Predrag Slijepcevic

Summary

Affiliation: Brunel University
Country: UK

Publications

  1. ncbi Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells
    Kalpana Gopalakrishnan
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
    Genome Integr 1:16. 2010
  2. ncbi Chinese hamster telomeres are comparable in size to mouse telomeres
    P Slijepcevic
    Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UK
    Cytogenet Cell Genet 85:196-9. 1999
  3. ncbi Defective Artemis causes mild telomere dysfunction
    Hemad Yasaei
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
    Genome Integr 1:3. 2010
  4. ncbi DNA damage response, telomere maintenance and ageing in light of the integrative model
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Mech Ageing Dev 129:11-6. 2008
  5. ncbi The role of DNA damage response proteins at telomeres--an "integrative" model
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosceinces, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, United Kingdom
    DNA Repair (Amst) 5:1299-306. 2006
  6. ncbi Telomere biology: integrating chromosomal end protection with DNA damage response
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Chromosoma 114:275-85. 2005
  7. ncbi Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells
    Ester Sapir
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
    Genome Integr 2:9. 2011
  8. ncbi Chromosome-specific telomeric associations in Chinese hamster embryonic cells
    P Slijepcevic
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, England
    Genes Chromosomes Cancer 28:98-105. 2000
  9. ncbi Is there a link between telomere maintenance and radiosensitivity?
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, United Kingdom
    Radiat Res 161:82-6. 2004
  10. ncbi Telomere length measurement by Q-FISH
    P Slijepcevic
    Department of Biological Sciences, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, UK
    Methods Cell Sci 23:17-22. 2001

Collaborators

  • Peter E Bryant
  • A T Natarajan
  • Y Xiao
  • M P Hande
  • Penny A Jeggo
  • Maria A Blasco
  • Irena Szumiel
  • H Mozdarani
  • S D Bouffler
  • W Bodmer
  • E Cabuy
  • Hemad Yasaei
  • Erik Cabuy
  • H-P Wong
  • Suliman Al-Wahiby
  • Ester Sapir
  • Kalpana Gopalakrishnan
  • J McIlrath
  • Anastasia Nijnik
  • C Newton
  • S Al-Wahiby
  • Raquel Losada
  • Jackie Haines
  • S Modino
  • Sainu Ravindran
  • Yaghoub Gozaly-Chianea
  • Grace Kah Mun Low
  • Aloysius Poh Leong Ting
  • Prarthana Srikanth
  • Lisa Woodbine
  • Caterina Marchetti
  • Tariq Enver
  • Neil P Rodrigues
  • Richard J Cornall
  • Cong Liu
  • John I Bell
  • Sara Dawson
  • Alessandro Vindigni
  • Tanya L Crockford
  • Teresa Lambe
  • Christopher C Goodnow
  • Mohammad Ilyas
  • Hiu-Pak Wong
  • Hiu Pak Wong
  • B Koller
  • L Woodbine
  • Nirosha Suraweera
  • Andrew Silver
  • Ian Tomlinson
  • Oliver Sieber
  • Victoria Johnson
  • Kevin Pack
  • Margaret Coster
  • Jennifer Wilding
  • Vicente Goyanes
  • G Joksic
  • Chris Newton
  • Robert Newbold
  • C Finnegan
  • Terry Roberts
  • A Wojcik
  • R F Newbold
  • A C Riches
  • A Cuthbert
  • E Samper
  • A Thompson

