Research Topics
Genomes and Genes | Julian LewisSummaryAffiliation: Cancer Research UK Country: UK Publications
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Publications
Notch signaling, the segmentation clock, and the patterning of vertebrate somitesJulian Lewis
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
J Biol 8:44. 2009..The parts it plays in the early operation of the segmentation clock and the later definition and differentiation of the somites are beginning to be understood...- Planar cell polarity in the inner ear: how do hair cells acquire their oriented structure?Julian Lewis
Vertebrate Development Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
J Neurobiol 53:190-201. 2002..The mechanism creating the staircase pattern of stereocilium lengths is unknown, but could involve regulation of stereocilium growth by Ca(2+) ions entering via transduction channels... - MAZe: a tool for mosaic analysis of gene function in zebrafishRussell T Collins
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, UK
Nat Methods 7:219-23. 2010..As an alternative to heat shock, we introduced Cre under a tissue-specific promoter in MAZe fish to generate clones in a designated tissue... - Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillatorJulian Lewis
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
Curr Biol 13:1398-408. 2003.... - Deciphering the somite segmentation clock: beyond mutants and morphantsJulian Lewis
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
Dev Dyn 236:1410-5. 2007..Some progress is being made in these directions... - Setting the tempo in development: an investigation of the zebrafish somite clock mechanismFrancois Giudicelli
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
PLoS Biol 5:e150. 2007.... - Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundariesErtugrul M Ozbudak
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
PLoS Genet 4:e15. 2008.... - DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clockGavin J Wright
Vertebrate Development Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London, UK
Development 138:2947-56. 2011.... - Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner earNicolas Daudet
Vertebrate Development Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 134:2369-78. 2007..The positive feedback maintains Notch activation and thereby preserves and perhaps extends the prosensory state, leading eventually to the development of normal sensory patches... - Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiationNicolas Daudet
Vertebrate Development Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 132:541-51. 2005..Subsequently, Notch signalling within each such patch mediates lateral inhibition, restricting the proportion of cells that differentiate as hair cells so as to generate the fine-grained mixture of hair cells and supporting cells... - Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesisJonathan D Leslie
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 134:839-44. 2007..Thus, Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf... - Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell systemDespina Stamataki
Vertebrate Development Laboratory, Cancer Research United Kingdom London Research Institute, London, United Kingdom
PLoS ONE 6:e24484. 2011..A simple mathematical model shows how, instead, Notch signaling may simultaneously govern the commitment to be secretory and the choice between alternative modes of secretory differentiation... - Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestineCecile Crosnier
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 132:1093-104. 2005..These findings demonstrate the central role of Notch signalling in the gut stem-cell system and establish the zebrafish as a model for study of the mechanisms controlling renewal of gut epithelium... - Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner earRachael Brooker
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 133:1277-86. 2006..Our findings confirm that Notch signalling in the ear has distinct prosensory and lateral-inhibitory functions, for which different ligands are primarily responsible... - From signals to patterns: space, time, and mathematics in developmental biologyJulian Lewis
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Science 322:399-403. 2008.... - Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish developmentGavin J Wright
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 131:5659-69. 2004..They do, however, show an anomalous distribution of Rohon-Beard neurons in the dorsal neural tube, suggesting that the Delta-MAGI interaction may play some part in the control of neuron migration... - The vertebrate segmentation clockFrancois Giudicelli
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Curr Opin Genet Dev 14:407-14. 2004.... - Organizing cell renewal in the intestine: stem cells, signals and combinatorial controlCecile Crosnier
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Nat Rev Genet 7:349-59. 2006.... - Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-flamingo-1 proteinAlexander Davies
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom
Dev Dyn 233:998-1005. 2005.... - Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birdsNicolas Daudet
Vertebrate Development Laboratory, Cancer Research UK, London, UK
Dev Biol 326:86-100. 2009..Therefore, signaling through Notch is not required for SC quiescence in the healthy epithelium or to initiate HC regeneration after damage. Rather, Notch prevents SCs from regenerating excessive HCs after damage... - Notch activity is required to maintain floorplate identity and to control neurogenesis in the chick hindbrain and spinal cordIsabelle Le Roux
London Research Institute, Cancer Research UK, London, UK
Int J Dev Biol 47:263-72. 2003.... - Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringeXuehui Qiu
Laboratory of Developmental Signalling and Patterning, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
Dev Dyn 231:621-30. 2004.... - beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiationDörthe Jülich
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
Dev Biol 286:391-404. 2005.... - Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by DeltaMotoyuki Itoh
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
Dev Cell 4:67-82. 2003..This facilitates intramembranous cleavage of the remaining Notch receptor, release of the Notch intracellular fragment, and activation of target genes in neighboring cells... - Control of segment number in vertebrate embryosCéline Gomez
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Nature 454:335-9. 2008..In snake embryos, however, the segmentation clock rate is much faster relative to developmental rate than in other amniotes, leading to a greatly increased number of smaller-sized somites... - Instability of Hes7 protein is crucial for the somite segmentation clockHiromi Hirata
Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
Nat Genet 36:750-4. 2004..We simulated this effect mathematically using a direct autorepression model. Thus, instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock...