M Emre

..The purpose of this article is to provide an overview of recent findings on dementia associated with Parkinson's disease, from February 2003 to the present...

..In both populations, hallucinations may identify patients who are likely to be more treatment-responsive...

..The evidence for efficacy, however, is not strong for the majority of these compounds...

..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...

..Therefore, the efficacy and safety of memantine were investigated in patients with mild to moderate Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB)...

..Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor rivastigmine in such patients...

..Based on a large, randomized, placebo controlled trial, the ChE-I rivastigmine has been approved for the treatment of dementia associated with PD...

..It is concluded that treatment with memantine provides benefits in all three cognitive functions...

..This article is an attempt to provide a comprehensive, yet simplified classification of dementias following a mechanism-based approach. A systematic approach to diagnostic work-up is also proposed based on this classification...

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..Alzheimer's disease-type pathology is commonly associated with dementia but less predictive. Recent evidence from small studies suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD...

..Rivastigmine patch provides an efficient option for managing patients with AD, to be considered among the first line therapies for the disease...

..Likewise, recent studies suggest that some statins may have a prophylactic effect...

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..0% (95% CI, 7.0% to 15.0%) and 20.0% (95% CI, 14.0% to 26.0%), respectively, in this population. Prevalence rates of dementia and AD in Istanbul, Turkey, are comparable with those seen in the Western world...

..We conclude that hemiballism following unilateral ablation of STN in patients with PD is a rare phenomenon, and unilateral ablative lesions of STN can be performed safely...

..Recent evidence from small double-blind and open-label trials suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD...

..She improved substantially with clonazepam 4 mg/day. She presented with electrophysiological findings not previously reported in stiff leg syndrome, which may suggest increased inhibition in the uninvolved upper extremities...

..In addition, the 194Trp allele revealed a borderline significance (OR=2.05, 95% CI 0.96-4.37, p=0.056). According to our results, it may be speculated that the polymorphic variants of XRCC1 codon 194 have a role in the development of AD...

..We suggest that celiac disease can present with a variety of unusual neurological manifestations...

..These results indicate subclinical impairment of cognitive functions in patients with ALS. The pattern of cognitive impairment suggests the dysfunction of the frontal network...

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..Further investigation of parkin expression in skeletal muscle is warranted...

..To assess the attitude of elderly lay people towards the concept and symptoms of dementia...

..006) indicating a protective role of the "AT" haplotype in AD. Consequently, this study provides evidence for a possible link between AD and vitamin D...

..We suggest that clozapine should be considered in patients with OMD who fail to response to other treatments...

..This finding may be due to cytotoxic edema associated with status epilepticus and may mimic herpes simplex and other limbic encephalitides. Though not typical, certain MRI findings guides for the diagnosis of neurosyphilis...

..52, P = .32, respectively), when the control and patients were compared. Consequently, our results showed that the 1/1 genotype does not increase the risk of developing late-onset Alzheimer's disease in the Turkish population...

..77, 95% CI = 1.12-6.85). Our results suggest that having a higher education is protective from AD and that electromagnetic field exposure at work or at home is a significant risk factor...

..The aim of the current study is to determine whether there is an association between the promoter region polymorphism of the interleukin-1alpha gene and late-onset AD in a cohort of Turkish patients...

..In this study, the data indicate no significant differences in mitochondrial complex I-IV activities in PDF and PDS...

..08, 95% CI=0.70-1.68), XRCC1-Arg280His (OR=0.53, 95% CI=0.24-1.14) and XRCC1-Arg399Gln (OR=1.05, 95% CI=0.68-1.63) and AD. Our results suggest that the polymorphic variants of these BER genes are not independent risk factors for AD...

..Most studies of old age depression have been conducted in developed countries. The present study was conducted to determine the prevalence of depressive disorders among Turkish elderly in an urban community...

..94, 95% CI=0.63-1.41), XPD/exon 23 (OR=1.24, 95% CI=0.82-1.86) and XPF/exon 11 (OR=1.08, 95% CI=0.72-1.64) and AD. Our results suggest that the polymorphic variants of these NER genes do not contribute to the risk of developing AD...

..The latency prolongation observed with the NoGo condition of the CPT paradigm was thought to be due to perseverance/inhibition conflict enhanced by the primer stimuli in CPT...

..Long-term rivastigmine treatment appeared well tolerated and may provide sustained benefits in dementia associated with PD patients who remain on treatment for up to 48 weeks...

..Visual hallucinations appear to predict more rapid decline and possibly greater therapeutic benefit from rivastigmine treatment in PDD...

..The panel also aimed to reach consensus on 'whom to switch', 'when to switch' and 'how to switch'. The key findings from that meeting are reported in this review...

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..To compare the profile of cognitive impairment in Alzheimer's disease (AD) with dementia associated with Parkinson's disease (PDD)...

..We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies...

..The current analyses were performed to examine the potential of rivastigmine to affect tremor and other motor symptoms in patients with PDD...

..These findings raise the question whether PIGD and dementia share common or parallel neuropathology...

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