Rupert M Pearse

Summary

Affiliation: Barts and The London NHS Trust
Country: UK

Publications

  1. ncbi Peri-operative hemodynamic therapy: only large clinical trials can resolve our uncertainty
    Neil MacDonald
    Intensive care Research Office, Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, 4th Floor Holland Wing, Royal London Hospital, Whitechapel High Street, London E1 1BB, UK
    Crit Care 15:122. 2011
  2. ncbi Extending the role of lactate measurement into the prehospital environment
    Rupert M Pearse
    Intensive Care Unit, Royal London Hospital, Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, London, UK
    Crit Care 13:115. 2009
  3. ncbi Effect of dopexamine infusion on mortality following major surgery: individual patient data meta-regression analysis of published clinical trials
    Rupert M Pearse
    Royal London Hospital, Whitechapel, London, United Kingdom
    Crit Care Med 36:1323-9. 2008
  4. ncbi Steroids to prevent postextubation laryngeal oedema
    Rupert M Pearse
    Barts and the London School of Medicine and Dentistry, Royal London Hospital, London, E1 1BB, UK
    Lancet 369:1060-1. 2007
  5. ncbi The incidence of myocardial injury following post-operative Goal Directed Therapy
    Rupert M Pearse
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, UK
    BMC Cardiovasc Disord 7:10. 2007
  6. ncbi Should we use central venous saturation to guide management in high-risk surgical patients?
    Rupert M Pearse
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, St Bartholomew s Hospital, London EC1A 7BE, UK
    Crit Care 10:181. 2006
  7. ncbi Identification and characterisation of the high-risk surgical population in the United Kingdom
    Rupert M Pearse
    William Harvey Research Institute, Queen Mary s School of Medicine and Dentistry, London, UK
    Crit Care 10:R81. 2006
  8. ncbi Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial
    Shaman Jhanji
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, Turner Street, London E1 2AD, UK
    Crit Care 14:R151. 2010
  9. ncbi Using oxygen delivery targets to optimize resuscitation in critically ill patients
    Tarannum Rampal
    Queen Mary s University of London, UK
    Curr Opin Crit Care 16:244-9. 2010
  10. ncbi Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications
    Shaman Jhanji
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Intensive Care Med 35:671-7. 2009

