Ishita S Mehta

Summary

Affiliation: Brunel University
Country: UK

Publications

  1. ncbi Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts
    Ishita S Mehta
    Centre for Cell and Chromosome Biology, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, UB8 3PH, UK
    Genome Biol 11:R5. 2010
  2. ncbi Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells
    Ishita S Mehta
    Progeria Research Team, Centre for Cell and Chromosome Biology, Biosciences, School of Health Sciences and Social Care, Brunel University, West London, UB8 3PH, UK
    Genome Biol 12:R74. 2011
  3. ncbi Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?
    Ishita S Mehta
    Division of Biosciences, Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, School of Health Sciences and Social Care, Brunel University, Uxbridge, UK
    Biochem Soc Trans 36:1384-8. 2008
  4. ncbi Progeria, the nucleolus and farnesyltransferase inhibitors
    Ishita S Mehta
    Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge UB8 3PH, UK
    Biochem Soc Trans 38:287-91. 2010
  5. ncbi Alterations to nuclear architecture and genome behavior in senescent cells
    Ishita S Mehta
    Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Biosciences, School of Health Sciences and Social Care, Brunel University, West London, UB8 3PH, UK
    Ann N Y Acad Sci 1100:250-63. 2007

Detail Information

Publications5

  1. ncbi Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts
    Ishita S Mehta
    Centre for Cell and Chromosome Biology, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, UB8 3PH, UK
    Genome Biol 11:R5. 2010
    ..Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status. However, it is not yet clear when and how chromosome repositioning is elicited...
  2. ncbi Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells
    Ishita S Mehta
    Progeria Research Team, Centre for Cell and Chromosome Biology, Biosciences, School of Health Sciences and Social Care, Brunel University, West London, UB8 3PH, UK
    Genome Biol 12:R74. 2011
    ..Farnesyltransferase inhibitors prevent the accumulation of farnesylated progerin, producing a less toxic protein...
  3. ncbi Nuclear motors and nuclear structures containing A-type lamins and emerin: is there a functional link?
    Ishita S Mehta
    Division of Biosciences, Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, School of Health Sciences and Social Care, Brunel University, Uxbridge, UK
    Biochem Soc Trans 36:1384-8. 2008
    ..If any of the components are lacking or aberrant, then the nuclear motor complex involved in moving chromosomes or genes will be dysfunctional, leading to an inability to move chromosomes in response to signalling events...
  4. ncbi Progeria, the nucleolus and farnesyltransferase inhibitors
    Ishita S Mehta
    Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge UB8 3PH, UK
    Biochem Soc Trans 38:287-91. 2010
    ..This is encouraging news for the HGPS patients who are currently undergoing clinical trials with FTI treatment...
  5. ncbi Alterations to nuclear architecture and genome behavior in senescent cells
    Ishita S Mehta
    Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Biosciences, School of Health Sciences and Social Care, Brunel University, West London, UB8 3PH, UK
    Ann N Y Acad Sci 1100:250-63. 2007
    ....