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genesMark A Toleman
School of Medicine at Cardiff University, Cardiff, Wales, U K
Emerg Infect Dis 13:559-65. 2007..maltophilia and are geographically widespread, findings that reinforce the need for ongoing resistance surveillance... - Metallo-beta-lactamases: the quiet before the storm?Timothy R Walsh
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
Clin Microbiol Rev 18:306-25. 2005..Their rapid dissemination is worrisome and necessitates the implementation of not just surveillance studies but also metallo-beta-lactamase inhibitor studies securing the longevity of important anti-infectives... - Functional characterization of OXA-57, a class D beta-lactamase from Burkholderia pseudomalleiKaren E Keith
Department of Biological Sciences, CMMI, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom
Antimicrob Agents Chemother 49:1639-41. 2005..Comparative kinetic analyses of wild-type and mutant forms of B. pseudomallei OXA-57 are reported. Implications of these data for beta-lactam resistance and the proposed role of Ser-104 in beta-lactam hydrolysis are discussed... - Emerging epidemic of metallo-beta-lactamase-mediated resistancesRonald N Jones
Diagn Microbiol Infect Dis 51:77-84. 2005 - Molecular characterization of a beta-lactamase gene, blaGIM-1, encoding a new subclass of metallo-beta-lactamaseMariana Castanheira
Disciplina de Doencas Infecciosas e Parasitarias, Universidade Federal de Sao Paulo, Brazil
Antimicrob Agents Chemother 48:4654-61. 2004..GIM-1 appears to be a unique MbetaL, which is located in a distinct integron structure, and represents the fourth subclass of mobile MbetaL enzymes to be characterized... - Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance ProgramRodrigo E Mendes
Disciplina de Doencas Infecciosas e Parasitarias, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Antimicrob Agents Chemother 48:4693-702. 2004..36 microM(-1) . s(-1)). This report further emphasizes the spread of metallo-beta-lactamase genes and their close association with various aminoglycoside resistance genes... - Genetic characterization of a novel metallo-beta-lactamase gene, blaIMP-13, harboured by a novel Tn5051-type transposon disseminating carbapenemase genes in Europe: report from the SENTRY worldwide antimicrobial surveillance programmeMark A Toleman
Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 52:583-90. 2003..The isolate was resistant to all antibiotics except amikacin, and displayed an imipenem MIC of 64 mg/L that decreased to 8 mg/L in the presence of EDTA. The resistance determinant was investigated... - Italian metallo-beta-lactamases: a national problem? Report from the SENTRY Antimicrobial Surveillance ProgrammeMark A Toleman
Department of Pathology and Microbiology, University of Bristol, Bristol, UK The JONES Group JMI Laboratories, North Liberty, IA, USA
J Antimicrob Chemother 55:61-70. 2005.... - Molecular and biochemical characterization of OXA-45, an extended-spectrum class 2d' beta-lactamase in Pseudomonas aeruginosaMark A Toleman
Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, United Kingdom
Antimicrob Agents Chemother 47:2859-63. 2003..Biochemically OXA-45 is most similar to OXA-18 in its substrate profile and inhibition by clavulanic acid and is a member of the 2d' class of beta-lactamases... - Biochemical characterization of the acquired metallo-beta-lactamase SPM-1 from Pseudomonas aeruginosaTanya A Murphy
Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, United Kingdom
Antimicrob Agents Chemother 47:582-7. 2003.... - Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineagesRobin A Howe
Southmead Hospital, Bristol, United Kingdom
Emerg Infect Dis 10:855-7. 2004..Increasing antimicrobial resistance in genetically distinct pandemic clones may lead to MRSA infections that will become increasingly difficult to treat... - Dissemination and diversity of metallo-beta-lactamases in Latin America: report from the SENTRY Antimicrobial Surveillance ProgramHelio S Sader
The JONES Group JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA, USA
Int J Antimicrob Agents 25:57-61. 2005..The emergence and dissemination of mobile MbetaL-producing isolates represent an alarming factor for increasing resistance to carbapenems in several medical centres evaluated by the SENTRY Program in Latin America... - Molecular characterization of SPM-1, a novel metallo-beta-lactamase isolated in Latin America: report from the SENTRY antimicrobial surveillance programmeMark A Toleman
Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, UK
J Antimicrob Chemother 50:673-9. 2002..The predicted molecular weight of the protein was 27 515 Da, significantly higher than that of IMP (25 041 Da) or VIM (25 322 Da). SPM-1 possesses a unique loop of 23 residues that accounts for the higher molecular mass... - First isolation of bla(VIM-2) in Latin America: report from the SENTRY Antimicrobial Surveillance ProgramRodrigo E Mendes
Antimicrob Agents Chemother 48:1433-4. 2004 - Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptidesAyman Hawrani
Department of Cellular and Molecular Medicine, Bristol University, Bristol BS8 1TD, United Kingdom
J Biol Chem 283:18636-45. 2008..We highlight a significant role for tryptophan in promoting binding of amphipathic helical peptides to neutral bilayers, augmenting the arsenal of strategies to reduce mammalian toxicity in antimicrobial peptides... - Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamasesJohn D Buynak
Department of Chemistry, Southern Methodist University, Dallas, TX 75275 0314, USA
Bioorg Med Chem Lett 14:1299-304. 2004..Selected (mercaptomethyl)penicillinates are shown to inactivate both metallo- and serine-beta-lactamases and to display synergism with piperacillin against beta-lactamase producing strains... - Pseudomonas aeruginosa strains harbouring an unusual blaVIM-4 gene cassette isolated from hospitalized children in Poland (1998-2001)Jan Patzer
The Children's Memorial Health Institute, Warsaw, Poland
J Antimicrob Chemother 53:451-6. 2004.... - blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United StatesMark A Toleman
Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, United Kingdom
Antimicrob Agents Chemother 48:329-32. 2004..This is the first report of a mobile metallo-beta-lactamase gene, bla(VIM-7), being detected within the United States... - The prevalence and mechanisms of vancomycin resistance in Staphylococcus aureusTimothy R Walsh
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, United Kingdom
Annu Rev Microbiol 56:657-75. 2002..There may be many different ways in which strains achieve this endpoint. Current knowledge and theories are summarized... - Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testingTimothy R Walsh
University of Bristol, United Kingdom
J Clin Microbiol 40:2755-9. 2002..The Etest MBL strip appears to be an acceptable diagnostic reagent to detect metallo-beta-lactamase phenotypes in the clinical microbiology laboratory... - Antimicrobial susceptibility and epidemiology of a worldwide collection of Chryseobacterium spp: report from the SENTRY Antimicrobial Surveillance Program (1997-2001)Jeffrey T Kirby
The JONES Group/JMI Laboratories, North Liberty, Iowa, USA
J Clin Microbiol 42:445-8. 2004..0% susceptibility) followed by rifampin (MIC(90), 2 microg/ml and 85.7% susceptibility). Trimethoprim-sulfamethoxazole, ciprofloxacin, and piperacillin-tazobactam also showed reasonable activity; vancomycin showed poor potency... - Emergence of the extended-spectrum beta-lactamase GES-1 in a Pseudomonas aeruginosa strain from Brazil: report from the SENTRY antimicrobial surveillance programMariana Castanheira
Antimicrob Agents Chemother 48:2344-5. 2004 - Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobriaPatrick A Crawford
Department of Chemistry and Biochemistry, 112 Hughes Hall, Miami University, Oxford, OH 45056, USA
Protein Expr Purif 36:272-9. 2004..This over-expression protocol now allows for detailed spectroscopic and mechanistic studies on ImiS as well as site-directed mutants of ImiS to be prepared for future structure/function studies... - Evolution and dissemination of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae: epidemiology and molecular report from the SENTRY Antimicrobial Surveillance Program (1997-2003)Joseph R DiPersio
Summa Health System, Department of Pathology, Akron, OH, USA
Diagn Microbiol Infect Dis 51:1-7. 2005..pneumoniae clones that have the ability to cause sustained epidemic outbreaks in US medical centers... - Reduced expression of the atl autolysin gene and susceptibility to autolysis in clinical heterogeneous glycopeptide-intermediate Staphylococcus aureus (hGISA) and GISA strainsMandy Wootton
Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular and Molecular Medicine, Medical Sciences, University of Bristol, Bristol BS1 8TD, UK
J Antimicrob Chemother 56:944-7. 2005..To assess a link between resistance to Triton X-100 induced autolysis (TIA) and lowered atl expression in a collection of clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heterogeneous GISA (hGISA)... - Analysis of Salmonella spp. with resistance to extended-spectrum cephalosporins and fluoroquinolones isolated in North America and Latin America: report from the SENTRY Antimicrobial Surveillance Program (1997-2004)Douglas J Biedenbach
JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
Diagn Microbiol Infect Dis 54:13-21. 2006..No QRDR trends over time were detected in North America, but increased resistance was observed in Latin America... - Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamasesTanya A Murphy
Department of Cellular and Molecular Medicine, University of Bristol School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
J Mol Biol 357:890-903. 2006..We further predict that SPM-1 possesses the capacity to evolve variants of enhanced catalytic activity by point mutations altering geometry and hydrogen bonding in the vicinity of the second Zn2+ site... - Characterization of fluoroquinolone-resistant beta-hemolytic Streptococcus spp. isolated in North America and Europe including the first report of fluoroquinolone-resistant Streptococcus dysgalactiae subspecies equisimilis: report from the SENTRY AntimicrDouglas J Biedenbach
JMI Laboratories, North Liberty, IA 52317, USA
Diagn Microbiol Infect Dis 55:119-27. 2006.... - Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamasesAlan M Simm
Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK
Biochem J 387:585-90. 2005..Docking experiments support the conclusion that bulgecin A co-ordinates to the zinc II site in metallo-beta-lactamases via the terminal sulphonate group on the sugar moiety... - Comparative bactericidal activities of daptomycin and vancomycin against glycopeptide-intermediate Staphylococcus aureus (GISA) and heterogeneous GISA isolatesMandy Wootton
Bristol Centre for Antimicrobial Research and Evaluation, Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, United Kingdom
Antimicrob Agents Chemother 50:4195-7. 2006..For all isolates, the daptomycin MIC50 and MIC90 are four times lower and the log drops in viable counts at 6 h and 24 h are significantly greater than those for vancomycin... - Pharmacodynamics of ceftazidime plus the serine beta-lactamase inhibitor AM-112 against Escherichia coli containing TEM-1 and CTX-M-1 beta-lactamasesKaren E Bowker
Bristol Centre for Antimicrobial Research and Evaluation, North Bristol NHS Trust, Department of Medical Microbiology, Southmead Hospital, Westbury on Trym, Bristol, BS10 5NB United Kingdom
Antimicrob Agents Chemother 48:4482-4. 2004..Ceftazidime alone was less effective than ceftazidime plus AM-112, and a single dose was more effective than three fractionated doses... - A multicenter study evaluating the current strategies for isolating Staphylococcus aureus strains with reduced susceptibility to glycopeptidesMandy Wootton
NPHS Microbiology Cardiff, University Hospital Wales, Cardiff, United Kingdom
J Clin Microbiol 45:329-32. 2007..MET exhibited the least interlaboratory variation. It is essential that laboratories use appropriate methods to detect GISA/hGISA strains so that the prevalence and clinical importance of these strains can be assessed properly... - Nosocomial outbreak of CTX-M-15-producing E. coli in NorwayUmaer Naseer
Reference Centre for Detection of Antimicrobial Resistance K res, Department of Microbiology and Infection Control, University Hospital of Northern Norway, Norway
APMIS 115:120-6. 2007..The outbreak emphasises the epidemic potential of multiple-antibiotic-resistant CTX-M-15-producing E. coli also in a country with low antibiotic usage and low prevalence of antimicrobial resistance... - hGISA: seek and ye shall findRobin A Howe
Lancet 364:500-1. 2004 - Characterization of monomeric L1 metallo-beta -lactamase and the role of the N-terminal extension in negative cooperativity and antibiotic hydrolysisAlan M Simm
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Biol Chem 277:24744-52. 2002..These data indicate that while the N terminus of L1 is not essential for beta-lactam hydrolysis, it is clearly important to its activity and substrate specificity...