Detail Information

Publications17

  1. ncbi Peri-operative hemodynamic therapy: only large clinical trials can resolve our uncertainty
    Neil MacDonald
    Intensive care Research Office, Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, 4th Floor Holland Wing, Royal London Hospital, Whitechapel High Street, London E1 1BB, UK
    Crit Care 15:122. 2011
    ..Such limitations may be impossible to completely eliminate from trials of complex interventions, but large multicenter trials may allow us to substantially decrease bias and improve the generalizability of the findings...
  2. ncbi Extending the role of lactate measurement into the prehospital environment
    Rupert M Pearse
    Intensive Care Unit, Royal London Hospital, Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, London, UK
    Crit Care 13:115. 2009
    ..Larger observational and interventional trials are needed to confirm the clinical value of serum lactate measurement in the prehospital environment...
  3. ncbi Effect of dopexamine infusion on mortality following major surgery: individual patient data meta-regression analysis of published clinical trials
    Rupert M Pearse
    Royal London Hospital, Whitechapel, London, United Kingdom
    Crit Care Med 36:1323-9. 2008
    ..To establish whether perioperative low-dose dopexamine infusion (< or = 1 microg/kg/min) is associated with a reduction in mortality and duration of hospital stay following major surgery...
  4. ncbi Steroids to prevent postextubation laryngeal oedema
    Rupert M Pearse
    Barts and the London School of Medicine and Dentistry, Royal London Hospital, London, E1 1BB, UK
    Lancet 369:1060-1. 2007
  5. ncbi The incidence of myocardial injury following post-operative Goal Directed Therapy
    Rupert M Pearse
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, UK
    BMC Cardiovasc Disord 7:10. 2007
    ..However, there is concern that pre-emptive use of inotropic therapy may lead to an increased incidence of myocardial ischaemia and infarction...
  6. ncbi Should we use central venous saturation to guide management in high-risk surgical patients?
    Rupert M Pearse
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, St Bartholomew s Hospital, London EC1A 7BE, UK
    Crit Care 10:181. 2006
    ..Our understanding of ScvO2 measurement remains limited, however, and the routine use of peri-operative ScvO2-guided goal-directed therapy cannot be recommended until a large randomised trial has confirmed the value of this approach...
  7. ncbi Identification and characterisation of the high-risk surgical population in the United Kingdom
    Rupert M Pearse
    William Harvey Research Institute, Queen Mary s School of Medicine and Dentistry, London, UK
    Crit Care 10:R81. 2006
    ..The aim of the present study was to estimate the size of the high-risk general surgical population and to describe the outcome and intensive care unit (ICU) resource use...
  8. ncbi Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial
    Shaman Jhanji
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, Turner Street, London E1 2AD, UK
    Crit Care 14:R151. 2010
    ....
  9. ncbi Using oxygen delivery targets to optimize resuscitation in critically ill patients
    Tarannum Rampal
    Queen Mary s University of London, UK
    Curr Opin Crit Care 16:244-9. 2010
    ..The aim of this review is to describe the current evidence base for this treatment and how concepts of haemodynamic optimization have evolved in recent years...
  10. ncbi Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications
    Shaman Jhanji
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Intensive Care Med 35:671-7. 2009
    ..To evaluate the relationship between global oxygen delivery (DO(2)I), microvascular flow and tissue oxygenation in patients who did and did not develop complications following major abdominal surgery...
  11. ncbi Comparison of three methods of extravascular lung water volume measurement in patients after cardiac surgery
    Benjamin Maddison
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, Royal London Hospital, London E1 1BB, UK
    Crit Care 13:R107. 2009
    ..Measurement of extravascular lung water (EVLW) by using the lithium-thermal (Li-thermal) and single-thermal indicator dilution methods was compared with the indocyanine green-thermal (ICG-thermal) method in humans...
  12. ncbi The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock
    Shaman Jhanji
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, London, United Kingdom
    Crit Care Med 37:1961-6. 2009
    ..To investigate the effect of escalating doses of norepinephrine, aimed at achieving incremental increases in mean arterial pressure (MAP), on microvascular flow and tissue oxygenation in patients with septic shock...
  13. ncbi Early microvascular changes in sepsis and severe sepsis
    Angeliki Spanos
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, London, United Kingdom
    Shock 33:387-91. 2010
    ..These abnormalities are more marked in the most severely ill patients. Further research is required to fully characterize the effects of sepsis on microvascular function...
  14. ncbi Clinical review: how to optimize management of high-risk surgical patients
    Rupert M Pearse
    St George s Hospital, London, UK
    Crit Care 8:503-7. 2004
    ..In this review a pragmatic approach to perioperative management is described, giving guidance on the identification of the high-risk patient and on the use of goal-directed haemodynamic therapy and beta blockade...
  15. ncbi Role of central and mixed venous oxygen saturation measurement in perioperative care
    Stephen J Shepherd
    Barts and The London NHS Trust, London, United Kingdom
    Anesthesiology 111:649-56. 2009
    ..The purpose of this article is to describe the physiology and measurement of mixed and central venous oxygen saturation and to explore the findings of clinical investigations of their use in perioperative care...
  16. ncbi Extravascular lung water volume measurement by a novel lithium-thermal indicator dilution method: comparison of three techniques to post-mortem gravimetry
    Benjamin Maddison
    Intensive Care Unit, Royal London Hospital, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Intensive Care Med 34:2106-11. 2008
    ....
  17. ncbi The use of early intervention to prevent postoperative complications
    Shaman Jhanji
    Barts and the London School of Medicine and Dentistry, Queen Mary s University of London, London, UK
    Curr Opin Crit Care 15:349-54. 2009
    ..Patients who develop complications suffer a reduction in long-term survival. This review aims to explore recent advances in the management of surgical patients aimed at preventing postoperative complications...