Detail Information

Publications23

  1. ncbi Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells
    Kalpana Gopalakrishnan
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore
    Genome Integr 1:16. 2010
    ..abstract:..
  2. ncbi Chinese hamster telomeres are comparable in size to mouse telomeres
    P Slijepcevic
    Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UK
    Cytogenet Cell Genet 85:196-9. 1999
    ....
  3. ncbi Defective Artemis causes mild telomere dysfunction
    Hemad Yasaei
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
    Genome Integr 1:3. 2010
    ..Since a mouse study indicated that defective Artemis may cause telomere dysfunction we investigated the effects of defective Artemis on telomere maintenance in human cells...
  4. ncbi DNA damage response, telomere maintenance and ageing in light of the integrative model
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Mech Ageing Dev 129:11-6. 2008
    ..In line with this prediction between 87 and 90% of mouse and human models of premature ageing show this dual phenotype. It is concluded that the integrative model is consistent with the "network" theory of ageing...
  5. ncbi The role of DNA damage response proteins at telomeres--an "integrative" model
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosceinces, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, United Kingdom
    DNA Repair (Amst) 5:1299-306. 2006
    ....
  6. ncbi Telomere biology: integrating chromosomal end protection with DNA damage response
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Chromosoma 114:275-85. 2005
    ..In our model, a close association between telomeres and different DNA damage response factors is not an unexpected event, but rather a logical result of chromosomal integrity maintenance activities...
  7. ncbi Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells
    Ester Sapir
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK
    Genome Integr 2:9. 2011
    ..abstract:..
  8. ncbi Chromosome-specific telomeric associations in Chinese hamster embryonic cells
    P Slijepcevic
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, England
    Genes Chromosomes Cancer 28:98-105. 2000
    ..It appears that TAs in CHE cells may be reversible events. These results are discussed in light of current understanding of telomere biology...
  9. ncbi Is there a link between telomere maintenance and radiosensitivity?
    Predrag Slijepcevic
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, United Kingdom
    Radiat Res 161:82-6. 2004
    ..These results warrant further investigation to identify the extent to which these two phenotypes, namely radiosensitivity and telomere maintenance, are linked...
  10. ncbi Telomere length measurement by Q-FISH
    P Slijepcevic
    Department of Biological Sciences, Brunel University, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, UK
    Methods Cell Sci 23:17-22. 2001
    ..Principles of Q-FISH and its applications are briefly described in this article...
  11. ncbi Lack of spontaneous and radiation-induced chromosome breakage at interstitial telomeric sites in murine scid cells
    H-P Wong
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, UK
    Cytogenet Genome Res 104:131-6. 2004
    ..Therefore, our results indicate a previously unanticipated role of DNA-PKcs in chromatin organisation, which could contribute to the lack of ITS sensitivity to chromosome breakage in murine scid cells...
  12. ncbi Telomere length measurement in mouse chromosomes by a modified Q-FISH method
    H-P Wong
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, UK
    Cytogenet Genome Res 105:464-70. 2004
    ..Using this protocol we demonstrate that reproducible results can be obtained in a set of four different mouse cell lines. This method can be adapted so that any pair of mammalian cell lines can serve as an internal calibration standard...
  13. ncbi Telomere length abnormalities in mammalian radiosensitive cells
    J McIlrath
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, United Kingdom
    Cancer Res 61:912-5. 2001
    ..Telomere length abnormalities observed in radiosensitive cells suggest that these two phenotypes may be linked...
  14. ncbi Chromosomal aberrations involving telomeres in BRCA1 deficient human and mouse cell lines
    S Al-Wahiby
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Department of Biological Sciences, Brunel University, Uxbridge, UK
    Cytogenet Genome Res 109:491-6. 2005
    ..Our results reveal cytogenetic evidence of telomere dysfunction in BRCA1 deficient cells...
  15. ncbi Identification of subpopulations of cells with differing telomere lengths in mouse and human cell lines by flow FISH
    Erik Cabuy
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, United Kingdom
    Cytometry A 62:150-61. 2004
    ..The existence of cell subpopulations with differing telomere lengths was confirmed by Q-FISH. CONCLUSION: Our results underscore the importance of flow-FISH in telomere length analysis...
  16. ncbi Telomere shortening in mouse strains with constitutional chromosomal aberrations
    S Modino
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, UK
    Int J Radiat Biol 78:757-64. 2002
    ..This might have implications for understanding biological consequences or radiation-induced stable chromosomal aberrations...
  17. ncbi Shortened telomeres in murine scid cells expressing mutant hRAD54 coincide with reduction in recombination at telomeres
    Suliman Al-Wahiby
    Brunel Institute of Cancer Genetics and Pharmacogenomics, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Mutat Res 578:134-42. 2005
    ..e. telomere shortening and reduced recombination rates at telomeres, these results argue that telomere elongation in scid cells is a complex trait resulting from interactions between homologous recombination mechanisms and DNA-PKcs...
  18. ncbi Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines
    E Cabuy
    Brunel Institute of Cancer Genetics and Pharmacogenomics, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, UB8 3PH, United Kingdom
    Radiat Res 164:53-62. 2005
    ..Our results suggest that mechanisms that confer sensitivity to ionizing radiation may be linked with mechanisms that cause telomere dysfunction...
  19. ncbi BRCA1 knock-down causes telomere dysfunction in mammary epithelial cells
    E Cabuy
    Brunel Institute of Cancer Genetics and Pharmacogenomics, School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, UK
    Cytogenet Genome Res 122:336-42. 2008
    ..Therefore, this study suggests that BRCA1 knockdown in mammary epithelial cells causes telomere dysfunction...
  20. ncbi DNA repair is limiting for haematopoietic stem cells during ageing
    Anastasia Nijnik
    Henry Wellcome Building for Molecular Physiology, Oxford University, Oxford OX3 9DU, UK
    Nature 447:686-90. 2007
    ....
  21. ncbi Effect of Wortmannin on the repair profiles of DNA double-strand breaks in the whole genome and in interstitial telomeric sequences of Chinese hamster cells
    Raquel Losada
    , Complejo Hospitalario Universitario Juan Canalejo (CHUJC, As Xubias 84, , Spain
    Mutat Res 570:119-28. 2005
    ..These results suggest that there is an intragenomic heterogeneity in DSB repair, as well as in the effect of WM on this process...
  22. ncbi Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice
    Jackie Haines
    National Radiological Protection Board, Chilton, Didcot, Oxon OX11 ORQ, United Kingdom
    Proc Natl Acad Sci U S A 102:2868-73. 2005
    ..We propose that a modifier gene close to Apc or structural variation on chromosome 18 modifies polyp numbers in our mice, possibly by altering the frequency of WT Apc allele loss...