Research Topics
Species | Peter KarranSummaryAffiliation: Cancer Research UK Country: UK Publications
| Collaborators
|
Detail Information
Publications
Thiopurines, DNA damage, DNA repair and therapy-related cancerPeter Karran
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
Br Med Bull 79:153-70. 2006..The same enhanced reactivity may contribute to the increased risk of acute myeloid leukaemia and skin cancer in thiopurine-treated organ transplant patients...- Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancerPeter Karran
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK
Nat Rev Cancer 8:24-36. 2008..Understanding how thiopurines contribute to the development of cancer will facilitate clinical decisions about the potential risks to patients of long-term treatment for chronic inflammatory disorders... - Human mismatch repair, drug-induced DNA damage, and secondary cancerPeter Karran
Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK
Biochimie 85:1149-60. 2003..Here we review how MMR interacts with alkylating agent and thiopurine-induced DNA damage and suggest possible ways in which MMR defects may arise in therapy-related AML/MDS... - Reactive oxygen-mediated damage to a human DNA replication and repair proteinBeatriz Montaner
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
EMBO Rep 8:1074-9. 2007..Our findings identify oxidative damage to an important DNA replication and repair protein as a previously unrecognized hazard of acute oxidative stress... - Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiationXiaolin Ren
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
Nucleic Acids Res 38:1832-40. 2010..In agreement with this possibility, the antioxidant ascorbate protected DNA 6-TG against UVA oxidation and prevented the formation of G(SO3)... - Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVAQuentin Gueranger
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, EN6 3LD, UK
Nucleic Acids Res 39:5057-66. 2011..These findings suggest that the 6-TG/UVA combination might compromise DNA repair by sequestering essential proteins... - 6-Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cellsIlse Daehn
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
FEBS Lett 585:3941-6. 2011..Cells without mtDNA are less sensitive to killing by a combination of 6-TG and UVA than their mtDNA-containing counterparts, indicating that photochemical mtDNA 6-TG oxidation contributes to 6-TG-mediated UVA photosensitization... - Azathioprine and UVA light generate mutagenic oxidative DNA damageConal M Perrett
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
Science 309:1871-4. 2005..These findings may partly explain the prevalence of skin cancer in long-term survivors of organ transplantation... - Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesionsReto Brem
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
Nucleic Acids Res 37:1951-61. 2009..Since persistent transcription-blocking DNA lesions are associated with acute skin responses to sunlight and the development of skin cancer, our findings have implications for skin cancer in patients undergoing thiopurine therapy... - 8-oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSalphaPeter MacPherson
Cancer Research UK London Research Institute, Clare Hall Laboratories South Mimms, Herts, EN6 3LD, UK
Nucleic Acids Res 33:5094-105. 2005..These findings are consistent with a contribution of oxidative DNA damage to frameshifts. They also suggest how mismatch repair might reduce the burden of DNA 8-oxoG and prevent frameshift formation... - Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantationJudith Offman
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, United Kingdom
Blood 104:822-8. 2004..Identifying azathioprine as a risk factor for AML/MDS suggests that discontinuing the use of azathioprine as an immunosuppressant might reduce the incidence of posttransplantation AML/MDS... - Immune effector cells produce lethal DNA damage in cells treated with a thiopurineIlse Daehn
Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, United Kingdom
Cancer Res 69:2393-9. 2009..This bystander vulnerability of cells containing DNA 6-TG to oxidation by ROS generated by immune effector cells has implications for the long-term use of azathioprine in the management of inflammatory disorders... - Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiationReto Brem
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
DNA Repair (Amst) 10:869-76. 2011..Our findings suggest that sunlight-exposed skin of thiopurine treated patients may experience chronic photochemical DNA damage that requires constant intervention of the FA pathway... - Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndromeJudith Offman
Cancer Research UK London Research Institute, Mammalian DNA Repair Laboratory, Clare Hall Laboratories, South Mimms, Herts, United Kingdom EN6 3LD
Mol Cancer Res 3:251-60. 2005..Both genes were frequent targets for mutation in MSI+ cell lines and colorectal carcinomas. FANCD2 mutations were also common in MSI+ tAML/MDS, although NF1 mutations were not observed. A novel FANCD2 polymorphism was also identified... - UVA photosensitization of thiopurines and skin cancer in organ transplant recipientsNatalie R Attard
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
Photochem Photobiol Sci 11:62-8. 2012..Many of these photochemical DNA lesions are difficult for cells to deal with, and we review the evidence linking thiopurine immunosuppression with genome instability and the high incidence of skin cancer in organ transplant recipients... - Photo-oxidation of 6-thioguanine by UVA: the formation of addition products with low molecular weight thiol compoundsXiaolin Ren
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
Photochem Photobiol 86:1038-45. 2010.... - Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cellsOlivier Reelfs
