Research Topics
| Anne E RosserSummaryAffiliation: Cardiff University Country: UK Publications
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Detail Information
Publications
Staging and preparation of human fetal striatal tissue for neural transplantation in Huntington's diseaseA E Rosser
School of Biosciences, Cardiff University, PO Box 911, Museum Av, Cardiff CF10 3US, Wales, UK
Cell Transplant 12:679-86. 2003....- Stem cell transplantation for neurodegenerative diseasesAnne E Rosser
Department of Neurology, School of Medicine, Cardiff University, Heath Park, UK
Curr Opin Neurol 20:688-92. 2007..To review recent developments in the application of stem cells for transplantation therapies in neurodegenerative diseases... - Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475A E Rosser
School of Biosciences, Cardiff University, Museum Avenue Box 911, Cardiff CF10 3US, UK
J Neurol Neurosurg Psychiatry 73:678-85. 2002.... - Neural transplantation in patients with Huntington's diseaseAnne E Rosser
School of Biosciences, Cardiff University, Cardiff, UK
CNS Drugs 17:853-67. 2003..To date, these clinical studies have demonstrated the feasibility and safety of transplantation in this condition, but it will require several more years yet before the efficacy of the procedure can be confidently established... - EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNSClaire M Kelly
School of Biosciences, Brain Repair Group, Cardiff University, Biomedical Science Building, Museum Avenue, P.O. Box 911, Cardiff CF1 3US, UK
Brain Res Bull 68:83-94. 2005..The effect of varying the concentration of EGF was assessed using mouse ENPs... - Striatal graft projections are influenced by donor cell type and not the immunogenic backgroundClaire M Kelly
Brain Repair Group, School of Biosciences, Museum Avenue, Cardiff, CF10 3US, UK
Brain 130:1317-29. 2007.... - Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppressionClaire M Kelly
Cardiff University, UK
Nat Methods 6:271-3. 2009.... - Cell therapy in Huntington's diseaseStephen B Dunnett
School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, United Kingdom
NeuroRx 1:394-405. 2004..Pilot and experimental clinical trials of several approaches are now also underway, and the alternative strategies are compared... - Clinical translation of cell transplantation in the brainStephen B Dunnett
School of Biosciences, Cardiff University, Cardiff, South Wales, UK
Curr Opin Organ Transplant 16:632-9. 2011.... - Pharmaceutical, cellular and genetic therapies for Huntington's diseaseOlivia J Handley
The Brain Repair Group, School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Clin Sci (Lond) 110:73-88. 2006..These new prospects offer hope for delaying and possibly halting this debilitating disease... - Medium spiny neurons for transplantation in Huntington's diseaseClaire M Kelly
Brain Repair Group, School of Biosciences, Museum Avenue, Cardiff University, Cardiff CF10 3AX, Wales, UK
Biochem Soc Trans 37:323-8. 2009.... - Stem cell transplantation for Huntington's diseaseStephen B Dunnett
The Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, UK
Exp Neurol 203:279-92. 2007.... - Cell-based treatments for huntington's diseaseStephen B Dunnett
Brain Repair Group, Schools of Biosciences and Medicine, Cardiff University, Cardiff, Wales, UK
Int Rev Neurobiol 98:483-508. 2011.... - Cell transplantation for Huntington's disease Should we continue?Stephen B Dunnett
Cardiff University, Cardiff, Wales, UK
Brain Res Bull 72:132-47. 2007.... - The survival of neural precursor cell grafts is influenced by in vitro expansionRike Zietlow
School of Biosciences, Cardiff University, UK
J Anat 207:227-40. 2005..This has implications for the potential use of these cells for neural transplantation strategies... - Can directed activity improve mobility in Huntington's disease?M E Busse
Cardiff University, School of Health Care Studies, Department of Physiotherapy, Ty Dewi Sant, Heath Park, UK
Brain Res Bull 72:172-4. 2007.... - Challenges facing quantification of rat locomotion along beams of varying widthsJ K Madete
Research Office, School of Engineering, Cardiff University, Queens Building, Cardiff CF24 3AA, UK
Proc Inst Mech Eng H 224:1257-65. 2010..Such measurements can be compared with human motion analysis to explore correlations between the animal model and human behaviour, which is an important step for translational medicine... - Human stem cells for CNS repairRike Zietlow
Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
Cell Tissue Res 331:301-22. 2008..Success will depend on careful investigation in experimental models to enable us to understand not just the practicalities of stem cell use, but also the underlying biological principles... - Potential cellular and regenerative approaches for the treatment of Parkinson's diseaseEmma L Lane
