Amanda J Harvey

Summary

Affiliation: Brunel University
Country: UK

Publications

  1. ncbi Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage
    Amanda J Harvey
    Brunel Institute for Cancer Genetics and Pharmacogenomics, Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, Middlesex, United Kingdom
    Am J Pathol 175:1226-34. 2009
  2. ncbi Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes
    J Tupper
    School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, UK
    Arch Dermatol Res 303:293-7. 2011
  3. ncbi RNA interference targeting of Bcr-Abl increases chronic myeloid leukemia cell killing by 17-allylamino-17-demethoxygeldanamycin
    Jane M E Withey
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    Leuk Res 30:553-60. 2006
  4. ncbi Targeting primary human leukaemia cells with RNA interference: Bcr-Abl targeting inhibits myeloid progenitor self-renewal in chronic myeloid leukaemia cells
    Jane M E Withey
    Department of Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK
    Br J Haematol 129:377-80. 2005
  5. ncbi Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation
    Amanda J Harvey
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 OEX, UK
    Oncogene 22:5006-10. 2003
  6. ncbi The Brk protein tyrosine kinase as a therapeutic target in cancer: opportunities and challenges
    Amanda J Harvey
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    Anticancer Drugs 15:107-11. 2004
  7. ncbi Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts
    Ishita S Mehta
    Centre for Cell and Chromosome Biology, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, UB8 3PH, UK
    Genome Biol 11:R5. 2010

Collaborators

Detail Information

Publications7

  1. ncbi Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage
    Amanda J Harvey
    Brunel Institute for Cancer Genetics and Pharmacogenomics, Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, Middlesex, United Kingdom
    Am J Pathol 175:1226-34. 2009
    ..Therefore, Brk enhances breast carcinoma cell survival in suspension, suggesting a role for Brk in supporting breast cancer cell dissemination...
  2. ncbi Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes
    J Tupper
    School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey, UK
    Arch Dermatol Res 303:293-7. 2011
    ..We propose Brk, Keratin 10 and EGFR are co-regulated during differentiation and that manipulating Brk expression can influence the differentiation of normal primary human keratinocytes...
  3. ncbi RNA interference targeting of Bcr-Abl increases chronic myeloid leukemia cell killing by 17-allylamino-17-demethoxygeldanamycin
    Jane M E Withey
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    Leuk Res 30:553-60. 2006
    ..Combination targeting strategies such as this may therefore achieve enhanced therapeutic potency...
  4. ncbi Targeting primary human leukaemia cells with RNA interference: Bcr-Abl targeting inhibits myeloid progenitor self-renewal in chronic myeloid leukaemia cells
    Jane M E Withey
    Department of Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, UK
    Br J Haematol 129:377-80. 2005
    ....
  5. ncbi Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation
    Amanda J Harvey
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 OEX, UK
    Oncogene 22:5006-10. 2003
    ..These data identify Brk as a novel target for antiproliferative therapy in the majority of breast cancers, and illustrate the power of RNA interference for rapidly validating candidate therapeutic targets...
  6. ncbi The Brk protein tyrosine kinase as a therapeutic target in cancer: opportunities and challenges
    Amanda J Harvey
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    Anticancer Drugs 15:107-11. 2004
    ..Further research into Brk's signaling functions will underpin progress towards turning the potential suggested by these observations into rational drug discovery, from which a large number of patients stand to benefit...
  7. ncbi Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts
    Ishita S Mehta
    Centre for Cell and Chromosome Biology, Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Kingston Lane, Uxbridge, UB8 3PH, UK
    Genome Biol 11:R5. 2010
    ..Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status. However, it is not yet clear when and how chromosome repositioning is elicited...