King s College London, School of Medicine, Division of Genetics and Molecular Medicine, St John s Institute of Dermatology, London, SE1 9RT, UK
Nucleic Acids Res 39:9620-32. 2011..Cells defective in repairing (6-4) Py:Py DNA adducts or processing DNA crosslinks are extremely sensitive to S(4)TdR/UVA indicating that these lesions contribute significantly to S(4)TdR/UVA cytotoxicity... - DNA mismatch repair and acquired cisplatin resistance in E. coli and human ovarian carcinoma cellsAndrew Massey
Clare Hall Laboratories, London Research Institute, Cancer Research UK, South Mimms, EN6 3LD Herts, UK
DNA Repair (Amst) 2:73-89. 2003.... - XPC lymphoblastoid cells defective in the hMutSalpha DNA mismatch repair complex exhibit normal sensitivity to UVC radiation and normal transcription-coupled excision repair of DNA cyclobutane pyrimidine dimersKatsutoshi Kobayashi
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
DNA Repair (Amst) 3:649-57. 2004..We conclude efficient TCR does not depend on a functional hMutSalpha complex... - Vanillins--a novel family of DNA-PK inhibitorsStephen Durant
Mammalian DNA Repair, Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Herts, EN6 3LD, UK
Nucleic Acids Res 31:5501-12. 2003..The inhibition of NHEJ is consistent with the antimutagenic and other biological properties of vanillin, possibly altering the balance between DSB repair by NHEJ and homologous recombination... - Ambiguous coding is required for the lethal interaction between methylated DNA bases and DNA mismatch repairAndrew Massey
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, EN6 3LD, UK
DNA Repair (Amst) 1:275-86. 2002..We suggest that the ability of S4meT to produce a structurally acceptable base pair during replication underlies the absence of MMR-related death in cells treated with S4TdR... - Multiple forms of DNA damage caused by UVA photoactivation of DNA 6-thioguanineReto Brem
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
Photochem Photobiol 88:5-13. 2012..We discuss how this photochemical damage might contribute to the toxic effect of thiopurine/UVA treatment on cultured cells and to the high risk of skin cancer in thiopurine-treated patients... - Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndromeIda Casorelli
Istituto Superiore di Sanita, Laboratorio di Tossicologia Comparata, Rome, Italy
DNA Repair (Amst) 2:547-59. 2003..In view of the established relationship between drug resistance and mismatch repair defects, we suggest that selection for therapeutic drug resistance may contribute to the incidence of MSI(+) tAL/MDS... - Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instabilityShinya Oda
Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka 811 1395, Japan
Nucleic Acids Res 33:1628-36. 2005..The relationship between MSI and defective mismatch repair may be more complex than hitherto suspected... - Replication of 2-hydroxyadenine-containing DNA and recognition by human MutSalphaFlavia Barone
Unit of Experimental Carcinogenesis, Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
DNA Repair (Amst) 6:355-66. 2007..MutSalpha also recognized 2-OH-A located in a repeat sequence that mimics a frameshift intermediate... - 4-Thio-5-bromo-2'-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damageYao Zhong Xu
Department of Chemistry, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
Bioorg Med Chem Lett 14:995-7. 2004..3a has UV maximum absorption at 340 nm and can be incorporated into cellular DNA. The cells containing 3a become sensitive to UVA light, offering therapeutic potential for UVA-induced cell killing... - Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus statusOlivier Reelfs
Cancer Research UK, Institute for Cell and Molecular Science, Skin Tumour Laboratory, 4, Newark Street, London E1 2AT, United Kingdom
Mol Cancer Ther 6:2487-95. 2007..S(4)TdR/UVA offers a possible therapeutic intervention strategy that seems to be applicable to human papilloma virus-associated skin lesions... - Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA lightXiaohong Zhang
Department of Chemistry, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK
DNA Repair (Amst) 6:344-54. 2007..In cultured human cells, DNA damage produced by 6-TG and UVA treatment is associated with replication inhibition and provokes a p53-dependent DNA damage response... - Involvement of mismatch repair in transcription-coupled nucleotide excision repairKatsutoshi Kobayashi
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
Hum Cell 18:103-15. 2005..To date, in mammalian cells, there are conflicting evidences for the association of MMR with TCR pathway. The aim of this article is to provide a brief overview of the recent literature on this subject... - Structural and dynamic effects of single 7-hydro-8-oxoguanine bases located in a frameshift target DNA sequenceFlavia Barone
Department of Environment and Primary Prevention, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Roma, Rome, Italy
Biophys Chem 118:31-41. 2005..These constraints influenced the efficiency of primer extension by Klenow (exo(-)) DNA polymerase... - The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cellsMaria Teresa Russo
Chemical Carcinogenesis Unit, Istituto Superiore di Sanit, Rome, Italy
Mol Cell Biol 24:465-74. 2004..Our findings indicate that incorporation of oxidized purines from the dNTP pool may contribute significantly to the extreme genetic instability of MMR-defective human tumors... - The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP poolClaudia Colussi
Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanita, Rome, Italy
Curr Biol 12:912-8. 2002..Increased expression of MTH1 in MMR-defective cells significantly reduces steady-state and H(2)O(2)-induced DNA 8-oxoG levels. This reduction dramatically diminishes the spontaneous mutation rate of Msh2(-/-) MEFs...