Brain Repair Group, School of Biosciences, Cardiff University, CF10 3US, UK
Neuropsychiatr Dis Treat 4:835-45. 2008.... - The effects of various concentrations of FGF-2 on the proliferation and neuronal yield of murine embryonic neural precursor cells in vitroClaire M Kelly
Brain Repair Group, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
Cell Transplant 12:215-23. 2003..However, once adjustments were made for the amount of expansion at each dose, final neuronal yield was maximum at the highest concentration of FGF-2 used (20 ng/ml)... - Physical therapy intervention for people with Huntington diseaseMonica E Busse
Department of Physiotherapy, School of Health Care Studies, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom
Phys Ther 88:820-31. 2008..The objective of this study was to characterize current physical therapist practice for people with HD, thus informing the development of standardized clinical care and future research studies... - Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington's diseaseMonica E Busse
Department of Physiotherapy, School of Healthcare Studies, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff, CF14 4XN, UK
J Neurol 255:1534-40. 2008..Muscle strength was evaluated using a hand-held dynamometer. Reliability and validity in people with HD were determined... - Mobility and falls in people with Huntington's diseaseM E Busse
Department of Physiotherapy, School of Healthcare Studies, Cardiff University, Ty Dewi Sant, Heath Park, Cardiff CF14 4XN, UK
J Neurol Neurosurg Psychiatry 80:88-90. 2009..The aim of this study was to estimate the frequency of falls in people with Huntington's disease (HD) and make a preliminary assessment of tools appropriate for assessing the risk of falling... - Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cellsAlexis J Joannides
Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
Brain 130:1263-75. 2007..Controlled manipulation of environmental signals appropriate to the pathological specificity of the targeted disease will be necessary in the design of therapeutic stem cell-based strategies... - Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNSCarrie B Hurelbrink
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
Eur J Neurosci 15:1255-66. 2002.... - The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's diseaseRichard J E Armstrong
Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, United Kingdom
Exp Neurol 175:98-111. 2002.... - Transplantation of expanded neural precursor cells from the developing pig ventral mesencephalon in a rat model of Parkinson's diseaseRichard J E Armstrong
Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, CB2 2PY, Cambridge, UK
Exp Brain Res 151:204-17. 2003..Furthermore, derivation of ENPs from the VM at the time of normal dopaminergic neurogenesis is inadequate to ensure functional dopaminergic grafts on transplantation... - GABAergic immunoreactivity is predominant in neurons derived from expanded human neural precursor cells in vitroMeena Jain
Cambridge University Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
Exp Neurol 182:113-23. 2003..Such characterisation is important in the process of learning how to manipulate the neuronal phenotype of these cells... - Migration and differentiation of transplanted human neural precursor cellsMeena Jain
Cambridge University Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, UK
Neuroreport 14:1257-62. 2003.... - Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: implications for clinical trials in Huntington's diseaseCarrie B Hurelbrink
Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
Cell Transplant 12:687-95. 2003.... - Cell transplantation for Huntington's diseaseAnne E Rosser
Lancet Neurol 5:284-5. 2006 - Verbal fluency in Huntington's disease: a longitudinal analysis of phonemic and semantic clustering and switchingAileen K Ho
Cambridge Centre for Brain Repair, University of Cambridge, UK
Neuropsychologia 40:1277-84. 2002..Hence, phonemic switching alone drove verbal fluency performance and this selective impairment can be explained by the progressive involvement of frontostriatal circuitry in the natural progression of HD... - A case of unilateral neglect in Huntington's diseaseAileen K Ho
Cambridge Centre for Brain Repair, Cambridge University, Forvie Site, Robinson Way, Cambridge, UK
Neurocase 9:261-73. 2003..However, as this was only apparent at a threshold below that normally considered acceptable (due to the resulting number of false positives), this possible account of the neglect must be viewed very cautiously... - Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET studyNicola Pavese
MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
Brain 126:1127-35. 2003..This probably reflects both contributions from other affected brain structures and high variance in these measures...