Michaela Frye

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi Stem cell depletion through epidermal deletion of Rac1
    Salvador Aznar Benitah
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 309:933-5. 2005
  2. ncbi The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Curr Biol 16:971-81. 2006
  3. ncbi MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
    Fiona M Watt
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nat Rev Cancer 8:234-42. 2008
  4. ncbi Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
    Development 130:2793-808. 2003
  5. ncbi Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1
    Anneli Gebhardt
    Institute for Cell Biology, University of Marburg, 35033 Marburg, Germany
    J Cell Biol 172:139-49. 2006
  6. ncbi Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin
    Cristina Lo Celso
    Massachusetts General Hospital, Center for Regenerative Medicine, Boston, Massachusetts, USA
    Stem Cells 26:1241-52. 2008

Collaborators

Detail Information

Publications6

  1. ncbi Stem cell depletion through epidermal deletion of Rac1
    Salvador Aznar Benitah
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 309:933-5. 2005
    ..We conclude that a pleiotropic regulator of cell adhesion and the cytoskeleton plays a critical role in controlling exit from the stem cell niche and propose that Rac and Myc represent a global stem cell regulatory axis...
  2. ncbi The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Curr Biol 16:971-81. 2006
    ..In adult epidermis, Myc stimulates exit from the stem cell compartment, decreasing cell adhesion and, by an unknown mechanism, triggering proliferation of transit-amplifying cells...
  3. ncbi MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
    Fiona M Watt
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Nat Rev Cancer 8:234-42. 2008
    ....
  4. ncbi Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
    Michaela Frye
    Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
    Development 130:2793-808. 2003
    ....
  5. ncbi Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1
    Anneli Gebhardt
    Institute for Cell Biology, University of Marburg, 35033 Marburg, Germany
    J Cell Biol 172:139-49. 2006
    ..Our data show that regulation of cell adhesion is a major function of the Myc-Miz1 complex and suggest that it may contribute to Myc-induced exit from the epidermal stem cell compartment...
  6. ncbi Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin
    Cristina Lo Celso
    Massachusetts General Hospital, Center for Regenerative Medicine, Boston, Massachusetts, USA
    Stem Cells 26:1241-52. 2008
    ..Our studies provide evidence for a bipotential epidermal stem cell population in an in vitro model of human epidermal lineage selection and highlight the importance of Myc as a regulator of sebocyte differentiation...