Detail Information
Publications
Glycolytic enzymes can modulate cellular life spanHiroshi Kondoh
Wolfson Institute for Biomedical Research, University College London, London Research Institute, London, United Kingdom
Cancer Res 65:177-85. 2005..Because wild-type p53 down-regulates PGM, mutation of p53 can facilitate immortalization via effects on PGM levels and glycolysis...
Cellular life span and the Warburg effectHiroshi Kondoh
Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
Exp Cell Res 314:1923-8. 2008..Discovery of a novel regulatory mechanism for such a metabolic shift might be essential for the future development of cancer diagnosis and anti-cancer therapy...
A high glycolytic flux supports the proliferative potential of murine embryonic stem cellsHiroshi Kondoh
Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Antioxid Redox Signal 9:293-9. 2007..The authors hypothesize that the naturally high glycolytic flux observed in murine ES cells can be responsible for their unlimited proliferative potential...
[Impact of metabolic shift on cellular lifespan]Hiroshi Kondoh
Nippon Ronen Igakkai Zasshi 44:198-200. 2007
